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7.6.2.9: ABC-type quaternary amine transporter

This is an abbreviated version!
For detailed information about ABC-type quaternary amine transporter, go to the full flat file.

Word Map on EC 7.6.2.9

Reaction

ATP
+
H2O
 +
quaternary amine-[quaternary amine-binding protein][side 1]
=
ADP
 +
phosphate
 +
quaternary amine[side 2]
 +
[quaternary amine-binding protein][side 1]

Synonyms

ABC transporter, BetTA.halophytica, EC 3.6.3.32, glycine betaine porter II, glycine betaine transport system permease protein, glycine betaine transporter membrane protein, glycine betaine-binding protein, glycine betaine-binding protein OpuAC, glycine betaine/carnitine/choline-binding protein, glycine/betaine ABC transporter, N288_21505, N288_21525, N288_25665, OpuA, OpuAB, OpuAC, OpuB, OpuBC, OpuC, OpuCC, OpuD, OpuF, OpuF transporter, proline/betaine ABC transporter permease, ProU, proW, Quaternary-amine-transporting ATPase

ECTree

     7 Translocases
         7.6 Catalysing the translocation of other compounds
             7.6.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.6.2.9 ABC-type quaternary amine transporter

Activating Compound

Activating Compound on EC 7.6.2.9 - ABC-type quaternary amine transporter

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
anionic lipids
-
absence of phosphatidylglycerol and/or phosphatidylserine results in trapping of the protein in an inactive state
-
dioleoyl-phosphatidylglycerol
needed for full osmoregulatory activity
glycerol
-
at 270 mM, the amount of glycine betaine taken up after 30 seconds is 30% higher than that of the iso-osmotic control sample
negatively charged lipid
-
-
-
phosphate ion-containing buffer
-
-
-
phosphatidylethanolamine
-
non-bilayer lipid essential for high activity of OpuA
Tetracaine
instantaneously activates inside-out oriented OpuA, reconstitued in membranes with 40% of anionic lipid, 1mM equally effective than 0.2 mM KCl
additional information
-