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7.6.2.1: P-type phospholipid transporter

This is an abbreviated version!
For detailed information about P-type phospholipid transporter, go to the full flat file.

Word Map on EC 7.6.2.1

Reaction

ATP
+
H2O
 +
phospholipid [side 1]
=
ADP
 +
phosphate
 +
phospholipid [side 2]

Synonyms

ABCB1, ABCB4, ALA1, ALA10, ALA11, ALA12, ALA2, ALA3, ALA4, ALA5, ALA7, ALA8, ALA9, aminophospholipid ATPase, aminophospholipid flippase, aminophospholipid flippase 10, aminophospholipid flippase 11, aminophospholipid flippase 12, aminophospholipid scramblase, aminophospholipid translocase, aminophospholipid translocase VC, aminophospholipid transporter, aminophospholipid-translocase, aminophosphoplipid translocase, APLT, ATP phosphohydrolase (phospholipid-flipping), ATP-dependent specific phospholipid flippase, ATP-independent flippase, ATP-independent long-chain phosphatidylcholine translocator, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B, ATP11C, ATP8A1, Atp8a2, ATP8B1, ATP8B2, ATP8B3, ATP8B4, ATP8B5, ATP9A, ATP9B, ATPase II, ATPVC, ATPVD, CDC50A, Cdc50p-Drs2p, Cfs1p, Dnf1, Dnf1 |, Dnf1p, Dnf1p and Dnf2p, Dnf1p-Lem3p, Dnf2, Dnf2p, Dnf3, Dnf3p, Drs2, Drs2-dependent phosphatidylserine translocase, Drs2p, EC 3.6.3.1, EC 3.6.3.13, energy-dependent lipid flippase, energy-independent lipid flippase, EpsE, erythroid ATP-dependent aminophospholipid transporter, flippase, glycerophospholipid flippase, HUSSY-20, inward-directed phospholipid translocase, LdMT, LdRos3, lipid flippase, LMT translocase, M5-DLO flippase, Man5GlcNAc2-PP-dolichol flippase, MDR3 P-glycoprotein, Mg2+-ATPase, Mg2+-ATPase A, miltefosine transporter, More, MsbA, multidrug resistance 3 P-glycoprotein, MurJ, MviN, Neo1, Neo1p, P type aminophospholipid transporter, P-glycoprotein, P-gp, P4 ATPase ALA1, P4-ATPase, P4-type ATPase, PC-flippase, peptidoglycan lipid II flippase, phosphatidylserine flippase, phosphatidylserine translocase, phosphatidylserine translocase/ATPase, phospholipid flippase, phospholipid scramblase, phospholipid scramblase 1, phospholipid scramblase 3, phospholipid scrambling activity, phospholipid translocase, phospholipid-translocase, phospholipid-translocating ATPase, phospholipid-transporting ATPase IB, PL flippase, PL scramblase, PLS3, PLSCR1, PLSCR2, PLSCR3, PLSCR4, PS flippase, PS translocase, PS-flippase, scramblase, SCRM-1, sphingomyelin flippase, TAT-1, TAT-2, TAT-3, TAT-4, TAT-5, TAT-6, transbilayer amphipath transporter, transbilayer amphipath transporter-1, type 4 P-type ATPas, type II secretion ATPase, type IV P-type ATPase

ECTree

     7 Translocases
         7.6 Catalysing the translocation of other compounds
             7.6.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.6.2.1 P-type phospholipid transporter

Purification

Purification on EC 7.6.2.1 - P-type phospholipid transporter

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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ATP8A1 from chromaffin granules
-
concanavalin A-Sepharose 4B affinity column chromatography and Sephadex G50 gel filtration
-
membrane vesicle preparation from strain 1E51, purification by Triton X-100 extraction, glycerol fradient fractionation, and ion exchange chromatography, and reconstitution of the active enzyme in proteoliposomes, overview
-
native Atp8a2 1887fold from photoreceptor outer segments by immunoaffinity chromatography
native enzyme from chromaffin granules
-
native enzyme from liver endoplasmic reticulum
-
native enzymes partially by subcellular fractionation
-
Ni-NTA column chromatography
partial
-
partially by microsome preparation
-
partially from erythrocytes
-
recombinant enzyme from HEK-293 cells by immunoaffinity chromatography
recombinant His-tagged Atp8a1 from Spodoptera frugiperda Sf21 cells by microsome preparation and nickel affinity chromatography
-
recombinant wild-type and mutant enzymes
-
Sepharose bead column chromatography
-