7.2.4.3: (S)-methylmalonyl-CoA decarboxylase (sodium-transporting)

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For detailed information about (S)-methylmalonyl-CoA decarboxylase (sodium-transporting), go to the full flat file.

Reaction

Synonyms

Decarboxylase, methylmalonyl coenzyme A, EC 4.1.1.41, Methylmalonyl-CoA decarboxylase, Methylmalonyl-coenzyme A decarboxylase, MMCD, Propionyl coenzyme A carboxylase, Propionyl-CoA carboxylase, Sodium pump methylmalonyl-CoA decarboxylase

ECTree

     7 Translocases

         7.2 Catalysing the translocation of inorganic cations

             7.2.4 Linked to decarboxylation

                7.2.4.3 (S)-methylmalonyl-CoA decarboxylase (sodium-transporting)

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Results	in table
410	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
2	Expression
5	General Information
10	Inhibitors
6	KM Value [mM]
4	Localization
4	Metals/Ions
17	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
12	Organism
1	Pathway
3	pH Optimum
4	Purification (Commentary)
1	Reaction
1	Reaction Type
12	Reference
3	Specific Activity [micromol/min/mg]
22	Substrates and Products (Substrate)
6	Subunits
9	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 7.2.4.3 - (S)-methylmalonyl-CoA decarboxylase (sodium-transporting)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2]

propanoyl-CoA + CO2 + Na+[side 2]

8 entries

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2]

propanoyl-CoA + CO2 + Na+[side 2]

Propionigenium modestum

-

the enzyme catalyzes the only energy-conserving step during succinate fermentation. The decarboxylation of (S)-methylmalonyl-CoA is coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis

4553

-

-

?

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2]

propanoyl-CoA + CO2 + Na+[side 2]

Veillonella parvula

-

enzyme of the succinate pathway

4549

-

-

?

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2]

propanoyl-CoA + CO2 + Na+[side 2]

Veillonella parvula

-

the Na+-transport enzyme converts the chemical energy of a decarboxylation reaction into an ion gradient

4550

-

-

?

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2]

propanoyl-CoA + CO2 + Na+[side 2]

Veillonella parvula

-

the enzyme is responsible for the formation of the propionate moiety in the fermentation of lactate and the decarboxylation of succinate

4548

-

-

?

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2]

propanoyl-CoA + CO2 + Na+[side 2]

Veillonella parvula

-

the enzyme is one of the sodium pumps, which are driven by decarboxylation energy

4545

-

-

?

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2]

propanoyl-CoA + CO2 + Na+[side 2]

Veillonella parvula

-

reconstitution of the sodium pump

4545, 4546

-

-

?

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2]

propanoyl-CoA + CO2 + Na+[side 2]

Veillonella parvula

-

the enzyme is a sodium-transport decarboxylase

4547

-

-

?

(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2]

propanoyl-CoA + CO2 + Na+[side 2]

Veillonella parvula

-

proteoliposomes are reconstituted with the Na+-pump methylmalonyl-CoA decarboxylase from Veillonella alcalescens

4550

-

-

?