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highest expression levels of PCCalpha in adult central nervous system in neocortex and hippocampal formation, thalamic and hypothalamic nuclei, midbrain nuclei such as the red nucleus and substantia nigra, as well as pons, medulla and the Purkinje and granular layers of cerebellum. PCCalpha is expressed in neurons of basal ganglia. High expression levels of PCCalpha in the whole embryonic central nervous system, both at E15.5 and E18.5, with the highest expression in the periventricular zones of telencephalon, midbrain and rhombencephalon. Choroid plexus also expresses high levels. Expression in embryonic liver increases towards E18.5. Outside the central nervous system, brown adipose tissue shows a very high expression level