6.5.1.2: DNA ligase (NAD+)

This is an abbreviated version!
For detailed information about DNA ligase (NAD+), go to the full flat file.

Reaction

Synonyms

beta-NAD+ -dependent DNA ligase, beta-NAD+-dependent DNA ligase, Deoxyribonucleate ligase, Deoxyribonucleic acid joinase, Deoxyribonucleic acid ligase, Deoxyribonucleic joinase, Deoxyribonucleic ligase, Deoxyribonucleic repair enzyme, Deoxyribonucleic-joining enzyme, DNA joinase, DNA ligase, DNA ligase (NAD), DNA repair enzyme, DNA-joining enzyme, LigA, Ligase, polynucleotide (nicotinamide adenine dinucleotide), LigN, MimiLIG, MsEPV DNA ligase, MtuLigA, NAD(+)-dependent DNA ligase, NAD+ dependent DNA ligase, NAD+ DNA ligase, NAD+-dependent DNA ligase, NAD+-dependent DNA ligase A, NAD-dependent DNA ligase, NDL, Polydeoxyribonucleotide synthase (NAD+), Polydeoxyribonucleotide synthase [NAD+], Polynucleotide ligase, Polynucleotide synthetase, Polynucleotide synthetase (nicotinamide adenine dinucleotide), Rv3014c, Synthetase, polydeoxyribonucleotide (nicotinamide adenine dinucleotide), T4 DNA ligase, Taq DNA ligase, Tfi DNA ligase, Tth DNA ligase, wBm-LigA

ECTree

     6 Ligases

         6.5 Forming phosphoric-ester bonds

             6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

                6.5.1.2 DNA ligase (NAD+)

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Results	in table
16	Activating Compound
48846	AA Sequence
22	Application
1	CAS Registry Number
51	Cloned(Commentary)
120	Cofactor
13	Crystallization (Commentary)
1	Expression
3	General Information
1	General Stability
449	IC50 Value
614	Inhibitors
7	Ki Value [mM]
38	KM Value [mM]
85	Metals/Ions
27	Molecular Weight [Da]
112	Natural Substrates/ Products (Substrates)
877	Organism
56	PDB ID
20	pH Optimum
8	pH Range
1	pH Stability
183	Protein Variants
51	Purification (Commentary)
32	Reaction
1	Reaction Type
193	Reference
5	Specific Activity [micromol/min/mg]
5	Storage Stability
245	Substrates and Products (Substrate)
13	Subunits
249	Synonyms
1	Systematic Name
24	Temperature Optimum [°C]
10	Temperature Range [°C]
16	Temperature Stability [°C]
15	Turnover Number [1/s]

KI Value

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KI Value on EC 6.5.1.2 - DNA ligase (NAD+)

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0977

1-(4-aminopiperidin-1-yl)-6-(6,7-dihydro-12H-benzo[2,3]oxepino[4,5-b]indol-12-yl)-hexane-2-ol

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

748806

0.0942

1-(4-aminopiperidin-1-yl)-6-(dibenzo[b,e][1,4]oxazepin-5(11H)-yl)hexan-2-ol

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

748806

0.0014

2,4-diamino-7-dimethylamino-pyrimido[4,5-d]pyrimidine

Streptococcus pneumoniae

-

-

692315

0.000032

AMP

Haemophilus influenzae

-

pH and temperature not specified in the publication

747433

0.000051 - 0.000065

deoxyribonucleotide

2 entries

-

0.000066

nicotinamide mononucleotide

Haemophilus influenzae

-

pH and temperature not specified in the publication

747433

0.000051

deoxyribonucleotide

Streptococcus pneumoniae

-

wild-type, 25°C, pH 7.5

726920

-

0.000065

deoxyribonucleotide

Streptococcus pneumoniae

-

co-substrate: NAD+, mutant L75F, 25°C, pH 7.5

726920

-