6.4.1.3: propionyl-CoA carboxylase
This is an abbreviated version!
For detailed information about propionyl-CoA carboxylase, go to the full flat file.
Word Map on EC 6.4.1.3
-
6.4.1.3
-
propionic
-
acidemia
-
biotin-dependent
-
carboxylases
-
methylmalonyl-coa
-
acidosis
-
methylmalonic
-
3-hydroxypropionate
-
methylcitrate
-
propionylation
-
hyperammonemia
-
holocarboxylase
-
3-methylcrotonyl-coa
-
acidurias
-
biotin-containing
-
carboxyltransferase
-
biotin-deficient
-
hyperglycinemia
-
beta-methylcrotonyl-coa
-
biotin-binding
-
odd-chain
-
anaplerosis
-
transcarboxylase
-
3-hydroxyisovaleric
-
propionylcarnitine
-
synthesis
-
analysis
-
medicine
-
apocarboxylases
-
biotinidase
- 6.4.1.3
- propionic
- acidemia
-
biotin-dependent
- carboxylases
- methylmalonyl-coa
- acidosis
-
methylmalonic
- 3-hydroxypropionate
-
methylcitrate
-
propionylation
-
hyperammonemia
- holocarboxylase
- 3-methylcrotonyl-coa
- acidurias
-
biotin-containing
- carboxyltransferase
-
biotin-deficient
- hyperglycinemia
- beta-methylcrotonyl-coa
-
biotin-binding
-
odd-chain
-
anaplerosis
- transcarboxylase
-
3-hydroxyisovaleric
- propionylcarnitine
- synthesis
- analysis
- medicine
- apocarboxylases
- biotinidase
Reaction
Synonyms
AccA3-PccB complex, acetyl-CoA/propionyl-CoA carboxylase, Carboxylase, propional coenzyme A (adenosine triphosphate-hydrolyzing), LA_2736-LA_2735, Pcase, PCC, PccA, PccA-1, PCCase, PccB, PccB-1, pccBC, PccE, Propanoyl-CoA:carbon dioxide ligase, Propionyl coenzyme A carboxylase, Propionyl coenzyme A carboxylase (adenosine triphosphate-hydrolyzing), Propionyl coenzyme A carboxylase (ATP-hydrolyzing), Propionyl-CoA carboxylase, propionyl-coenzyme A carboxylase
ECTree
6.4.1.3 propionyl-CoA carboxylaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 6.4.1.3 - propionyl-CoA carboxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + acetyl-CoA + HCO3-
?
Q877I4; Q877I3; Q877I5
n-butyryl-CoA (0.5 mM) is carboxylated at 4.6% compared to carboxylation of acetyl-CoA or propionyl-CoA
-
-
?
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + ?
-
at 3% the velocity compared to propanoyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
?
-
key enzyme of the 3-hydroxypropanoate cycle
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (2S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
preferred substrate
-
-
?
acetyl-CoA + CO2
?
the enzyme has a preference for propionyl-CoA over acetyl-CoA as the substrate
-
-
?
acetyl-CoA + CO2
?
the wild type enzyme shows no activity with acetyl-CoA, but mutant enzyme D422I does
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
at a rate 1.5% that obtained for propionyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no other acetyl-CoA carboxylase detected in this organism
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
the enzyme has a preference for propanoyl-CoA over acetyl-CoA as the substrate
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
at 0.7% of the velocity compared to propanoyl-CoA
-
-
?
ATP + butanoyl-CoA + HCO3-
ADP + phosphate + ?
-
at 5.7% of the velocity compared to propanoyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Q877I4; Q877I3; Q877I5
the bifunctional enzyme also catalyzes the carboxylation of acetyl-CoA. Vmax/Km for carboxylation of propanoyl-CoA is 1.6fold higher than Vmax/Km for carboxylation of acetyl-CoA. Quite specific for ATP. No activity with ADP, AMP, GTP, CTP, UTP, or dTTP (0.2 mM)
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Acidianus infernus So4a / DSM 3191
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Acidianus infernus So4a / DSM 3191
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for long-chain fatty acids, polyketides and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
the enzyme has a preference for propanoyl-CoA over acetyl-CoA as the substrate
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
important for polyketide and fatty acid synthesis
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
GTP + propanoyl-CoA + HCO3-
GDP + phosphate + (S)-methylmalonyl-CoA
-
10% of the activity with ATP
-
?
GTP + propanoyl-CoA + HCO3-
GDP + phosphate + (S)-methylmalonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
10% of the activity with ATP
-
?
propionyl-CoA + CO2
(S)-methylmalonyl-CoA
the enzyme has a preference for propionyl-CoA over acetyl-CoA as the substrate
-
-
?
UTP + propanoyl-CoA + HCO3-
UDP + phosphate + (S)-methylmalonyl-CoA
-
40% of the activity with ATP
-
?
UTP + propanoyl-CoA + HCO3-
UDP + phosphate + (S)-methylmalonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
40% of the activity with ATP
-
?
additional information
?
-
Q877I4; Q877I3; Q877I5
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
enzyme may play an important role in the biosynthesis of rifamycin as well as in the degradation of various amino acids
-
-
?
additional information
?
-
-
inherited deficiency of the enzyme activity leads to propionicacidemia
-
-
?
additional information
?
-
-
inherited deficiency of the enzyme activity leads to propionicacidemia
-
-
?
additional information
?
-
-
methylmalonyl-CoA, malonyl-CoA, isobutyryl-CoA, and isovaleryl-CoA are not metabolized
-
?
additional information
?
-
-
required for development of Myxococcus xanthus. The dcm-1 mutant, which is deficient in propanoyl-CoA carboxylase is unable to form fruiting bodies and spores
-
-
?
additional information
?
-
the wild type enzyme shows no activity with acetyl-CoA
-
-
?
additional information
?
-
-
the wild type enzyme shows no activity with acetyl-CoA
-
-
?
additional information
?
-
-
acetyl-CoA is not well converted to malonyl-CoA
-
-
?
