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6.4.1.3: propionyl-CoA carboxylase

This is an abbreviated version!
For detailed information about propionyl-CoA carboxylase, go to the full flat file.

Word Map on EC 6.4.1.3

Reaction

ATP
+
propanoyl-CoA
+
HCO3-
+
H+
=
ADP
+
phosphate
+
(S)-methylmalonyl-CoA

Synonyms

AccA3-PccB complex, acetyl-CoA/propionyl-CoA carboxylase, Carboxylase, propional coenzyme A (adenosine triphosphate-hydrolyzing), LA_2736-LA_2735, Pcase, PCC, PccA, PccA-1, PCCase, PccB, PccB-1, pccBC, PccE, Propanoyl-CoA:carbon dioxide ligase, Propionyl coenzyme A carboxylase, Propionyl coenzyme A carboxylase (adenosine triphosphate-hydrolyzing), Propionyl coenzyme A carboxylase (ATP-hydrolyzing), Propionyl-CoA carboxylase, propionyl-coenzyme A carboxylase

ECTree

     6 Ligases
         6.4 Forming carbon-carbon bonds
             6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
                6.4.1.3 propionyl-CoA carboxylase

Reference

Reference on EC 6.4.1.3 - propionyl-CoA carboxylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lamhonwah, A.M.; Quan, F.; Gravel, R.A.
Sequence homology around the biotin-binding site of human propionyl-CoA carboxylase and pyruvate carboxylase
Arch. Biochem. Biophys.
254
631-636
1987
Homo sapiens
Manually annotated by BRENDA team
Gygax, D.; Stalder, R.; Nuesch, J.
Propionyl-CoA carboxylase in Nocardia mediterranei
FEMS Microbiol. Lett.
23
211-216
1984
Amycolatopsis mediterranei
-
Manually annotated by BRENDA team
Haase, F.C.; Beegen, H.; Allen, S.H.G.
Propionyl-coenzyme A carboxylase of Mycobacterium smegmatis
Eur. J. Biochem.
140
147-151
1984
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Haase, F.C.; Henrikson, K.P.; Treble, D.H.; Allen, S.H.G.
The subunit structure and function of the propionyl coenzyme A carboxylase of Mycobacterium smegmatis
J. Biol. Chem.
257
11994-11999
1982
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Gravel, R.A.; Lam, F.K.; Mahuran, D.; Kronis, A.
Purification of human liver propionyl-CoA carboxylase by carbon tetrachloride extraction and monomeric avidin affinity chromatography
Arch. Biochem. Biophys.
201
669-673
1980
Homo sapiens
Manually annotated by BRENDA team
Kalousek, F.; Darigo, M.D.; Rosenberg, L.E.
Isolation and characterization of propionyl-CoA carboxylase from normal human liver. Evidence for a protomeric tetramer of nonidentical subunits
J. Biol. Chem.
255
60-65
1980
Homo sapiens
Manually annotated by BRENDA team
Henrikson, K.P.; Allen, S.H.G.
Purification and subunit structure of propionyl coenzyme A carboxylase of Mycobacterium smegmatis
J. Biol. Chem.
254
5888-5891
1979
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Lau, E.P.; Cochran, B.C.; Munson, L.; Fall, R.R.
Bovine kidney 3-methylcrotonyl-CoA and propionyl-CoA carboxylase: each enzyme contains nonidentical subunits
Proc. Natl. Acad. Sci. USA
76
214-218
1979
Bos taurus, Sus scrofa
Manually annotated by BRENDA team
Hector, M.L.; fall, R.R.
Multiple acyl-coenzyme A carboxylases in Pseudomonas citronellolis
Biochemistry
15
3465-3472
1976
Pseudomonas citronellolis
Manually annotated by BRENDA team
Erfle, J.D.
Acetyl-CoA and propionyl-CoA carboxylation by Mycobacterium phlei. Partial purification and some properties of the enzyme
Biochim. Biophys. Acta
316
143-155
1973
Mycolicibacterium phlei
Manually annotated by BRENDA team
Kaziro, Y.; Ochoa, S.; Warner, R.C.; Chen, J.Y.
Metabolism of propionic acid in animal tissues. VIII. Crystalline propionyl carboxylase
J. Biol. Chem.
236
1917-1923
1961
Sus scrofa
Manually annotated by BRENDA team
Kimura, Y.; Sato, R.; Mimura, K.; Sato, M.
Propionyl coenzyme A carboxylase is required for development of Myxococcus xanthus
J. Bacteriol.
179
7098-7102
1997
Myxococcus xanthus
Manually annotated by BRENDA team
Wurtele, E.S.; Nikolau, B.J.
Plants contain multiple biotin enzymes: discovery of 3-methylcrotonyl-CoA carboxylase, propionyl-CoA carboxylase and pyruvate carboxylase in the plant kingdom
Arch. Biochem. Biophys.
278
179-186
1990
Brassica napus, Daucus carota, Zea mays
Manually annotated by BRENDA team
Lamhonwah, A.M.; Mahuran, D.; Gravel, R.A.
Human mitochondrial propionyl-CoA carboxylase: localization of the N-terminus of the pro-and mature alpha chains in the deduced primary sequence of a full-length cDNA
Nucleic Acids Res.
17
4396
1989
Homo sapiens
Manually annotated by BRENDA team
Bramwell, H.; Hunter, I.S.; Coggins, J.R.; Nimmo, H.G.
Propionyl-CoA carboxylase from Streptomyces coelicolor A3(2): cloning of the gene encoding the biotin-containing subunit
Microbiology
142
649-655
1996
Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Manually annotated by BRENDA team
Garrastazu, C.; Iniesta, M.P.; Aranguez, M.I.; Amil, M.R.
Comparative analysis of propionyl-CoA carboxylase from liver and mammary gland of mid-lactation cow
Comp. Biochem. Physiol. B
99
613-617
1991
Bos taurus
Manually annotated by BRENDA team
Ishii, M.; Miyake, T.; Satoh, T.; Sugiyama, H.; Oshima, Y.; Kodama, T.; Igarashi, Y.
Autotrophic carbon dioxide fixation in Acidianus brierleyi
Arch. Microbiol.
166
368-371
1997
Acidianus brierleyi
Manually annotated by BRENDA team
Stankovic, J.; Ledley, F.D.
Cloning of functional alpha propionyl CoA carboxylase and correction of enzyme deficiency in pccA fibroblasts
Am. J. Hum. Genet.
52
144-151
1993
Homo sapiens
Manually annotated by BRENDA team
Kelson, T.L.; Ohura, T.; Kraus, J.P.
Chaperonin-mediated assembly of wild-type and mutant subunits of human propionyl-CoA carboxylase expressed in Escherichia coli
Hum. Mol. Genet.
5
331-337
1996
Homo sapiens
Manually annotated by BRENDA team
Kimura, Y.; Kojyo, T.; Kimura, I.; Sato, M.
Propionyl-CoA carboxylase of Myxococcus xanthus: catalytic properties and function in developing cells
Arch. Microbiol.
170
179-184
1998
Myxococcus xanthus
Manually annotated by BRENDA team
Hugler, M.; Krieger, R.S.; Jahn, M.; Fuchs, G.
Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation
Eur. J. Biochem.
270
736-744
2003
Chloroflexus aurantiacus, Metallosphaera sedula, Sulfuracidifex metallicus, Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348, Chloroflexus aurantiacus OK-70-fl / DSM 636
Manually annotated by BRENDA team
Schrick, J.J.; Lingrel, J.B.
cDNA cloning, mapping and expression of the mouse propionyl CoA carboxylase beta (pccb), the gene for human type II propionic acidaemia
Gene
264
147-152
2001
Homo sapiens, Mus musculus (Q99MN9)
Manually annotated by BRENDA team
Chloupkova, M.; Maclean, K.N.; Alkhateeb, A.; Kraus, J.P.
Propionic acidemia: analysis of mutant propionyl-CoA carboxylase enzymes expressed in Escherichia coli
Hum. Mutat.
19
629-640
2002
Homo sapiens, Homo sapiens (P05166)
Manually annotated by BRENDA team
Menendez, C.; Bauer, Z.; Huber, H.; Gad'on, N.; Stetter, K.O.; Fuchs, G.
Presence of acetyl coenzyme A (CoA) carboxylase and propionyl-CoA carboxylase in autotrophic Crenarchaeota and indication for operation of a 3-hydroxypropionate cycle in autotrophic carbon fixation
J. Bacteriol.
181
1088-1098
1999
Acidianus infernus, Acidianus infernus So4a / DSM 3191, Chloroflexus aurantiacus, Chloroflexus aurantiacus OK-70-fl / DSM 636, Metallosphaera sedula, Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348, Sulfuracidifex metallicus, Sulfuracidifex metallicus Kra23 / DSM 6482
Manually annotated by BRENDA team
Muro, S.; Perez, B.; Rodriguez-Pombo, P.; Desviat, L.R.; Perez-Cerda, C.; Ugarte, M.
Mutations affecting the beta-beta homomeric interaction in propionic acidaemia: An approach to the determination of the beta-propionyl-CoA carboxylase functional domains
J. Inherit. Metab. Dis.
23
300-304
2000
Homo sapiens
Manually annotated by BRENDA team
Rodriguez, E.; Gramajo, H.
Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2)
Microbiology
145
3109-3119
1999
Streptomyces coelicolor
-
Manually annotated by BRENDA team
Rodriguez-Melendez, R.; Perez-Andrade, M.E.; Diaz, A.; Deolarte, A.; Camacho-Arroyo, I.; Ciceron, I.; Ibarra, I.; Velazquez, A.
Differential effects of biotin deficiency and replenishment on rat liver pyruvate and propionyl-CoA carboxylases and on their mRNAs
Mol. Genet. Metab.
66
16-23
1999
Rattus norvegicus
Manually annotated by BRENDA team
Chloupkova, M.; Ravn, K.; Schwartz, M.; Kraus, J.P.
Changes in the carboxyl terminus of the beta subunit of human propionyl-CoA carboxylase affect the oligomer assembly and catalysis: expression and characterization of seven patient-derived mutant forms of PCC in Escherichia coli
Mol. Genet. Metab.
71
623-632
2000
Homo sapiens
Manually annotated by BRENDA team
Muro, S.; Perez, B.; Desviat, L.R.; Rodriguez-Pombo, P.; Perez-Cerda, C.; Clavero, S.; Ugarte, M.
Effect of PCCB gene mutations on the heteromeric and homomeric assembly of propionyl-CoA carboxylase
Mol. Genet. Metab.
74
476-483
2001
Homo sapiens
Manually annotated by BRENDA team
Diacovich, L.; Mitchell, D.L.; Pham, H.; Gago, G.; Melgar, M.M.; Khosla, C.; Gramajo, H.; Tsai, S.C.
Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity
Biochemistry
43
14027-14036
2004
Streptomyces coelicolor
Manually annotated by BRENDA team
Rodriguez-Pombo, P.; Perez-Cerda, C.; Perez, B.; Desviat, L.R.; Sanchez-Pulido, L.; Ugarte, M.
Towards a model to explain the intragenic complementation in the heteromultimeric protein propionyl-CoA carboxylase
Biochim. Biophys. Acta
1740
489-498
2005
Homo sapiens
Manually annotated by BRENDA team
Jiang, H.; Rao, K.S.; Yee, V.C.; Kraus, J.P.
Characterization of four variant forms of human propionyl-CoA carboxylase expressed in Escherichia coli
J. Biol. Chem.
280
27719-27727
2005
Homo sapiens
Manually annotated by BRENDA team
Dunn, M.F.; Araiza, G.; Mora, J.
Biochemical characterization of a Rhizobium etli monovalent cation-stimulated acyl-coenzyme A carboxylase with a high substrate specificity constant for propionyl-coenzyme A
Microbiology
150
399-406
2004
Agrobacterium tumefaciens, Azorhizobium caulinodans, Bradyrhizobium japonicum, Mesorhizobium loti, Rhizobium etli, Sinorhizobium fredii, Rhizobium leguminosarum bv. viciae, Sinorhizobium meliloti, Rhizobium tropici, Mesorhizobium huakuii, Rhizobium leguminosarum bv. viciae MNF300, Azorhizobium caulinodans ORS 571, Agrobacterium tumefaciens IAM13299, Bradyrhizobium japonicum USDA 110, Sinorhizobium fredii USDA205, Sinorhizobium meliloti Rm1021, Mesorhizobium loti NZP2037, Mesorhizobium huakuii CCBAU2609
Manually annotated by BRENDA team
Stratton, S.L.; Bogusiewicz, A.; Mock, M.M.; Mock, N.I.; Wells, A.M.; Mock, D.M.
Lymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans
Am. J. Clin. Nutr.
84
384-388
2006
Homo sapiens
Manually annotated by BRENDA team
Mutka, S.C.; Bondi, S.M.; Carney, J.R.; Da Silva, N.A.; Kealey, J.T.
Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae
FEMS Yeast Res.
6
40-47
2006
Streptomyces coelicolor
Manually annotated by BRENDA team
Lin, Y.L.; Hsueh, Y.P.
Neurofibromin interacts with CRMP-2 and CRMP-4 in rat brain
Biochem. Biophys. Res. Commun.
369
747-752
2008
Rattus norvegicus
Manually annotated by BRENDA team
Hofherr, S.; Senac, J.S.; Chen, C.Y.; Palmer, D.; Ng, P.; Barry, M.A.
Short-term rescue of neonatal lethality in a mouse model of propionic acidemia by gene therapy
Hum. Gene Ther.
20
169-180
2009
Mus musculus
Manually annotated by BRENDA team
Zhang, H.; Boghigian, B.A.; Pfeifer, B.A.
Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli
Biotechnol. Bioeng.
105
567-573
2010
Streptomyces coelicolor
Manually annotated by BRENDA team
Mo, S.; Ban, Y.H.; Park, J.W.; Yoo, Y.J.; Yoon, Y.J.
Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor
J. Ind. Microbiol. Biotechnol.
36
1473-1482
2009
Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Manually annotated by BRENDA team
Lee, T.M.; Addonizio, L.J.; Barshop, B.A.; Chung, W.K.
Unusual presentation of propionic acidaemia as isolated cardiomyopathy
J. Inherit. Metab. Dis.
23
S97-101
2009
Homo sapiens
Manually annotated by BRENDA team
Ballhausen, D.; Mittaz, L.; Boulat, O.; Bonafe, L.; Braissant, O.
Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain
Neuroscience
164
578-587
2009
Rattus norvegicus (P14882)
Manually annotated by BRENDA team
Sato, S.; Kasahara, M.; Fukuda, A.; Mizuguchi, K.; Nakagawa, S.; Muguruma, T.; Saito, O.; Karaki, C.; Nakagawa, A.; Yoshii, K.; Horikawa, R.
Liver transplantation in a patient with propionic acidemia requiring extra corporeal membrane oxygenation during severe metabolic decompensation
Pediatr. Transplant.
13
790-793
2009
Homo sapiens
Manually annotated by BRENDA team
Jung, W.S.; Yoo, Y.J.; Park, J.W.; Park, S.R.; Han, A.R.; Ban, Y.H.; Kim, E.J.; Kim, E.; Yoon, Y.J.
A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253
Appl. Microbiol. Biotechnol.
91
1389-1397
2011
Streptomyces hygroscopicus, Streptomyces hygroscopicus ATCC 29253
Manually annotated by BRENDA team
Arabolaza, A.; Shillito, M.E.; Lin, T.W.; Diacovich, L.; Melgar, M.; Pham, H.; Amick, D.; Gramajo, H.; Tsai, S.C.
Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor
Biochemistry
49
7367-7376
2010
Streptomyces coelicolor (Q9X4K7), Streptomyces coelicolor
Manually annotated by BRENDA team
Demirev, A.V.; Khanal, A.; Hanh, N.P.; Nam, K.T.; Nam, D.H.
Biochemical characteristization of propionyl-coenzyme A carboxylase complex of Streptomyces toxytricini
J. Microbiol.
49
407-412
2011
Streptomyces toxytricini
Manually annotated by BRENDA team
Huang, C.; Sadre-Bazzaz, K.; Shen, Y.; Deng, B.; Zhou, Z.; Tong, L.
Crystal structure of the alpha6beta6 holoenzyme of propionyl-coenzyme A carboxylase
Nature
466
1001-1005
2010
Ruegeria pomeroyi, Ruegeria pomeroyi (Q5LUF3)
Manually annotated by BRENDA team
Chuakrut, S.; Arai, H.; Ishii, M.; Igarashi, Y.
Characterization of a bifunctional archaeal acyl coenzyme A carboxylase
J. Bacteriol.
185
938-947
2003
Acidianus brierleyi (Q877I4 and Q877I3 and Q877I5), Acidianus brierleyi
Manually annotated by BRENDA team
Peng, N.; Zhong, Y.; Zhang, Q.; Zheng, M.; Zhao, W.; Jiang, H.; Yang, C.; Guo, X.; Zhao, G.
Characterization of acetyl-CoA and propionyl-CoA carboxylases encoded by Leptospira interrogans serovar Lai: an initial biochemical study for leptospiral gluconeogenesis via anaplerotic CO(2) assimilation
Acta Biochim. Biophys. Sin.
44
692-702
2012
Leptospira interrogans
Manually annotated by BRENDA team
Lee, M.R.; Kim, Y.J.; Kim, D.W.; Yoo, W.G.; Cho, S.H.; Hwang, K.Y.; Ju, J.W.; Lee, W.J.
The identification of antigenic proteins: 14-3-3 protein and propionyl-CoA carboxylase in Clonorchis sinensis
Mol. Biochem. Parasitol.
182
1-6
2012
Clonorchis sinensis
Manually annotated by BRENDA team
Hou, J.; Xiang, H.; Han, J.
Propionyl-CoA carboxylase in Haloferax mediterranei: indispensability for propionyl-CoA assimilation and impacts on global metabolism
Appl. Environ. Microbiol.
81
794-804
2015
Haloferax mediterranei (I3R7G3 and I3R7F1 and I3R7F2), Haloferax mediterranei
Manually annotated by BRENDA team
Liu, Y.N.; Liu, T.T.; Fan, Y.L.; Niu, D.M.; Chien, Y.H.; Chou, Y.Y.; Lee, N.C.; Hsiao, K.J.; Chiu, Y.H.
Measuring propionyl-CoA carboxylase activity in phytohemagglutinin stimulated lymphocytes using high performance liquid chromatography
Clin. Chim. Acta
453
13-20
2016
Homo sapiens
Manually annotated by BRENDA team
Vandova, G.; OBrien, R.; Lowry, B.; Robbins, T.; Fischer, C.; Davis, R.; Khosla, C.; Harvey, C.; Hillenmeyer, M.
Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli
J. Antibiot.
70
859-863
2017
Streptomyces coelicolor (Q9X4K7)
Manually annotated by BRENDA team
Chapman, K.; Ostrovsky, J.; Rao, M.; Dingley, S.; Polyak, E.; Yudkoff, M.; Xiao, R.; Bennett, M.; Falk, M.
Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism
J. Inherit. Metab. Dis.
41
157-168
2017
Caenorhabditis elegans (Q19842 and Q20676), Caenorhabditis elegans
Manually annotated by BRENDA team
Collard, R.; Majtan, T.; Park, I.; Kraus, J.P.
Import of TAT-conjugated propionyl-CoA carboxylase using models of propionic acidemia
Mol. Cell. Biol.
38
e00491
2018
Homo sapiens (P05166 and P05165)
Manually annotated by BRENDA team