6.3.4.15: biotin-[biotin carboxyl-carrier protein] ligase

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For detailed information about biotin-[biotin carboxyl-carrier protein] ligase, go to the full flat file.

Reaction

Synonyms

Acetyl CoA holocarboxylase synthetase, Acetyl coenzyme A holocarboxylase synthetase, bacterial BirA biotin ligase, biotin acetyl-CoA carboxylase ligase, Biotin holoenzyme synthetase, biotin ligase, biotin protein ligase, Biotin--protein ligase, biotin-protein ligase, Biotin-[acetyl coenzyme A carboxylase] synthetase, Biotin-[acetyl-CoA carboxylase] synthetase, Biotin:apocarboxylase ligase, BirA, BirA protein, BPL, group I biotin protein ligase, HCS, Holocarboxylase synthetase, holocarboxylase synthetase 1, More, STK_15250, Synthetase, biotin-[acetyl coenzyme A carboxylase], yBL

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.15 biotin-[biotin carboxyl-carrier protein] ligase

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Results	in table
32398	AA Sequence
16	Application
1	CAS Registry Number
38	Cloned(Commentary)
68	Cofactor
14	Crystallization (Commentary)
24	Disease/ Diagnostics
16	General Information
3	IC50 Value
28	Inhibitors
13	kcat/KM [mM/s]
13	Ki Value [mM]
53	KM Value [mM]
10	Localization
30	Metals/Ions
17	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
411	Organism
5	Pathway
94	PDB ID
9	pH Optimum
68	Protein Variants
31	Purification (Commentary)
4	Reaction
3	Reaction Type
99	Reference
15	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
149	Substrates and Products (Substrate)
30	Subunits
140	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
6	Temperature Stability [°C]
39	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 6.3.4.15 - biotin-[biotin carboxyl-carrier protein] ligase

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

26000

Pyrococcus horikoshii

O57883

2 * 26000, calculated. Equilibrium analytical ultracentrifugation measurements performed on the apoenzyme and its complexes with biotin and bio-5-AMP all yield molecular weights for the protein consistent with a dimer. Regardless of ligation state the Pyrococcus horikoshii enzyme is a dimer

714197

26071

Pyrococcus horikoshii

-

2 * 26071 recombinant enzyme, SDS-PAGE and amino acid sequence calculation

663526

265000

Homo sapiens

-

acetyl-CoA carboxylase-1

691104

26630

Sulfurisphaera tokodaii

F9VNG7

MALDI TOF mass spectrometry

724993

29500

Mycobacterium tuberculosis

-

monomeric enzyme, gel filtration

689712

35000

Escherichia coli

-

x * 35000, recombinant enzyme, SDS-PAGE

664436

35300

Escherichia coli

-

SDS-PAGE

653788

35310

Escherichia coli

-

MALDI TOF mass spectrometry

724993

35500

Escherichia coli K-12

P06709

SDS-PAGE

695558

38300

Staphylococcus aureus

-

2 * 38300, calculated from amino acid sequence

728338

51200

Pyrococcus horikoshii

O57883

sedimentation equilibrium study

714197

53900

Pyrococcus horikoshii

-

recombinant enzyme, light scattering study

663526

56000

Mycobacterium tuberculosis

-

dimeric enzyme, gel filtration

689712

73000

Candida albicans

-

x * 73000, recombinant His9-tagged BPL, SDS-PAGE

690627

76000

Staphylococcus aureus

-

sedimentation equilibrium analysis

728338

7909

Pyrococcus horikoshii

-

liquid-chromatography electrospray ionisation ion-trap mass spectroscopy

671127

82000

Homo sapiens

-

SDS-PAGE

675570