6.3.4.10: biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

This is an abbreviated version!
For detailed information about biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase, go to the full flat file.

Word Map on EC 6.3.4.10

Reaction

ATP
+
biotin
+
apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
=
AMP
+
diphosphate
+
[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]

Synonyms

Synthetase, biotin-propionyl coenzyme A carboxylase, Biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase, Biotin-propionyl coenzyme A carboxylase synthetase, Propionyl coenzyme A holocarboxylase synthetase, HCS, Holocarboxylase synthetase, biotin protein ligase, BPL, HLCS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.10 biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

Substrates Products

Substrates Products on EC 6.3.4.10 - biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + biotin + apo-beta-methylcrotonyl-CoA carboxylase
AMP + diphosphate + holo-beta-methylcrotonyl-CoA carboxylase
show the reaction diagram
-
-
-
-
?
ATP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
?
show the reaction diagram
ATP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
AMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
ATP + biotin + apo-[propionyl CoA carboxylase]
AMP + diphosphate + propionyl CoA carboxylase
show the reaction diagram
-
-
-
-
?
ATP + biotin + apo-[propionyl-CoA carboxylase]
AMP + diphosphate + propionyl-CoA carboxylase
show the reaction diagram
ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
AMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
-
-
-
-
?
ATP + biotin + apoacetyl-CoA carboxylase
AMP + diphosphate + holoacetyl-CoA carboxylase
show the reaction diagram
-
biotinylation of cytosolic ACC
-
-
?
ATP + biotin + apocarboxyl carrier protein
AMP + diphosphate + holocarboxyl carrier protein
show the reaction diagram
-
HCS catalyzes the incorporation of biotin into carboxylases, recombinant apo-CCP from Escherichia coli
-
-
?
ATP + biotin + apocarboxylase
AMP + diphosphate + holocarboxylase
show the reaction diagram
-
-
-
-
?
ATP + biotin + apopropionyl-CoA carboxylase
AMP + diphosphate + holopropionyl-CoA carboxylase
show the reaction diagram
-
biotinylation of mitochondrial PCC
-
-
?
ATP + biotin + apopyruvate carboxylase
AMP + diphosphate + holopyruvate carboxylase
show the reaction diagram
-
-
-
-
?
ATP + biotin + BCCP87
AMP + diphosphate + biotin-BCCP87
show the reaction diagram
-
substrate is the biotinoyl domain, BCCP87, of Escherichia coli biotin carboxyl carrier protein, BCCP, binding pattern, overview
-
-
?
ATP + biotin + histone H2A
AMP + diphosphate + biotin-histone H2A
show the reaction diagram
-
pattern of biotin attachment and comparison to nonenzymatic biotinylation of histone H2A, none of the lysine sites within histone H2A resembles the biotin attachment consensus sequence seen in carboxylases, mechanism, overview. H2A is a poor substrate for biotin attachment compared to the apocarboxylase biotin-attachment domain
-
-
?
ATP + biotin + histone H3.2
AMP + diphosphate + biotin-histone H3.2
show the reaction diagram
-
-
biotinylation of residues K9 and K18 in histone H3
-
?
ATP + biotin + histone H3.2 N-terminal amino acids 1-25
AMP + diphosphate + biotin-histone H3.2 N-terminal amino acids 1-25
show the reaction diagram
-
-
biotinylation of residues K9 and K18
-
?
ATP + biotin + histone H4
AMP + diphosphate + biotin-histone H4
show the reaction diagram
-
biotinylation at Lys12 especially in telomeric repeats, overview
-
-
?
ATP + biotin + p67
AMP + diphosphate + biotinyl-p67
show the reaction diagram
-
comprises the 67 C-terminal amino acids in human propionyl-CoA carboxylase, including the biotin-binding site lysine-669
-
-
?
ATP + biotin + protein Syn67
AMP + diphosphate + protein Syn67-biotin
show the reaction diagram
-
mutated Syn67, both N- and C-termini of HCS interact with Syn67, a polypeptide with a basic patch of lysines and arginines, and the Syn67 docking site is located near the active pocket of HCS. The target lysine in Syn67 is biotinylated by HCS only after arginine-to-glycine substitutions in Syn67 produce a histone-like peptide, binding structure, modelling, overview
-
-
?
biotinyl-5'-AMP + apocarboxylase
AMP + holocarboxylase
show the reaction diagram
-
-
-
-
?
CTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
CMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
CTP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
CMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
-
CTP can totally replace ATP
-
-
?
GTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
GMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
GTP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
GMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
-
GTP is approximately half as active as ATP
-
-
?
ITP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
IMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
ITP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
IMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
-
ITP is approximately half as active as ATP
-
-
?
UTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
UMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
show the reaction diagram
additional information
?
-