6.3.4.10: biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

This is an abbreviated version!
For detailed information about biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase, go to the full flat file.

Word Map on EC 6.3.4.10

Reaction

ATP
+
biotin
+
apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
=
AMP
+
diphosphate
+
[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]

Synonyms

Synthetase, biotin-propionyl coenzyme A carboxylase, Biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase, Biotin-propionyl coenzyme A carboxylase synthetase, Propionyl coenzyme A holocarboxylase synthetase, HCS, Holocarboxylase synthetase, biotin protein ligase, BPL, HLCS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.10 biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

Expression

Expression on EC 6.3.4.10 - biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
evolutionary conserved binding site for microRNA miR-539 in the 3'-untranslated region of HCS mRNA. miR-539 decreases the expression of HCS at the level of transcription rather than translation. When miR-539 is overexpressed in transgenic cells, the abundance of both HCS and biotinylated histones decreases. The abundance of miR-539 is tissue dependent, decreasing in the order fibroblasts, kidney cells, intestinal cells, lymphoid cells. The abundance of miR-539 is significantly higher at physiological concentrations of biotin than both biotin-deficient and biotin-supplemented media in all cell lines tested
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