6.3.4.10: biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

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Reaction

Synonyms

biotin protein ligase, Biotin-propionyl coenzyme A carboxylase synthetase, Biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase, BPL, HCS, HLCS, Holocarboxylase synthetase, Propionyl coenzyme A holocarboxylase synthetase, Synthetase, biotin-propionyl coenzyme A carboxylase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.10 biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

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Results	in table
38	AA Sequence
8	Application
1	CAS Registry Number
14	Cloned(Commentary)
8	Cofactor
827	Disease/ Diagnostics
1	Expression
17	General Information
2	General Stability
3	Inhibitors
14	KM Value [mM]
18	Localization
7	Metals/Ions
10	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
39	Organism
2	Pathway
4	pH Optimum
11	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
38	Reference
25	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
72	Substrates and Products (Substrate)
8	Subunits
41	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]

Expression

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Expression on EC 6.3.4.10 - biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

evolutionary conserved binding site for microRNA miR-539 in the 3'-untranslated region of HCS mRNA. miR-539 decreases the expression of HCS at the level of transcription rather than translation. When miR-539 is overexpressed in transgenic cells, the abundance of both HCS and biotinylated histones decreases. The abundance of miR-539 is tissue dependent, decreasing in the order fibroblasts, kidney cells, intestinal cells, lymphoid cells. The abundance of miR-539 is significantly higher at physiological concentrations of biotin than both biotin-deficient and biotin-supplemented media in all cell lines tested

Homo sapiens

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