6.3.3.3: dethiobiotin synthase

This is an abbreviated version!
For detailed information about dethiobiotin synthase, go to the full flat file.

Reaction

Synonyms

BIO3, BioD, BioD1, Desthiobiotin synthetase, Dethiobiotin synthase, Dethiobiotin synthetase, DTB synthetase, DTBS, Synthetase, dethiobiotin

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.3 Cyclo-ligases

                6.3.3.3 dethiobiotin synthase

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Results	in table
23520	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
1	Cofactor
12	Crystallization (Commentary)
9	IC50 Value
28	Inhibitors
3	Ki Value [mM]
43	KM Value [mM]
1	Localization
9	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
42	Organism
6	Pathway
158	PDB ID
2	pH Optimum
6	Protein Variants
9	Purification (Commentary)
7	Reaction
2	Reaction Type
42	Reference
2	Source Tissue
6	Specific Activity [micromol/min/mg]
2	Storage Stability
86	Substrates and Products (Substrate)
6	Subunits
16	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
28	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.9 - 49

(7R,8S)-7,8-diaminopelargonic acid

5 entries

1.3 - 38.6

ATP

5 entries

1 - 28.1

CTP

5 entries

1.2 - 29

GTP

5 entries

10.2

ITP

Mycobacterium tuberculosis

P9WPQ5

wild-type, pH 7.5, 37°C

746545

1.7 - 38.4

NaHCO3

5 entries

11.8

TTP

Mycobacterium tuberculosis

P9WPQ5

wild-type, pH 7.5, 37°C

746545

11.4

UTP

Mycobacterium tuberculosis

P9WPQ5

wild-type, pH 7.5, 37°C

746545

0.9

(7R,8S)-7,8-diaminopelargonic acid

Mycobacterium tuberculosis

P9WPQ5

mutant G169N, pH 7.5, 37°C

746545

0.9

(7R,8S)-7,8-diaminopelargonic acid

Escherichia coli

P13000

mutant N175A, pH 7.5, 37°C

746545

13.3

(7R,8S)-7,8-diaminopelargonic acid

Mycobacterium tuberculosis

P9WPQ5

wild-type, pH 7.5, 37°C

746545

23.2

(7R,8S)-7,8-diaminopelargonic acid

Escherichia coli

P13000

mutant N175G, pH 7.5, 37°C

746545

49

(7R,8S)-7,8-diaminopelargonic acid

Escherichia coli

P13000

wild-type, pH 7.5, 37°C

746545

1.3

ATP

Mycobacterium tuberculosis

P9WPQ5

mutant G169N, pH 7.5, 37°C

746545

11.7

ATP

Mycobacterium tuberculosis

P9WPQ5

wild-type, pH 7.5, 37°C

746545

18.1

ATP

Escherichia coli

P13000

mutant N175A, pH 7.5, 37°C

746545

23.6

ATP

Escherichia coli

P13000

mutant N175G, pH 7.5, 37°C

746545

38.6

ATP

Escherichia coli

P13000

wild-type, pH 7.5, 37°C

746545

1

CTP

Mycobacterium tuberculosis

P9WPQ5

mutant G169N, pH 7.5, 37°C

746545

15.2

CTP

Mycobacterium tuberculosis

P9WPQ5

wild-type, pH 7.5, 37°C

746545

19.1

CTP

Escherichia coli

P13000

mutant N175A, pH 7.5, 37°C

746545

19.6

CTP

Escherichia coli

P13000

mutant N175G, pH 7.5, 37°C

746545

28.1

CTP

Escherichia coli

P13000

wild-type, pH 7.5, 37°C

746545

1.2

GTP

Mycobacterium tuberculosis

P9WPQ5

mutant G169N, pH 7.5, 37°C

746545

11.1

GTP

Mycobacterium tuberculosis

P9WPQ5

wild-type, pH 7.5, 37°C

746545

16.3

GTP

Escherichia coli

P13000

mutant N175G, pH 7.5, 37°C

746545

18.3

GTP

Escherichia coli

P13000

mutant N175A, pH 7.5, 37°C

746545

29

GTP

Escherichia coli

P13000

wild-type, pH 7.5, 37°C

746545

1.7

NaHCO3

Mycobacterium tuberculosis

P9WPQ5

mutant G169N, pH 7.5, 37°C

746545

9.9

NaHCO3

Mycobacterium tuberculosis

P9WPQ5

wild-type, pH 7.5, 37°C

746545

15.4

NaHCO3

Escherichia coli

P13000

mutant N175G, pH 7.5, 37°C

746545

16.2

NaHCO3

Escherichia coli

P13000

mutant N175A, pH 7.5, 37°C

746545

38.4

NaHCO3

Escherichia coli

P13000

wild-type, pH 7.5, 37°C

746545