6.3.3.3: dethiobiotin synthase
This is an abbreviated version!
For detailed information about dethiobiotin synthase, go to the full flat file.
Word Map on EC 6.3.3.3
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6.3.3.3
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7,8-diaminopelargonic
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aminotransferase
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dapas
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penultimate
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ureido
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carbamate
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diaminopelargonic
- 6.3.3.3
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7,8-diaminopelargonic
- aminotransferase
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dapas
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penultimate
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ureido
- carbamate
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diaminopelargonic
Reaction
Synonyms
BIO3, BioD, BioD1, Desthiobiotin synthetase, Dethiobiotin synthase, Dethiobiotin synthetase, DTB synthetase, DTBS, Synthetase, dethiobiotin
ECTree
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Reaction
Reaction on EC 6.3.3.3 - dethiobiotin synthase
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the final intermediate is the phosphoric acid anhydride of the carbamate
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ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin
mechanistic model in which binding of Mg2+ and the triphosphate element of ATP to the enzyme creates the appropriate geometry for substrate 7,8-diaminononanoate-binding and carbamate formation
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ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin
8-aminocarbamate of (7R,8S)-7,8 diaminononanoate is an enzyme-bound intermediate
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ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin
the carbonylation of 7,8-diaminononanoic acid proceeds regiospecifically via the N7-carbamate
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ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin
enzyme reaction involves three steps: carbamylation of theN7 position of 7,8-diaminononanoate, formation of a carbamate-phosphoric anhydride intermediate, and, closure of the ureido ring to form dethiobiotin and release of the inorganic phosphate
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