6.3.2.9: UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase, go to the full flat file.

Reaction

Synonyms

D-Glutamate-adding enzyme, D-glutamic acid adding enzyme, D-Glutamic acid-adding enzyme, MurD, MurD cell wall enzyme, MurD ligase, Synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamate, UDP-Mur-Nac-L-Ala:L-Glu ligase, UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase, UDP-N-acetylmuramoyl-L-alanine:D-glutamateligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase, UDPMurNAc-L-alanine:D-glutamate ligase (ADP-forming), Uridine diphosphate N-acetylmuramoyl-L-alanine:D-glutamate ligase, Uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.9 UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase

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Results	in table
39654	AA Sequence
3	Application
1	CAS Registry Number
9	Cloned(Commentary)
5	Cofactor
11	Crystallization (Commentary)
3	General Information
37	IC50 Value
90	Inhibitors
11	Ki Value [mM]
62	KM Value [mM]
7	Localization
22	Metals/Ions
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
171	Organism
7	Pathway
33	PDB ID
11	pH Optimum
2	Posttranslational Modification
22	Protein Variants
9	Purification (Commentary)
4	Reaction
2	Reaction Type
50	Reference
5	Source Tissue
5	Specific Activity [micromol/min/mg]
9	Storage Stability
49	Substrates and Products (Substrate)
3	Subunits
22	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
20	Turnover Number [1/s]

General Information

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General Information on EC 6.3.2.9 - UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Escherichia coli

P14900

the enzyme is involved in the peptidoglycan biosynthesis

746203

physiological function

Escherichia coli

P14900

MurD catalyzes the addition of D-glutamic acid to UDP-MurNAc-L-Ala, generating the dipeptide moiety L-Ala-D-Glu in peptidoglycan biosynthesis

746203

additional information

Escherichia coli

P14900

conformational changes of MurD occur upon ligand binding. Upon binding of ATP and UDP-N-acetyl-alpha-D-muramoyl-L-alanine, there is a closing rotation of the C-terminal domain, which does not occur before ATP is bound, targeted molecular dynamics simulation

746203