6.3.2.3: glutathione synthase

This is an abbreviated version!
For detailed information about glutathione synthase, go to the full flat file.

Word Map on EC 6.3.2.3

Reaction

ATP
+
gamma-L-glutamyl-L-cysteine
+
glycine
=
ADP
+
phosphate
+
glutathione

Synonyms

More, Glutathione synthetase, Synthetase, glutathione, GSH synthetase, Glutathione synthetase (tripeptide), GSS, GS, Glutathione synthase, GSHase, Phytochelatin synthetase, gamma-GCS, GCL, GSHS1, GSHS, glutamate cysteine ligase, gamma-GCS-GS, GshF, ZmGS, gamma -glutamate-cysteine ligase-glutathione synthetase, GSH-S, TAGS1, TaGS2, gamma-glutamate-cysteine ligase/glutathione synthetase, gamma-glutamylcysteine synthetase-glutathione synthetase, GSH2, GSH synthase, hGS, StGCL-GS, TbGS, gshB, bifunctional L-glutathione synthetase, Asuc_1947, gshAB, GshFAp, glutathione biosynthesis bifunctional protein GshAB, GshFAs, bifunctional glutathione synthetase, GCSGS, bifunctional GSH synthetase, ghF, GSHII, L-glutathione synthetase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.3 glutathione synthase

Specific Activity

Specific Activity on EC 6.3.2.3 - glutathione synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0006
-
crude extract and cytosolic fraction of leaves
0.0008
-
mitochondrial fraction of leaves
0.0039
-
cell line OC/CDE22, GSH depleted
0.0047
-
cell line M22
0.0064
-
cell line OC/CDE22
0.0078
-
cell line M22, GSH depleted
0.0094
bacteroid isolate
0.0127
-
bacteroid isolate
0.033
-
-
11
-
purified recombinant enzyme
17.2
-
purified recombinant wild-type enzyme after complete proteoltic cleavage
17.3
-
purified recombinant isolated subfragments of 24 and 36 kDa
19.3
-
purified recombinant deletion mutant lacking 15 amino acids
20.1
-
purified recombinant wild-type enzyme
21.9
-
purified recombinant enzyme mutant with eliminated cleavage site
29.95
-
pH 8.2, 37°C
3 - 8
-
about, wild-type mice on minimal diet
32
-
about, ApoE-deficient mice on normal diet
33.5
-
about, wild-type mice on normal diet
43
-
about, ApoE-deficient mice on minimal diet
additional information