6.3.2.3: glutathione synthase

This is an abbreviated version!
For detailed information about glutathione synthase, go to the full flat file.

Reaction

Synonyms

Asuc_1947, bifunctional glutathione synthetase, bifunctional GSH synthetase, bifunctional L-glutathione synthetase, gamma -glutamate-cysteine ligase-glutathione synthetase, gamma-GCS, gamma-GCS-GS, gamma-glutamate-cysteine ligase/glutathione synthetase, gamma-glutamylcysteine synthetase-glutathione synthetase, GCL, GCSGS, ghF, glutamate cysteine ligase, glutathione biosynthesis bifunctional protein GshAB, Glutathione synthase, Glutathione synthetase, Glutathione synthetase (tripeptide), GS, GSH synthase, GSH synthetase, GSH-S, GSH2, gshAB, GSHase, gshB, GshF, GshFAp, GshFAs, GSHII, GSHS, GSHS1, GSS, hGS, L-glutathione synthetase, More, Phytochelatin synthetase, StGCL-GS, Synthetase, glutathione, TAGS1, TaGS2, TbGS, ZmGS

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.3 glutathione synthase

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Results	in table
15	Activating Compound
21524	AA Sequence
8	Application
1	CAS Registry Number
64	Cloned(Commentary)
43	Cofactor
13	Crystallization (Commentary)
527	Disease/ Diagnostics
2	Expression
28	General Information
6	General Stability
1	IC50 Value
82	Inhibitors
9	kcat/KM [mM/s]
19	Ki Value [mM]
216	KM Value [mM]
19	Localization
62	Metals/Ions
40	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
1904	Organism
7	Pathway
29	PDB ID
35	pH Optimum
1	pH Range
2	pH Stability
4	pI Value
7	Posttranslational Modification
99	Protein Variants
32	Purification (Commentary)
9	Reaction
2	Reaction Type
141	Reference
74	Source Tissue
39	Specific Activity [micromol/min/mg]
10	Storage Stability
241	Substrates and Products (Substrate)
36	Subunits
139	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
1	Temperature Range [°C]
20	Temperature Stability [°C]
103	Turnover Number [1/s]

General Stability

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General Stability on EC 6.3.2.3 - glutathione synthase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

glycerol is required for stabilization of the enzyme during freezing

Rattus norvegicus

-

650833

loss of activity by exposure to Mn2+ for long periods

Rattus norvegicus

-

1194

proteolysis by arginyl endopeptidase or trypsin causes a time-dependent decrease in activity. Only one peptide bond between Arg233 and Gly234 in the loop is cleaved

Escherichia coli

-

1220

relatively stable at all stages of purification

Escherichia coli

-

1192

several successive freezings and thawings of the cell-free extract have no effect on enzyme activity

Escherichia coli

-

1196

the remaining activity after arginyl-endopeptidase treatment is higher in the presence of ATP and/or gamma-Glu-Cys than in their absence

Escherichia coli

-

1218