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6.3.2.2: glutamate-cysteine ligase

This is an abbreviated version!
For detailed information about glutamate-cysteine ligase, go to the full flat file.

Word Map on EC 6.3.2.2

Reaction

ATP
+
L-glutamate
+
L-cysteine
=
ADP
+
phosphate
+
gamma-L-glutamyl-L-cysteine

Synonyms

Ace-GCL, Asuc_1947, AtGCL, bifunctional glutathione synthetase, bifunctional GSH synthetase, bifunctional L-glutathione synthetase, gamma -GCS, gamma-ECL, Gamma-ECS, gamma-GC, gamma-GCS, gamma-GCS-GS, gamma-glutamate-cysteine ligase-glutathione synthetase, gamma-glutamate-cysteine ligase/glutathione synthetase, gamma-glutaminylcysteine synthetase, gamma-glutamycysteine synthetase, gamma-glutamyl-cysteine ligase, gamma-Glutamyl-L-cysteine synthetase, gamma-glutamylcysteine ligase, gamma-glutamylcysteine synthase, gamma-Glutamylcysteine synthetase, gamma-glutamylcysteine synthetase-glutathione synthetase, gamma-Glutamylcysteinyl-synthetase, gammaGCS, GCL, GCLC, Gclc-X2, GCLM, GCS, GCSGS, ghF, GLCL, GLCLC, GLCLR, glutamate cysteine ligase, glutamate cysteine ligase gene, glutamate-cysteine ligase, glutamate-cysteine-ligase, glutamate–cysteine ligase, glutathione biosynthesis bifunctional protein GshAB, GSH1, GshA, gshAB, GshF, GshFAp, GshFAs, GSHI, I79_022778, L-glutamate L-cysteine ligase, More, PAD2, PhGshA II, PSHAa0937, StGCL-GS, Synthetase, gamma-glutamylcysteine

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.2 glutamate-cysteine ligase

KI Value

KI Value on EC 6.3.2.2 - glutamate-cysteine ligase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0089
(2S)-2-amino-4-[(2R,S)-2-carboxy-3-hydroxypropyl-(R,S)-sulfonimidoyl]butanoic acid
-
pH 7.5, 37°C
9.2
(2S)-2-amino-4-[(2R,S)-2-carboxy-3-phenylpropyl-(R,S)-sulfonimidoyl]butanoic acid
-
pH 7.5, 37°C
0.0000099 - 0.00059
(2S)-2-amino-4-[(2R,S)-2-carboxybutyl-(R,S)-sulfonimidoyl]butanoic acid
0.023
(2S)-2-amino-4-[(2R,S)-2-carboxyhexyl-(R,S)-sulfonimidoyl]butanoic acid
-
pH 7.5, 37°C
3.9
(2S)-2-amino-4-[(2R,S)-2-carboxyoctyl-(R,S)-sulfonimidoyl]butanoic acid
-
pH 7.5, 37°C
0.0014
(2S)-2-amino-4-[(2R,S)-2-carboxypropyl-(R,S)-sulfonimidoyl]butanoic acid
-
pH 7.5, 37°C
0.053
(2S)-2-amino-4-[2-carboxyethyl-(R,S)-sulfonimidoyl]butanoic acid
-
pH 7.5, 37°C
2.5
4-methylene-L-glutamate
-
7.75
5-Chloro-4-oxo-L-norvaline
-
0.06
buthionine sulfone
-
1.2
buthionine sulfoximine
pH 7.0, 25°C, mutant DELTA85
0.0039 - 11
cystamine
7.6 - 24.3
gamma-glutamylcysteine
2.12
gamma-L-Glu-L-Cys
wild-type, pH 8.0
0.72 - 13.6
glutathione
0.033 - 1000
GSH
29.3
L-buthionine sulfoximine
-
-
0.00013
L-buthionine-R,S-sulfoximine
pH 8.0, 37°C
0.15
L-buthionine-R-sulfoximine
-
0.1 - 4.9
L-buthionine-S-sulfoximine
0.049
L-buthionine-SR-sulfoximine
-
pH 7.5, 37°C
3.93 - 4.7
L-Glu
12.5
ophthalmic acid
noncompetitive
2.7
S-sulfo-homocysteine
-
additional information
additional information
-