6.3.2.16: D-alanine-alanyl-poly(glycerolphosphate) ligase

This is an abbreviated version!
For detailed information about D-alanine-alanyl-poly(glycerolphosphate) ligase, go to the full flat file.

Reaction

ATP
+
D-alanine
+
alanyl-poly(glycerolphosphate)
=
ADP
+
phosphate
+
D-alanyl-alanyl-poly(glycerolphosphate)

Synonyms

D-Alanyl-alanyl-polyglycerolphosphate synthetase, D-Alanine:membrane-acceptor ligase, Synthetase, D-alanylalanylpoly(phosphoglycerol), D-Alanyl-poly(phosphoglycerol) synthetase, D-Alanine-membrane acceptor-ligase, D-Alanine:membrane acceptor ligase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.16 D-alanine-alanyl-poly(glycerolphosphate) ligase

Substrates Products

Substrates Products on EC 6.3.2.16 - D-alanine-alanyl-poly(glycerolphosphate) ligase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ADP + D-Ala + membrane-acceptor
AMP + phosphate + D-alanyl-membrane acceptor
show the reaction diagram
-
83% of the activity relative to ATP
-
-
?
ATP + D-2-amino-n-butanoate + membrane-acceptor
ADP + phosphate + D-2-aminobutanoyl-membrane acceptor
show the reaction diagram
-
-
-
-
?
ATP + D-Ala + membrane-acceptor
?
show the reaction diagram
-
reaction is responsible for the incorporation of D-Ala into membranes of Lactobacillus casei, involved in the synthesis of teichoic acids
-
-
?
ATP + D-Ala + membrane-acceptor
ADP + phosphate + D-alanyl-membrane acceptor
show the reaction diagram
-
no activity with L-Ala
-
?
CTP + D-Ala + membrane-acceptor
CDP + phosphate + D-alanyl-membrane acceptor
show the reaction diagram
-
107% of the activity relative to ATP
-
-
?
GTP + D-Ala + membrane-acceptor
GDP + phosphate + D-alanyl-membrane acceptor
show the reaction diagram
-
84% of the activity relative to ATP
-
-
?
UTP + D-Ala + membrane-membrane acceptor
UDP + phosphate + D-alanyl-membrane acceptor
show the reaction diagram
-
126% of the activity relative to ATP
-
-
?