6.3.2.14: enterobactin synthase

This is an abbreviated version!
For detailed information about enterobactin synthase, go to the full flat file.

Reaction

6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine =

Synonyms

2,3-Dihydroxy-N-benzoyl-L-serine synthetase, 2,3-Dihydroxybenzoylserine synthetase, DBS synthetase, DHBS synthase, EntE, N-(2,3-Dihydroxybenzoyl)-serine synthetase, Synthetase, 2,3-dihydroxybenzoylserine

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.14 enterobactin synthase

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Results	in table
1119	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
1	Cofactor
1	General Information
2	Inhibitors
6	kcat/KM [mM/s]
1	Ki Value [mM]
8	KM Value [mM]
2	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
17	Organism
4	Pathway
1	pH Optimum
4	Purification (Commentary)
3	Reaction
2	Reaction Type
12	Reference
20	Substrates and Products (Substrate)
1	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
7	Turnover Number [1/s]

Reference

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Reference on EC 6.3.2.14 - enterobactin synthase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

1040

Bryce, G.F.; Weller, R.; Brot, N.

Studies on the enzymatic synthesis of 2,3-dihydroxy-N-benzoyl-L-serine in Escherichia coli

Biochem. Biophys. Res. Commun.

42

871-879

1971

Escherichia coli

4929929

brenda

1041

Bryce, G.F.; Brot, N.

Iron transport in Escherichia coli and its relation to the repression of 2,3-dihydroxy-N-benzoyl-L-serine synthetase

Arch. Biochem. Biophys.

142

399-406

1971

Escherichia coli

4927555

brenda

1042

Brot, N.; Goodwin, J.

Regulation of 2,3-dihydroxybenzoylserine synthetase by iron

J. Biol. Chem.

243

510-513

1968

Escherichia coli

4966114

brenda

1043

Brot, N.; Goodwin, J.; Fales, H.

In vivo and in vitro formation of 2,3-dihydroxybenzoylserine by Escherichia coli K12

Biochem. Biophys. Res. Commun.

25

454-461

1966

Escherichia coli, Escherichia coli 2276

5337719

brenda

1044

McCray, J.W.; Herrmann, K.M.

Derepression of certain aromatic amino acid biosynthetic enzymes of Escherichia coli K-12 by growth in Fe3+-deficient medium

J. Bacteriol.

125

608-615

1976

Escherichia coli

1383

brenda

1045

Reichert, J.; Sakaitani, M.; Walsh, C.T.

Characterization of EntF as a serine-activating enzyme

Protein Sci.

1

549-556

1992

Escherichia coli

1338974

brenda

649843

Gehring, A.M.; Mori, I.; Walsh, C.T.

Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF

Biochemistry

37

2648-2659

1998

Escherichia coli

9485415

brenda

653649

Ehmann, D.E.; Shaw-Reid, C.A.; Losey, H.C.; Walsh, C.T.

The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates

Proc. Natl. Acad. Sci. USA

97

2509-2514

2000

Escherichia coli

10688898

brenda

726950

Sikora, A.L.; Wilson, D.J.; Aldrich, C.C.; Blanchard, J.S.

Kinetic and inhibition studies of dihydroxybenzoate-AMP ligase from Escherichia coli

Biochemistry

49

3648-3657

2010

Escherichia coli (P0ADI4), Escherichia coli (P10378), Escherichia coli (P11454)

20359185

brenda

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