6.3.2.12: dihydrofolate synthase
This is an abbreviated version!
For detailed information about dihydrofolate synthase, go to the full flat file.
Word Map on EC 6.3.2.12
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6.3.2.12
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tetrahydrofolate
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polyglutamylated
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analysis
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medicine
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drug development
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biotechnology
- 6.3.2.12
- tetrahydrofolate
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polyglutamylated
- analysis
- medicine
- drug development
- biotechnology
Reaction
Synonyms
7,8-Dihydrofolate synthetase, 7,8-Dihydropteroate:L-glutamate ligase (ADP), DHFR, DHFS, dihydrofolate reductase, dihydrofolate synthase, Dihydrofolate synthetase, dihydrofolate synthetase-folylpolyglutamate synthetase, dihydropteroate:L-glutamate ligase (ADP-forming), FHFS, FHFS/FPGS, FolC, Folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, H2-folate synthetase, LH57_13380, PfDHFS-FPGS, PNEJI1_000945, Rv2447c, Synthetase, dihydrofolate
ECTree
6.3.2.12 dihydrofolate synthaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 6.3.2.12 - dihydrofolate synthase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2-[[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]phenyl)(hydroxy)phosphoryl]methyl]pentanedioic acid
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selective for dihydrofolate synthase activity
2-[[[(3S)-3-[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]benzoyl)amino]-3-carboxypropyl](hydroxy)phosphoryl]methyl]pentanedioic acid
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7,8-dihydrofolate
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noncompetitive with respect to dihydropteroate, competitive with respect to L-Glu
additional information
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5,6,7,8-tetrahydrofolate does not significantly inhibit
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additional information
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no inhibition by 10N-formyltetrahydropteroyldiglutamate
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additional information
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in Escherichia coli, the addition of L-glutamate to dihydropteroate (dihydrofolate synthetase activity) and the subsequent additions of L-glutamate to tetrahydrofolate (folylpolyglutamate synthetase (FPGS) activity) are catalyzed by the same enzyme, FolC. The presence of a folate binding site in Escherichia coli FolC, which is different from the one seen in folylpolyglutamate synthetases, provides avenues for the design of specific inhibitors of this enzyme in antimicrobial therapy
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