6.3.2.12: dihydrofolate synthase

This is an abbreviated version!
For detailed information about dihydrofolate synthase, go to the full flat file.

Word Map on EC 6.3.2.12

Reaction

ATP
+
7,8-dihydropteroate
+
L-glutamate
=
ADP
+
phosphate
+
7,8-dihydropteroylglutamate

Synonyms

7,8-Dihydrofolate synthetase, 7,8-Dihydropteroate:L-glutamate ligase (ADP), Dihydrofolate synthetase, FHFS, FHFS/FPGS, Folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, Synthetase, dihydrofolate, DHFR, H2-folate synthetase, dihydrofolate synthetase-folylpolyglutamate synthetase, DHFS, dihydropteroate:L-glutamate ligase (ADP-forming), dihydrofolate reductase, FolC, dihydrofolate synthase, PfDHFS-FPGS, PNEJI1_000945, Rv2447c, LH57_13380

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.12 dihydrofolate synthase

Inhibitors

Inhibitors on EC 6.3.2.12 - dihydrofolate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-[[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]phenyl)(hydroxy)phosphoryl]methyl]pentanedioic acid
-
selective for dihydrofolate synthase activity
2-[[[(3S)-3-[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]benzoyl)amino]-3-carboxypropyl](hydroxy)phosphoryl]methyl]pentanedioic acid
-
-
7,8-dihydrofolate
Dihydro-10-carbonylfolic acid
-
-
Dihydro-10-carbonylpteroic acid
-
-
Dihydro-10-thiofolic acid
-
-
Dihydro-10-thiopteroic acid
Dihydrofolate derivatives
-
-
-
dihydrofolic acid
dihydrohomopteroic acid
Dihydroisopteroic acid
Dihydropterin-sulfonamides
-
-
-
Dihydropteroate derivatives
-
-
-
p-hydroxymercuribenzoate
-
-
Tetrahydrohomopteroate
Serratia indica
-
-
additional information
-