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6.3.2.12: dihydrofolate synthase

This is an abbreviated version!
For detailed information about dihydrofolate synthase, go to the full flat file.

Word Map on EC 6.3.2.12

Reaction

ATP
+
7,8-dihydropteroate
 +
L-glutamate
=
ADP
 +
phosphate
 +
7,8-dihydropteroylglutamate

Synonyms

7,8-Dihydrofolate synthetase, 7,8-Dihydropteroate:L-glutamate ligase (ADP), DHFR, DHFS, dihydrofolate reductase, dihydrofolate synthase, Dihydrofolate synthetase, dihydrofolate synthetase-folylpolyglutamate synthetase, dihydropteroate:L-glutamate ligase (ADP-forming), FHFS, FHFS/FPGS, FolC, Folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, H2-folate synthetase, LH57_13380, PfDHFS-FPGS, PNEJI1_000945, Rv2447c, Synthetase, dihydrofolate

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.12 dihydrofolate synthase

Engineering

Engineering on EC 6.3.2.12 - dihydrofolate synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A132E
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
A171A
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
A420V
naturally occuring mutation in enzyme FolC in clinical isolates of both drug-resistant and drug-susceptible Mycobacterium tuberculosis
A457V
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
D111A
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
D112A
naturally occuring mutation
D135A
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
D324G
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
D384A
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
E153A
E153G
E40K
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
E434Q
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
F152L
naturally occuring conserved mutation
F152S
naturally occuring conserved mutation
F461F
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
G111S
naturally occuring mutation
G112S
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
G284G
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
G422G
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
I43F
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
I43S
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
I43V
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
N73S
naturally occuring conserved mutation
P21L
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
P356L
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
P8P
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
P9P
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
R268R
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
R410W
R49G
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
S150G
S150R
naturally occuring conserved mutation
S335I
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
V256A
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
D111A
Mycobacterium tuberculosis ATCC 25618 / H37Rv
-
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
-
D384A
Mycobacterium tuberculosis ATCC 25618 / H37Rv
-
naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis
-
E153A
Mycobacterium tuberculosis ATCC 25618 / H37Rv
-
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
-
E153G
Mycobacterium tuberculosis ATCC 25618 / H37Rv
-
naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis
-
E153A
-
naturally occuring conserved mutation, the mutant shows reduced enzyme activity
-
E153G
-
naturally occuring conserved mutation
-
R410W
-
naturally occuring mutation
-
S150R
-
naturally occuring conserved mutation
-
A183P
naturally occuring conserved mutation, the mutant shows reduced enzyme activity
R49W
naturally occuring conserved mutation, the mutant shows reduced enzyme activity
additional information