6.3.1.9: trypanothione synthase

This is an abbreviated version!
For detailed information about trypanothione synthase, go to the full flat file.

Reaction

Synonyms

Cf-TS, GenBank AF006615-derived protein GI 3004644, LdTryS, LiTRYS, Synthetase, trypanothione, Synthetase, trypanothione (Crithidia fasciculata strain HS6 gene Cf-TS), T(SH)2 synthetase, TbTryS, TcTryS, TRS, trypanothione synthase, Trypanothione synthetase, Trypanothione synthetase (Crithidia fasciculata strain HS6 gene Cf-TS), trypanothione synthetase-amidase, TryS, TSA, TSH synthetase, tyrS

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

                6.3.1.9 trypanothione synthase

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Results	in table
15	Activating Compound
47	AA Sequence
8	Application
2	CAS Registry Number
16	Cloned(Commentary)
13	Cofactor
2	Crystallization (Commentary)
3	Expression
29	General Information
1	General Stability
104	IC50 Value
174	Inhibitors
16	Ki Value [mM]
41	KM Value [mM]
5	Localization
18	Metals/Ions
9	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
37	Organism
6	Pathway
5	PDB ID
13	pH Optimum
3	pH Range
17	Protein Variants
16	Purification (Commentary)
5	Reaction
1	Reaction Type
36	Reference
18	Source Tissue
5	Specific Activity [micromol/min/mg]
83	Substrates and Products (Substrate)
11	Subunits
68	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
13	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.1.9 - trypanothione synthase

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SYSTEMATIC NAME

IUBMB Comments

spermidine/glutathionylspermidine:glutathione ligase (ADP-forming)

The enzyme, characterized from several trypanosomatids (e.g. Trypanosoma cruzi) catalyses two subsequent reactions, leading to production of trypanothione from glutathione and spermidine. Some trypanosomatids (e.g. Crithidia species and some Leishmania species) also contain an enzyme that only carries out the first reaction (cf. EC 6.3.1.8, glutathionylspermidine synthase). The enzyme is bifunctional, and also catalyses the hydrolysis of glutathionylspermidine and trypanothione (cf. EC 3.5.1.78, glutathionylspermidine amidase).