6.3.1.9: trypanothione synthase
This is an abbreviated version!
For detailed information about trypanothione synthase, go to the full flat file.
Word Map on EC 6.3.1.9
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6.3.1.9
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trypanosoma
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leishmania
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trypanosomatids
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brucei
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cruzi
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fasciculata
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crithidia
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n1,n8-bisglutathionylspermidine
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chagas
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infantum
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tryparedoxine
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antileishmanial
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parasite-specific
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kinetoplastida
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antitrypanosomal
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drug development
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synthesis
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pharmacology
- 6.3.1.9
- trypanosoma
- leishmania
-
trypanosomatids
- brucei
- cruzi
- fasciculata
- crithidia
-
n1,n8-bisglutathionylspermidine
-
chagas
- infantum
-
tryparedoxine
-
antileishmanial
-
parasite-specific
- kinetoplastida
-
antitrypanosomal
- drug development
- synthesis
- pharmacology
Reaction
Synonyms
Cf-TS, GenBank AF006615-derived protein GI 3004644, LdTryS, LiTRYS, Synthetase, trypanothione, Synthetase, trypanothione (Crithidia fasciculata strain HS6 gene Cf-TS), T(SH)2 synthetase, TbTryS, TcTryS, TRS, trypanothione synthase, Trypanothione synthetase, Trypanothione synthetase (Crithidia fasciculata strain HS6 gene Cf-TS), trypanothione synthetase-amidase, TryS, TSA, TSH synthetase, tyrS
ECTree
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Reaction
Reaction on EC 6.3.1.9 - trypanothione synthase
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glutathione + glutathionylspermidine + ATP = N1,N8-bis(glutathionyl)spermidine + ADP + phosphate
the reaction is catalyzed by trypanothione synthase, which also catalyzes the reaction of glutathionyspermidine synthase, EC 6.3.1.8, in Crithidia fasciculata, trypanothione synthase further exhibits amidase and marginal ATPase activities
glutathione + glutathionylspermidine + ATP = N1,N8-bis(glutathionyl)spermidine + ADP + phosphate
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glutathione + glutathionylspermidine + ATP = N1,N8-bis-(glutathionyl)spermidine + ADP + phosphate
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glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate
ter-reactant mechanism of TryS catalysis, modeling, overview
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glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate
ter-reactant mechanism of TryS catalysis, modeling, overview
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