6.3.1.9: trypanothione synthase
This is an abbreviated version!
For detailed information about trypanothione synthase, go to the full flat file.
Word Map on EC 6.3.1.9
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6.3.1.9
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trypanosoma
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leishmania
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trypanosomatids
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brucei
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cruzi
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fasciculata
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crithidia
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n1,n8-bisglutathionylspermidine
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chagas
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infantum
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tryparedoxine
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antileishmanial
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parasite-specific
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kinetoplastida
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antitrypanosomal
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drug development
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synthesis
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pharmacology
- 6.3.1.9
- trypanosoma
- leishmania
-
trypanosomatids
- brucei
- cruzi
- fasciculata
- crithidia
-
n1,n8-bisglutathionylspermidine
-
chagas
- infantum
-
tryparedoxine
-
antileishmanial
-
parasite-specific
- kinetoplastida
-
antitrypanosomal
- drug development
- synthesis
- pharmacology
Reaction
Synonyms
Cf-TS, GenBank AF006615-derived protein GI 3004644, LdTryS, LiTRYS, Synthetase, trypanothione, Synthetase, trypanothione (Crithidia fasciculata strain HS6 gene Cf-TS), T(SH)2 synthetase, TbTryS, TcTryS, TRS, trypanothione synthase, Trypanothione synthetase, Trypanothione synthetase (Crithidia fasciculata strain HS6 gene Cf-TS), trypanothione synthetase-amidase, TryS, TSA, TSH synthetase, tyrS
ECTree
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KM Value
KM Value on EC 6.3.1.9 - trypanothione synthase
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0.19
GSH
pH 8.0, with N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine
0.0066
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recombinant enzyme, pH 8.0, 25°C, HEPES buffer, with spermidine
0.01
ATP
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recombinant enzyme, pH 8.0, 37°C, HEPES buffer, with spermidine
0.012
ATP
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recombinant enzyme, pH 7.0, 37°C, phosphate buffer, with glutathionylspermidine
0.018
ATP
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recombinant enzyme, pH 7.0, 37°C, phosphate buffer, with spermidine
0.032
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recombinant enzyme, pH 8.0, 25°C, HEPES buffer, with spermidine
0.034
glutathione
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recombinant enzyme, pH 7.0, 37°C, phosphate buffer, with glutathionylspermidine
0.045
glutathione
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recombinant enzyme, pH 8.0, 37°C, HEPES buffer, with spermidine
0.069
glutathione
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recombinant enzyme, pH 7.0, 37°C, phosphate buffer, with spermidine
0.407
glutathione
pH 7.2, 25°C, recombinant trypanothione synthase
0.04
pH 7.7, 25°C, recombinant trypanothione synthase
0.48
glutathionylspermidine
pH 7.2, 25°C, recombinant trypanothione synthase
0.012
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recombinant enzyme, pH 8.0, 25°C, HEPES buffer
0.016
N1-glutathionylspermidine
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recombinant enzyme, pH 8.0, 37°C, HEPES buffer
0.032
N1-glutathionylspermidine
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recombinant enzyme, pH 7.0, 37°C, phosphate buffer
0.012
N8-glutathionylspermidine
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recombinant enzyme, pH 8.0, 25°C, HEPES buffer
0.016
N8-glutathionylspermidine
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recombinant enzyme, pH 8.0, 37°C, HEPES buffer
0.032
N8-glutathionylspermidine
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recombinant enzyme, pH 7.0, 37°C, phosphate buffer
additional information
hyperbolic kinetics, steady-state kinetics
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additional information
additional information
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hyperbolic kinetics, steady-state kinetics
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additional information
additional information
steady-state kinetics for the multiple enzyme activities, Dalziel equation, overview
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additional information
additional information
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steady-state kinetics for the multiple enzyme activities, Dalziel equation, overview
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additional information
additional information
Michaelis-Menten steady-state kinetics
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additional information
additional information
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Michaelis-Menten steady-state kinetics
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additional information
additional information
Michaelis-Menten steady-state kinetics
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additional information
additional information
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Michaelis-Menten steady-state kinetics
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additional information
additional information
Michaelis-Menten steady-state kinetics
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additional information
additional information
Michaelis-Menten kinetics, simple hyperbolic kinetics with fixed glutathione concentration and with other substrates limiting Km values for Mg2+
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additional information
additional information
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Michaelis-Menten kinetics, simple hyperbolic kinetics with fixed glutathione concentration and with other substrates limiting Km values for Mg2+
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