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6.3.1.9: trypanothione synthase

This is an abbreviated version!
For detailed information about trypanothione synthase, go to the full flat file.

Word Map on EC 6.3.1.9

Reaction

glutathione
+
glutathionylspermidine
+
ATP
=
N1,N8-bis(glutathionyl)spermidine
+
ADP
+
phosphate

Synonyms

Cf-TS, GenBank AF006615-derived protein GI 3004644, LdTryS, LiTRYS, Synthetase, trypanothione, Synthetase, trypanothione (Crithidia fasciculata strain HS6 gene Cf-TS), T(SH)2 synthetase, TbTryS, TcTryS, TRS, trypanothione synthase, Trypanothione synthetase, Trypanothione synthetase (Crithidia fasciculata strain HS6 gene Cf-TS), trypanothione synthetase-amidase, TryS, TSA, TSH synthetase, tyrS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.9 trypanothione synthase

KM Value

KM Value on EC 6.3.1.9 - trypanothione synthase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0066 - 0.053
ATP
0.914
gamma-L-Glu-L-Cys-Gly
-
-
0.032 - 0.407
glutathione
0.04 - 0.48
glutathionylspermidine
0.19
GSH
pH 8.0, with N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine
0.063 - 0.4
MgATP2-
0.066
N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine
pH 8.0
0.012 - 0.032
N1-glutathionylspermidine
0.007 - 0.032
N8-glutathionylspermidine
0.092 - 1.07
spermidine
additional information
additional information
-