Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

6.3.1.1: aspartate-ammonia ligase

This is an abbreviated version!
For detailed information about aspartate-ammonia ligase, go to the full flat file.

Word Map on EC 6.3.1.1

Reaction

ATP
+
L-aspartate
 +
NH3
=
AMP
 +
diphosphate
 +
L-asparagine

Synonyms

ammonia-dependent ASNS, ammonia-dependent asparagine synthetase, AS-A, AS-AR, AsnA, ASNS, Asparagine synthetase, Asparagine synthetase A, asparagine synthetase, ammonia-dependent, L-Asparagine synthetase, NH4+-dependent asparagine synthetase, Synthetase, asparagine, Tb927.6.1880, TbASNA

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.1 aspartate-ammonia ligase

Inhibitors

Inhibitors on EC 6.3.1.1 - aspartate-ammonia ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
adenylated sulfoximine
-
-
diphosphate
-
-
iodoacetamide
-
-
L-Asp
N-ethylmaleimide
-
-
p-mercuribenzoate
-
-
sulfoximine
-
poor inhibitor
additional information
-
CHOP suppresses the induction of the endogenous ASNS gene and inhibits transcription from a reporter gene driven by the ASNS promoter following activation by ATF4 or amino acid deprivation. The inhibitory effect of CHOP on the ASNS gene is not observed when truncated proteins, encoding either the N- or C-terminal portion of the protein, are expressed, overview
-