6.2.1.20: long-chain-fatty-acid-[acyl-carrier-protein] ligase
This is an abbreviated version!
For detailed information about long-chain-fatty-acid-[acyl-carrier-protein] ligase, go to the full flat file.
Word Map on EC 6.2.1.20
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6.2.1.20
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harveyi
-
4'-phosphopantetheine
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holo-acp
-
4'-phosphopantetheinylated
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pptases
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lignoceric
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lignoceroyl-coa
-
synthesis
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biofuel production
- 6.2.1.20
- harveyi
- 4'-phosphopantetheine
-
holo-acp
-
4'-phosphopantetheinylated
- pptases
-
lignoceric
- lignoceroyl-coa
- synthesis
- biofuel production
Reaction
Synonyms
AAE15, AAS, AasC, AasS, ACP synthase, AcpS, ACSL, acyl carrier protein synthase, acyl-ACP synthase, Acyl-ACP synthetase, Acyl-acyl carrier protein synthetase, Acyl-CoA ligase, Acyl-CoA synthetase, Acyl-[acyl carrier protein] synthetase, Acyl-[acyl-carrier-protein]synthetase, At4g14070, CT776, CTO_0846, LipA, PfACP, slr1609, Stearoyl-ACP synthetase, Synthetase, acyl-[acyl carrier protein]
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Substrates Products
Substrates Products on EC 6.2.1.20 - long-chain-fatty-acid-[acyl-carrier-protein] ligase
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REACTION DIAGRAM
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
ATP + an acid + [acyl-carrier protein]
?
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enzyme functions in the incorporation of fatty acids into phospholipid
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-
?
ATP + cis-vaccenic acid + [acyl-carrier protein]
AMP + diphosphate + cis-vaccenoyl-[acyl-carrier protein]
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-
-
-
?
ATP + decanoate + an [acyl-carrier protein]
AMP + diphosphate + long-chain decanoyl-[acyl-carrier protein]
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-
-
?
ATP + decanoic acid + [acyl-carrier protein]
AMP + diphosphate + decanoyl-[acyl-carrier protein]
ATP + hexadecanoate + an [acyl-carrier protein]
AMP + diphosphate + hexadecanoyl-[acyl-carrier protein]
low activity
-
-
?
ATP + hexanoic acid + [acyl-carrier protein]
AMP + diphosphate + hexanoyl-[acyl-carrier protein]
ATP + laurate + an [acyl-carrier protein]
AMP + diphosphate + lauroyl-[acyl-carrier protein]
-
-
-
?
ATP + lauric acid + [acyl-carrier protein]
AMP + diphosphate + lauroyl-[acyl-carrier protein]
ATP + linoleic acid + [acyl-carrier protein]
AMP + diphosphate + linoleoyl-[acyl-carrier protein]
ATP + myristate + an [acyl-carrier protein]
AMP + diphosphate + myristoyl-[acyl-carrier protein]
-
-
-
?
ATP + myristic acid + [acyl-carrier protein]
AMP + diphosphate + myristoyl-[acyl-carrier protein]
ATP + octanoate + an [acyl-carrier protein]
AMP + diphosphate + octanoyl-[acyl-carrier protein]
low activity
-
-
?
ATP + octanoate + [AcpP1]
AMP + diphosphate + octanoyl-[AcpP1]
recombinant holo-AcpP1 from Pseudomonas aeruginosa
-
-
?
ATP + octanoate + [AcpP2]
AMP + diphosphate + octanoyl-[AcpP2]
recombinant holo-AcpP2 from Pseudomonas aeruginosa
-
-
?
ATP + octanoate + [AcpP3]
AMP + diphosphate + octanoyl-[AcpP3]
recombinant holo-AcpP3 from Pseudomonas aeruginosa
-
-
?
ATP + octanoate + [acyl-carrier protein]
AMP + diphosphate + octanoyl-[acyl-carrier protein]
ATP + octanoic acid + [acyl-carrier protein]
AMP + diphosphate + octanoyl-[acyl-carrier protein]
ATP + oleate + an [acyl-carrier protein]
AMP + diphosphate + oleoyl-[acyl-carrier protein]
ATP + oleic acid + [acyl-carrier protein]
AMP + diphosphate + oleoyl-[acyl-carrier protein]
ATP + palmitate + an [acyl-carrier protein]
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
ATP + palmitic acid + [acyl-carrier protein]
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
ATP + palmitoleic acid + [acyl-carrier protein]
AMP + diphosphate + palmitoleoyl-[acyl-carrier protein]
ATP + stearic acid + [acyl-carrier protein]
AMP + diphosphate + stearoyl-[acyl-carrier protein]
ATP + tetradecanoate + [acyl-carrier protein]
AMP + diphosphate + tetradecanoyl-[acyl-carrier protein]
dATP + a fatty acid + [acyl-carrier protein]
dAMP + diphosphate + fatty acid-[acyl-carrier protein]
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25% of the activity relative to ATP
-
-
?
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
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-
-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
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-
-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
-
-
-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
the enzyme uses host cell fatty acids as substrates
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-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
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the enzyme uses host cell fatty acids as substrates
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-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
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-
-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
the enzyme uses host cell fatty acids as substrates
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-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
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-
-
-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
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-
-
-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
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-
-
-
?
ATP + a long-chain fatty acid + an [acyl-carrier protein]
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]
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-
-
?
AMP + diphosphate + a long-chain acyl-LipD
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-
-
?
ATP + a long-chain fatty acid + LipD
AMP + diphosphate + a long-chain acyl-LipD
LipD structure analysis and comparisons, overview
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-
?
AMP + diphosphate + acyl-[acyl-carrier protein]
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E. coli enzyme is able to acylate acyl-carrier protein from spinach, soybean, avocado, corn, and several other plants
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-
?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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the best substrates are saturated fatty acids, C12:0 to C16:0
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?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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synthesis of activated acyl-carrier protein that is essential as a carrier of acyl-intermediates, donor for activated acyl groups for the synthesis of lipids and lipid derivatives, functions as 2-acylglycerophosphoethanolamine acyltransferase
-
-
?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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fatty acids with chain lengths between 8 and 18 carbons serve as substrates
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-
?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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-
-
-
?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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synthesis of activated acyl-carrier protein that is essential as a carrier of acyl-intermediates and donor for activated acyl groups for the synthesis of lipids and lipid derivatives
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-
?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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-
-
?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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synthesis of activated acyl-carrier protein that is essential as a carrier of acyl-intermediates and donor for activated acyl groups for the synthesis of lipids and lipid derivatives
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-
?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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mutations E41D, E41K, A45G, A45C, A45W and V43I in acyl-carrier protein have only minor effects on activity
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-
?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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mutations in acyl-carrier protein F50A, I54L and I54V increases Km-values, minor effects with mutations at positions V12G, Y71A and A59G
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-
?
ATP + an acid + [acyl-carrier protein]
AMP + diphosphate + acyl-[acyl-carrier protein]
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-
-
?
AMP + diphosphate + decanoyl-[acyl-carrier protein]
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-
-
-
?
ATP + decanoic acid + [acyl-carrier protein]
AMP + diphosphate + decanoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + decanoic acid + [acyl-carrier protein]
AMP + diphosphate + decanoyl-[acyl-carrier protein]
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-
-
-
?
AMP + diphosphate + hexanoyl-[acyl-carrier protein]
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-
-
-
?
ATP + hexanoic acid + [acyl-carrier protein]
AMP + diphosphate + hexanoyl-[acyl-carrier protein]
-
-
-
-
?
AMP + diphosphate + lauroyl-[acyl-carrier protein]
-
-
-
-
?
ATP + lauric acid + [acyl-carrier protein]
AMP + diphosphate + lauroyl-[acyl-carrier protein]
-
-
-
-
?
ATP + lauric acid + [acyl-carrier protein]
AMP + diphosphate + lauroyl-[acyl-carrier protein]
-
-
-
-
?
AMP + diphosphate + linoleoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + linoleic acid + [acyl-carrier protein]
AMP + diphosphate + linoleoyl-[acyl-carrier protein]
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most effective subtrate
-
-
?
AMP + diphosphate + myristoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + myristic acid + [acyl-carrier protein]
AMP + diphosphate + myristoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + myristic acid + [acyl-carrier protein]
AMP + diphosphate + myristoyl-[acyl-carrier protein]
-
-
-
-
?
AMP + diphosphate + octanoyl-[acyl-carrier protein]
acyl-carrier protein from Eschrichia coli is a good substrate, whilst octanoylation of the Lactococcus lactis acyl-carrier protein is very weak and that of the bovine mitochondrial acyl-carrier protein only barely detectable
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-
?
ATP + octanoate + [acyl-carrier protein]
AMP + diphosphate + octanoyl-[acyl-carrier protein]
acyl-carrier protein from Eschrichia coli is a good substrate, whilst octanoylation of the Lactococcus lactis acyl-carrier protein is very weak and that of the bovine mitochondrial acyl-carrier protein only barely detectable
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-
?
AMP + diphosphate + octanoyl-[acyl-carrier protein]
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-
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-
?
ATP + octanoic acid + [acyl-carrier protein]
AMP + diphosphate + octanoyl-[acyl-carrier protein]
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-
-
-
?
ATP + octanoic acid + [acyl-carrier protein]
AMP + diphosphate + octanoyl-[acyl-carrier protein]
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-
-
-
?
AMP + diphosphate + oleoyl-[acyl-carrier protein]
-
-
-
?
ATP + oleate + an [acyl-carrier protein]
AMP + diphosphate + oleoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + oleate + an [acyl-carrier protein]
AMP + diphosphate + oleoyl-[acyl-carrier protein]
-
-
-
?
AMP + diphosphate + oleoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + oleic acid + [acyl-carrier protein]
AMP + diphosphate + oleoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + oleic acid + [acyl-carrier protein]
AMP + diphosphate + oleoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + oleic acid + [acyl-carrier protein]
AMP + diphosphate + oleoyl-[acyl-carrier protein]
-
-
-
?
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
preferred acyl substrate
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-
?
ATP + palmitate + an [acyl-carrier protein]
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
-
preferred acyl substrate
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-
?
ATP + palmitate + an [acyl-carrier protein]
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
preferred acyl substrate
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-
?
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + palmitic acid + [acyl-carrier protein]
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
-
-
-
?
ATP + palmitic acid + [acyl-carrier protein]
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + palmitic acid + [acyl-carrier protein]
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
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-
-
?
ATP + palmitic acid + [acyl-carrier protein]
AMP + diphosphate + palmitoyl-[acyl-carrier protein]
-
-
-
-
?
AMP + diphosphate + palmitoleoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + palmitoleic acid + [acyl-carrier protein]
AMP + diphosphate + palmitoleoyl-[acyl-carrier protein]
-
-
-
-
?
AMP + diphosphate + stearoyl-[acyl-carrier protein]
-
stearic acid is a better substrate than palmitic acid or oleic acid
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-
?
ATP + stearic acid + [acyl-carrier protein]
AMP + diphosphate + stearoyl-[acyl-carrier protein]
-
-
-
-
?
ATP + stearic acid + [acyl-carrier protein]
AMP + diphosphate + stearoyl-[acyl-carrier protein]
-
-
-
-
?
AMP + diphosphate + tetradecanoyl-[acyl-carrier protein]
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-
-
?
ATP + tetradecanoate + [acyl-carrier protein]
AMP + diphosphate + tetradecanoyl-[acyl-carrier protein]
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-
-
?
?
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different surface charges of acyl-carrier protein derivatives LipD and FAS-ACP from Actinoplanes friuliensis allow the acyl-CoA ligase to interact preferentially with the LipD instead of binding to the FAS-ACP, overview
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-
?
additional information
?
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recombinant enzyme AAE15 has acyl-ACP synthetase activity in vitro with specificity for medium chain fatty acids, substrate specificity, overview. Low activity with fatty acids 18:0, 18:1, 18:2, and 18:3
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?
additional information
?
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exogenous fatty acids are elongated and incorporated into phospholipids by Escherichia coli-expressing AasC, illustrating its function as an acyl-ACP synthetase in vivo
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?
additional information
?
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exogenous fatty acids are elongated and incorporated into phospholipids by Escherichia coli-expressing AasC, illustrating its function as an acyl-ACP synthetase in vivo
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?
additional information
?
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exogenous fatty acids are elongated and incorporated into phospholipids by Escherichia coli-expressing AasC, illustrating its function as an acyl-ACP synthetase in vivo
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?
additional information
?
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exogenous fatty acids are elongated and incorporated into phospholipids by Escherichia coli-expressing AasC, illustrating its function as an acyl-ACP synthetase in vivo
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?
additional information
?
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enzyme may function to reintroduce free fatty acids into the biosynthetic pathway
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?
additional information
?
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possibly functions in the activation of free fatty acids into a form that can be transferred into phospholipid
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?
additional information
?
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physiological role of 2-acylglycerophosphoethanolamine acyltransferase/acyl-acyl carrier protein synthetase in fatty acid uptake and lysophospholipid uptake, and in maintaining membrane phospholipid composition
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?
additional information
?
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the cell-free extract of Pseudomonas aeruginosa can acylate only the holo-form of the acyl carrier protein AcpP1 for the synthesis of fatty acids, while it is inactive with acyl carrier proteins AcpP2 and AcpP3
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?
additional information
?
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rather broad substrate specificity, accepting fatty acids with chain length between C12 and C18
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?
additional information
?
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rather broad substrate specificity, accepting fatty acids with chain length between C12 and C18
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?
additional information
?
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the enzyme from Vibrio harveyi can acylate holo-forms of the acyl carrier proteins, AcpP1, AcpP2, and AcpP3, from Pseudomonas aeruginosa
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?