6.2.1.2: medium-chain acyl-CoA ligase

This is an abbreviated version!
For detailed information about medium-chain acyl-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.2

6.2.1.2

desaturase

polyunsaturated

pufas

docosahexaenoic

arachidonic

monounsaturated

eicosapentaenoic

linoleic

desaturation

elovl5

unsaturated

lc-pufas

acyl-coas

oleic

stearoyl-coa

very-long-chain

vlcfas

palmitoleic

delta6

stearic

alpha-linolenic

linseed

gamma-linolenic

alpina

stargardt

mortierella

isochrysis

3-ketoacyl-coa

erucic

cis-vaccenic

vaccenic

dihomo-gamma-linolenic

medicine

stearidonic

Reaction

Synonyms

Acyl-activating enzyme, butanoate:CoA ligase (AMP-forming), butyrate-CoA ligase, Butyryl-CoA synthetase, Butyryl-coenzyme A synthetase, EloA, elongase, Fatty acid thiokinase (medium chain), L-(+)-3-Hydroxybutyryl CoA ligase, Macs, MACS2, medium chain acyl-CoA synthase, medium chain acyl-CoA synthetase, Medium chain acyl-coenzyme A synthetase, medium-chain acyl coenzyme A synthetase, medium-chain acyl-CoA synthetase 2, Mig protein, More, Short-chain acyl-CoA synthetase, Synthetase, butyryl conzyme A, xenobiotic/medium-chain fatty acid:CoA ligase, XM-ligase

ECTree

6 Ligases

6.2 Forming carbon-sulfur bonds

6.2.1 Acid-thiol ligases

6.2.1.2 medium-chain acyl-CoA ligase

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Results	in table
4	Activating Compound
165	AA Sequence
1	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
105	Disease/ Diagnostics
1	General Stability
1	IC50 Value
57	Inhibitors
3	kcat/KM [mM/s]
13	Ki Value [mM]
39	KM Value [mM]
16	Localization
15	Metals/Ions
15	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
33	Organism
14	Pathway
13	PDB ID
9	pH Optimum
2	pH Range
1	pH Stability
6	Protein Variants
17	Purification (Commentary)
3	Reaction
1	Reaction Type
32	Reference
32	Source Tissue
10	Specific Activity [micromol/min/mg]
1	Storage Stability
154	Substrates and Products (Substrate)
11	Subunits
30	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

KM Value

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KM Value on EC 6.2.1.2 - medium-chain acyl-CoA ligase

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8.92

2-methylbutyrate

Methanosarcina acetivorans

Q8TLW1

pH 7.5, 55°C

727750

0.036 - 4.21

ATP

7 entries

0.007

benzoate

Bos taurus

649709

0.14 - 4.2

Butyrate

4 entries

0.02 - 4.09

CoA

9 entries

1.775

Decanoate

Mycobacterium avium

650334

0.02

dodecanoate

Mycobacterium avium

650334

1.6

Isobutyrate

Paecilomyces variotii

668

0.47

Isopentanoate

Paecilomyces variotii

668

L-(+)-3-hydroxybutyrate

Rattus norvegicus

670

0.97

MgATP2-

Pseudomonas aeruginosa

669

0.001

myristic acid

Penicillium chrysogenum

O74725

below, pH 8.5, 30°C, recombinant enzyme

690837

0.108 - 0.285

Octanoate

2 entries

0.38

pentanoate

Paecilomyces variotii

668

2.1

Phenoxyacetate

Penicillium chrysogenum

O74725

pH 8.5, 30°C, recombinant enzyme

690837

5.2 - 6.1

phenylacetate

Penicillium chrysogenum

O74725

pH 8.5, 30°C, recombinant enzyme

690837

3.3

propionate

Paecilomyces variotii

668

propionic acid

Penicillium chrysogenum

O74725

pH 8.5, 30°C, recombinant enzyme

690837

0.19

trans-cinnamic acid

Penicillium chrysogenum

O74725

pH 8.5, 30°C, recombinant enzyme

690837

additional information

2 entries