6.2.1.2: medium-chain acyl-CoA ligase

This is an abbreviated version!
For detailed information about medium-chain acyl-CoA ligase, go to the full flat file.

Reaction

Synonyms

Acyl-activating enzyme, butanoate:CoA ligase (AMP-forming), butyrate-CoA ligase, Butyryl-CoA synthetase, Butyryl-coenzyme A synthetase, EloA, elongase, Fatty acid thiokinase (medium chain), L-(+)-3-Hydroxybutyryl CoA ligase, Macs, MACS2, medium chain acyl-CoA synthase, medium chain acyl-CoA synthetase, Medium chain acyl-coenzyme A synthetase, medium-chain acyl coenzyme A synthetase, medium-chain acyl-CoA synthetase 2, Mig protein, More, Short-chain acyl-CoA synthetase, Synthetase, butyryl conzyme A, xenobiotic/medium-chain fatty acid:CoA ligase, XM-ligase

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.2 medium-chain acyl-CoA ligase

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Results	in table
4	Activating Compound
165	AA Sequence
1	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
105	Disease/ Diagnostics
1	General Stability
1	IC50 Value
57	Inhibitors
3	kcat/KM [mM/s]
13	Ki Value [mM]
39	KM Value [mM]
16	Localization
15	Metals/Ions
15	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
33	Organism
14	Pathway
13	PDB ID
9	pH Optimum
2	pH Range
1	pH Stability
6	Protein Variants
17	Purification (Commentary)
3	Reaction
1	Reaction Type
32	Reference
32	Source Tissue
10	Specific Activity [micromol/min/mg]
1	Storage Stability
154	Substrates and Products (Substrate)
11	Subunits
30	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 6.2.1.2 - medium-chain acyl-CoA ligase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

(NH4)2SO4

Bos taurus

-

-

677

2-hydroxydodecanoic acid

4 entries

2-Hydroxynaphthoic acid

2 entries

2-Hydroxyoctanoic acid

Bos taurus

-

competitive with respect to hexanoate

682

2-hydroxyphenylacetic acid

Bos taurus

-

-

649783

4-methylsalicylic acid

Bos taurus

-

competitive with respect to hexanoate

682

5,5'-dithiobis(2-nitrobenzoate)

Bos taurus

-

-

672

AgNO3

Pseudomonas aeruginosa

-

-

669

AMP

2 entries

benzoate

Bos taurus

-

competitive inhibitor of butyrate

649709

benzoyl-CoA

Bos taurus

-

product inhibitor

649709

Butyrate

Bos taurus

-

competitive inhibitor of benzoate

649709

butyryl-CoA

2 entries

cyclohexane carboxylate

Sus scrofa

-

-

650950

diflunisal

5 entries

diphosphate

2 entries

dithiothreitol

Rattus norvegicus

-

-

658

enoxacin

3 entries

felbinac

Mus musculus

-

inhibits activity with hexanoic acid, IC50: 0.025 mM

649791

GSH

Rattus norvegicus

-

-

658

Hg(CH3COO)2

Pseudomonas aeruginosa

-

-

669

HgCl2

Pseudomonas aeruginosa

-

-

669

iodoacetamide

Bos taurus

-

-

672, 678

mercury compounds

Pseudomonas aeruginosa

-

-

669

-

Nalidixic acid

4 entries

Octanoate

Rattus norvegicus

-

valproyl-AMP synthesis

681

ofloxacin

Mus musculus

-

potent, mixed-type inhibition

649791

ofloxacine

2 entries

p-chloromercuribenzoate

3 entries

salicylic acid

6 entries

silver compounds

Pseudomonas aeruginosa

-

-

669

-

sulfhydryl reagents

Bos taurus

-

-

672

2-hydroxydodecanoic acid

Bos taurus

-

-

649783

2-hydroxydodecanoic acid

Mus musculus

-

competitive; potent

649791

2-hydroxydodecanoic acid

Mus musculus

-

0.04 mM, 48% inhibition

650831

2-hydroxydodecanoic acid

Mycobacterium avium

-

-

650334

2-Hydroxynaphthoic acid

Bos taurus

-

competitive with respect to hexanoate

682

2-Hydroxynaphthoic acid

Mus musculus

-

competitive; potent

649791

AMP

Bos taurus

-

product inhibitor

649709

AMP

Paecilomyces variotii

-

competitive for ATP

668

butyryl-CoA

Bos taurus

-

competitive inhibitor with respect to both butyrate and benzoate

649709

butyryl-CoA

Paecilomyces variotii

-

competitive for ATP

668

diflunisal

Bos taurus

-

competitive

649783

diflunisal

Bos taurus

-

0.001 mM, complete inhibition

676959

diflunisal

Mus musculus

-

competitive; potent

649791

diflunisal

Mus musculus

-

0.002 mM, 55% inhibition

650831

diflunisal

Mus musculus

-

0.001 mM, complete inhibition

676959

diphosphate

Bos taurus

-

weak product inhibitor, competitive with respect to CoA and mixed inhibitor with respect to benzoate. Mixed type inhibitor with respect to CoA in butyrate:CoA ligase activity

649709

diphosphate

Paecilomyces variotii

-

competitive for CoA

668

enoxacin

Bos taurus

-

-

676959

enoxacin

Mus musculus

-

potent, mixed-type inhibition

649791

enoxacin

Mus musculus

-

-

676959

Nalidixic acid

Bos taurus

-

competitive

649783

Nalidixic acid

Bos taurus

-

0.001 mM, complete inhibition

676959

Nalidixic acid

Mus musculus

-

competitive; potent

649791

Nalidixic acid

Mus musculus

-

0.001 mM, complete inhibition

676959

ofloxacine

Bos taurus

-

-

676959

ofloxacine

Mus musculus

-

-

676959

p-chloromercuribenzoate

Bos taurus

-

-

672

p-chloromercuribenzoate

Bos taurus

-

butyrate or ATP partially protects

677

p-chloromercuribenzoate

Pseudomonas aeruginosa

-

-

669

salicylic acid

Bos taurus

-

0.001 mM, complete inhibition

676959

salicylic acid

Bos taurus

-

-

678

salicylic acid

Bos taurus

-

competitive with respect to hexanoate

682

salicylic acid

Mus musculus

-

competitive; potent

649791

salicylic acid

Mus musculus

-

0.05 mM, 53% inhibition

650831

salicylic acid

Mus musculus

-

0.001 mM, complete inhibition

676959