6.2.1.19: long-chain-fatty-acid-protein ligase

This is an abbreviated version!
For detailed information about long-chain-fatty-acid-protein ligase, go to the full flat file.

Word Map on EC 6.2.1.19

Reaction

ATP
+
a long-chain fatty acid
+
[protein]-L-cysteine
=
AMP
+
diphosphate
+
a [protein]-S-(long-chain-acyl)-L-cysteine

Synonyms

Acyl-protein synthetase, synthetase, acyl protein, Acyl protein synthetase, long-chain-fatty-acid-luciferin-component ligase

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.19 long-chain-fatty-acid-protein ligase

Systematic Name

Systematic Name on EC 6.2.1.19 - long-chain-fatty-acid-protein ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SYSTEMATIC NAME
IUBMB Comments
long-chain-fatty-acid:protein ligase (AMP-forming)
Together with a hydrolase component (EC 3.1.2.2/EC 3.1.2.14) and a reductase component (EC 1.2.1.50), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme activates free long-chain fatty acids, generated by the action of the transferase component, forming a fatty acyl-AMP intermediate, followed by the transfer of the acyl group to an internal L-cysteine residue. It then transfers the acyl group to EC 1.2.1.50, long-chain acyl-protein thioester reductase.