6.2.1.17: propionate-CoA ligase

This is an abbreviated version!
For detailed information about propionate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.17

6.2.1.17

acetyl-coa

propionylation

3-hydroxypropionate

chloroflexus

acryloyl-coa

butyryl-coa

methylcitrate

metallosphaera

sedula

aurantiacus

synthesis

analysis

Reaction

Synonyms

3-hydroxypropionyl-CoA synthetase, 3-hydroxypropionyl-coenzyme A synthetase, ACSS3, Propionate-CoA synthetase, Propionyl CoA synthetase, Propionyl-CoA synthase, Propionyl-CoA synthetase, Propionyl-coenzyme A synthetase, PrpE, Synthetase, propionyl coenzyme A

ECTree

6 Ligases

6.2 Forming carbon-sulfur bonds

6.2.1 Acid-thiol ligases

6.2.1.17 propionate-CoA ligase

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Results	in table
1	Activating Compound
6621	AA Sequence
2	Application
2	CAS Registry Number
13	Cloned(Commentary)
8	Cofactor
1	Expression
1	General Stability
13	Inhibitors
1	Ki Value [mM]
62	KM Value [mM]
8	Localization
13	Metals/Ions
14	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
28	Organism
13	Pathway
10	pH Optimum
6	pH Stability
8	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
26	Reference
14	Source Tissue
14	Specific Activity [micromol/min/mg]
2	Storage Stability
98	Substrates and Products (Substrate)
11	Subunits
28	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
37	Turnover Number [1/s]

Engineering

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Engineering on EC 6.2.1.17 - propionate-CoA ligase

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Go to Protein Variants Search

G245A

58% of activity

G249A

11% of activity

K248A

12% of activity

K248E

6% of activity

K592A

complete loss of activity

654636

K592E

Salmonella enterica

complete loss of activity

654636

P247A

Salmonella enterica

activity almost not affected

654636

additional information

Salmonella enterica

coexpression of the enzyme from Salmonella enterica together with the polyhydroxyalkanoate synthesis operon phaBCA from Ralstonia eutropha in Escherichia coli to produce poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) of specified composition between 5% and 18% HV, Metabolic pathways for PHBV synthesis, overview

691426