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6.2.1.13: acetate-CoA ligase (ADP-forming)

This is an abbreviated version!
For detailed information about acetate-CoA ligase (ADP-forming), go to the full flat file.

Word Map on EC 6.2.1.13

Reaction

ATP
+
acetate
 +
CoA
=
ADP
 +
phosphate
 +
acetyl-CoA

Synonyms

ACD, acetate:CoA ligase [ADP-forming], acetate:coenzyme A ligase (ADP-forming), Acetyl-CoA synthetase, Acetyl-CoA synthetase (ADP-forming), acetyl-coenzyme A synthetase, acetyl-coenzyme A synthetase (ADP-forming), ACS, ACS III, ACS1, ACS2, ADP acetyl-coenzyme A synthetase, ADP-ACS, ADP-forming acetyl-CoA synthetase, ADP-forming acetyl-CoA synthetase isoenzyme I, ADP-forming acetyl-coenzyme A synthetase, ADP-forming acyl coenzyme A synthetase, ADP-forming acyl-CoA synthetase, EhACD, PF1540, PF1787, Synthetase, acetyl coenzyme A (adenosine diphosphate-forming), TK0944/TK0943 protein

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.13 acetate-CoA ligase (ADP-forming)

KCat KM Value

KCat KM Value on EC 6.2.1.13 - acetate-CoA ligase (ADP-forming)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.59 - 58
acetate
0.06 - 2600
acetyl-CoA
0.2 - 89
ADP
0.07 - 965
ATP
0.57 - 9490
CoA
90
GDP
with acetyl-CoA as cosubstrate, at pH 7.3 and 37°C
18
GTP
with acetate as cosubstrate, at pH 7.3 and 37°C
385
Isobutyrate
Q5JIA8; Q5JIA9
at pH 6.5 and 55°C
123
phenylacetate
Q5JIA8; Q5JIA9
at pH 6.5 and 55°C
0.97 - 95
phosphate
6.3
propionate
at pH 7.3 and 37°C
650
propionyl-CoA
at pH 7.3 and 37°C
81
thioglycolate
Q5JIA8; Q5JIA9
at pH 6.5 and 55°C