6.2.1.13: acetate-CoA ligase (ADP-forming)
This is an abbreviated version!
For detailed information about acetate-CoA ligase (ADP-forming), go to the full flat file.
Word Map on EC 6.2.1.13
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6.2.1.13
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archaea
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saethre-chotzen
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amitochondriate
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hyperthermophilic
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cranial
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protist
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entamoeba
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giardia
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histolytica
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acrocephalosyndactyly
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amp-forming
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pyrococcus
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furiosus
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succinyl-coa
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skull
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propionyl-coa
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lamblia
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pyruvate:ferredoxin
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sutures
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archaeoglobus
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archaebacteria
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phosphotransacetylase
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acetate-forming
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ppi-dependent
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syndactyly
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embden-meyerhof
- 6.2.1.13
- archaea
-
saethre-chotzen
-
amitochondriate
-
hyperthermophilic
-
cranial
-
protist
-
entamoeba
- giardia
- histolytica
-
acrocephalosyndactyly
-
amp-forming
- pyrococcus
- furiosus
- succinyl-coa
-
skull
- propionyl-coa
- lamblia
-
pyruvate:ferredoxin
-
sutures
- archaeoglobus
- archaebacteria
- phosphotransacetylase
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acetate-forming
-
ppi-dependent
-
syndactyly
-
embden-meyerhof
Reaction
Synonyms
ACD, acetate:CoA ligase [ADP-forming], acetate:coenzyme A ligase (ADP-forming), Acetyl-CoA synthetase, Acetyl-CoA synthetase (ADP-forming), acetyl-coenzyme A synthetase, acetyl-coenzyme A synthetase (ADP-forming), ACS, ACS III, ACS1, ACS2, ADP acetyl-coenzyme A synthetase, ADP-ACS, ADP-forming acetyl-CoA synthetase, ADP-forming acetyl-CoA synthetase isoenzyme I, ADP-forming acetyl-coenzyme A synthetase, ADP-forming acyl coenzyme A synthetase, ADP-forming acyl-CoA synthetase, EhACD, PF1540, PF1787, Synthetase, acetyl coenzyme A (adenosine diphosphate-forming), TK0944/TK0943 protein
ECTree
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General Information
General Information on EC 6.2.1.13 - acetate-CoA ligase (ADP-forming)
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evolution
the enzyme is a member of the NDP-forming acyl-CoA synthetase enzyme superfamily
malfunction
metabolism
physiological function
additional information
amoebae lacking enzyme activity are unable to reestablish the acetyl-CoA/CoA ratio after an oxidative stress challenge
malfunction
gradual ACS gene silencing (49-93%) significantly decreases the acetate flux without affecting the levels of glycolytic metabolites and ATP in trophozoites. Amoebae lacking ACS activity are unable to reestablish the acetyl-CoA/CoA ratio after an oxidative stress challenge
the enzyme is related to the phosphate-dependent fermentative glycolysis in Entamoeba histolytica. The end-products of carbohydrate catabolism in the parasite are ethanol and acetate, produced by the bifunctional aldehyde-alcohol dehydrogenase (ADHE) and ACS, respectively, overview
metabolism
the main role of the enzyme in the parasite energy metabolism is to recycle CoA for glycolysis to proceed under aerobic conditions
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growth arrest is caused by elevated Acs, EC 6.2.1.1, activity, while overproduction of ADP-forming Ac-CoA synthesizing systems do not affect the growth behaviour of acetylation-deficient or acetylation-proficient strains
physiological function
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Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming)
physiological function
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Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming)
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residue His252 is essential for enzymatic activity, substrate binding structure and mechanism, overview
additional information
residue His252 is essential for enzymatic activity, substrate binding structure and mechanism, overview