6.1.1.5: isoleucine-tRNA ligase

This is an abbreviated version!
For detailed information about isoleucine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.5

6.1.1.5

synthetases

aminoacyl-trna

aminoacylation

isoleucylation

valyl-trna

misactivated

methionyl-trna

leurs

mischarged

pseudomonic

post-transfer

noncognate

valrs

mupirocin-resistant

misacylated

anticodons

aarss

kmsks

glnrs

trna-dependent

pretransfer

lysyl-trna

molecular biology

medicine

drug development

Reaction

Synonyms

EcIleRS, IARS2, Ile-tRNA synthetase, IleRS, ileS, ileS1, ileS2, IRS, Isoleucine translase, Isoleucine--tRNA ligase, Isoleucine-transfer RNA ligase, Isoleucine-tRNA synthetase, isoleucyl tRNA synthetase, Isoleucyl-transfer ribonucleate synthetase, Isoleucyl-transfer RNA synthetase, Isoleucyl-tRNA synthetase, mitochondrial isoleucyl-tRNA synthetase, More, mt isoleucyl-tRNA synthetase, mt-IleRS, Mupirocin resistance protein, ScIleRS, SgIleRS, Synthetase, isoleucyl-transfer ribonucleate

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.5 isoleucine-tRNA ligase

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Results	in table
3	Activating Compound
55114	AA Sequence
4	Application
1	CAS Registry Number
18	Cloned(Commentary)
31	Cofactor
5	Crystallization (Commentary)
148	Disease/ Diagnostics
29	General Information
6	IC50 Value
130	Inhibitors
10	kcat/KM [mM/s]
21	Ki Value [mM]
41	KM Value [mM]
14	Localization
50	Metals/Ions
11	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
1171	Organism
4	Pathway
17	PDB ID
18	pH Optimum
1	pH Range
43	Protein Variants
17	Purification (Commentary)
8	Reaction
60	Reaction Type
91	Reference
10	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
137	Substrates and Products (Substrate)
15	Subunits
262	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
3	Temperature Stability [°C]
29	Turnover Number [1/s]

Purification

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Purification on EC 6.1.1.5 - isoleucine-tRNA ligase

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6 entries

native enzyme, and recombinant enzyme from Escherichia coli, amino acid sequence determination

Pseudomonas fluorescens

Q8L1B1

652415

partial

Thermus thermophilus

466

recombinant His-tagged IleRS from Escherichia coli strain BL21 (DE3) by nickel affinity chromatography

Escherichia coli

715519

recombinant His-tagged wild-type and mutant enzymes from Escherichia coli strain BL21(DE3) by nickel affinity chromatography

2 entries

recombinant His-tagged wild-type and mutant enzymes from Escherichia coli strain Rosetta (DE3) by nickel affinity chromatography and gel filtration in stable monomeric form

Saccharomyces cerevisiae

P09436

745362

recombinant His-tagged wild-type and mutants enzymes from Escherichia coli by nickel affinity chromatography

Thermus thermophilus

P56690

675388

recombinant N-terminally His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography

Streptococcus pneumoniae

using M2-FLAG resin