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6.1.1.5: isoleucine-tRNA ligase

This is an abbreviated version!
For detailed information about isoleucine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.5

Reaction

ATP
+
L-isoleucine
+
tRNAIle
=
AMP
+
diphosphate
+
L-isoleucyl-tRNAIle

Synonyms

EcIleRS, IARS2, Ile-tRNA synthetase, IleRS, ileS, ileS1, ileS2, IRS, Isoleucine translase, Isoleucine--tRNA ligase, Isoleucine-transfer RNA ligase, Isoleucine-tRNA synthetase, isoleucyl tRNA synthetase, Isoleucyl-transfer ribonucleate synthetase, Isoleucyl-transfer RNA synthetase, Isoleucyl-tRNA synthetase, mitochondrial isoleucyl-tRNA synthetase, More, mt isoleucyl-tRNA synthetase, mt-IleRS, Mupirocin resistance protein, ScIleRS, SgIleRS, Synthetase, isoleucyl-transfer ribonucleate

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.5 isoleucine-tRNA ligase

KI Value

KI Value on EC 6.1.1.5 - isoleucine-tRNA ligase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000027
9-(alpha-D-arabinofuranosyl)-9H-purin-6-amine
-
pH and temperature not specified in the publication
0.00004
ethyl monate-A
-
pH 7.9, 22°C
0.000003
Ile-NHSO2-AMP
-
pH 7.9, 22°C
0.00003
Ile-ol-AMP
-
pH 7.9, 22°C
0.00003
isoleucinol adenylate
-
pH 7.9, 22°C, in complex with the enzyme and Ile, in analogy to the reaction intermediate
0.00009
isoleucinyl-adenylate
-
pH 7.9, 22°C
0.00025 - 0.0023
muciproin
0.0000027
NSC70422
-
pH and temperature not specified in the publication
0.000001 - 0.00002
pseudomonic acid
0.000045
SB-205952
-
pH 7.9, 22°C
additional information
additional information
-