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6.1.1.22: asparagine-tRNA ligase

This is an abbreviated version!
For detailed information about asparagine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.22

Reaction

ATP
+
L-asparagine
 +
tRNAAsn
=
AMP
 +
diphosphate
 +
L-asparaginyl-tRNAAsn

Synonyms

AS-AR, AsnRS, Asparagine synthetase A, Asparagine translase, asparagine tRNA synthetase, Asparagine--tRNA ligase, Asparaginyl transfer ribonucleic acid synthetase, Asparaginyl transfer RNA synthetase, asparaginyl tRNA synthetase, Asparaginyl-transfer ribonucleate synthetase, asparaginyl-transfer RNA synthetase, Asparaginyl-tRNA synthetase, Asparagyl-transfer RNA synthetase, class IIb asparaginyl-tRNA synthetase, More, NARS, NARS2, NRS, Potentially protective 63 kDa antigen, PYRAB02460, Synthetase, asparaginyl-transfer ribonucleate

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.22 asparagine-tRNA ligase

Inhibitors

Inhibitors on EC 6.1.1.22 - asparagine-tRNA ligase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-cyanoalanine
-
aminoacylation of Asn, competitive
3D6
monoclonal antibody
-
5'-O-[N-(L-asparaginyl)sulfamoyl]adenosine
a non-hydrolysable analogue of asparaginyl adenylate, i.e. Asn-SA
adipostatin A
-
-
adipostatin B
-
-
adipostatin C
-
-
adipostatin D
-
-
Asn-S-adenylate
-
asparaginyl sulfamoyl adenylate
Aspartate 3-hydroxamate
-
Asn-dependent ATP-diphosphate exchange, competitive
Br-
-
1.2 M, 50% inhibition of ATP-diphosphate exchange
CH3COO-
-
1.3 M, 50% inhibition of ATP-diphosphate exchange
Cl-
-
2.5 M, 50% inhibition of ATP-diphosphate exchange
CNS-
-
0.4 M, 50% inhibition of ATP-diphosphate exchange
Cs+
-
1.3 M, 50% inhibition of ATP-diphosphate exchange
cycloadenosine
-
-
I-
-
0.5 M, 50% inhibition of ATP-diphosphate exchange
isoasparagine
-
aminoacylation of Asn, competitive
K+
-
2.5 M, 50% inhibition of ATP-diphosphate exchange
L-aspartate-beta-hydroxamate adenylate
-
i.e. LBHAMP
LCM01
LCM02
Li+
-
0.7 M, 50% inhibition of ATP-diphosphate exchange
Na+
-
2.0 M, 50% inhibition of ATP-diphosphate exchange
NH4+
-
0.9 M, 50% inhibition of ATP-diphosphate exchange
NO3-
-
1.0 M, 50% inhibition of ATP-diphosphate exchange
NSC114691
NSC12156
NSC35467
-
i.e. 2-(3-methyl-1 lambda5-pyridin-1-yl)-1-(2-phenanthryl)ethanone, 53% inhibition at 0.2 mM
NSC363624
p-chloromercuribenzoate
-
-
rishirilide B
S-methyl-deoxyvariolin B
-
i.e. SMEVAR
threo-3-Hydroxyasparagine
-
aminoacylation of Asn, competitive
tirandamycin A
-
selective inhibitor
tirandamycin B
-
selective inhibitor
tirandamycin E
-
selective inhibitor
tirandamycin F
-
selective inhibitor
tirandamycin G
-
selective inhibitor
Tris
-
above 0.3 M
variolin B
-
-
additional information
-
no inhibition by NSC35467 at 0.2 mM
-