6.1.1.21: histidine-tRNA ligase

This is an abbreviated version!
For detailed information about histidine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.21

Reaction

ATP
+
L-histidine
+
tRNAHis
=
AMP
+
diphosphate
+
L-histidyl-tRNAHis

Synonyms

Histidyl-tRNA synthetase, Synthetase, histidyl-transfer ribonucleate, Histidyl-transfer ribonucleate synthetase, Histidine translase, HisRS, Jo-1, Jo-1 antigen, Histidine--tRNA ligase, Histidine--tRNA ligase homolog, histidine-tRNA ligase homolog, histidine-tRNA ligase, HRS, histidyl-transfer RNA synthetase, antihistidyl-tRNA synthetase, histidyl tRNA synthetase, HTS1, class II histidyl-tRNA synthetase, HisRS-1, HisRS-2, mitochondrial histidyl tRNA synthetase, HARS1, HARS2, HARS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.21 histidine-tRNA ligase

Substrates Products

Substrates Products on EC 6.1.1.21 - histidine-tRNA ligase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-methyl-L-histidine + tRNAHis
AMP + diphosphate + 1-methyl-L-histidyl-tRNAHis
show the reaction diagram
-
-
-
-
?
ATP + 2-thio-L-histidine + tRNAHis
AMP + diphosphate + 2-thio-L-histidyl-tRNAHis
show the reaction diagram
-
low activity
-
-
?
ATP + 3-methyl-L-histidine + tRNAHis
AMP + diphosphate + 3-methyl-L-histidyl-tRNAHis
show the reaction diagram
-
-
-
-
?
ATP + D-histidine + tRNAHis
AMP + diphosphate + D-histidyl-tRNAHis
show the reaction diagram
-
-
-
-
?
ATP + L-histidine + minimalist RNA structures in a resected pseudoknot fold
AMP + diphosphate + L-histidyl-tRNAHis
show the reaction diagram
-
specifically recognized substrate, derived from tyrosine-accepting tRNA-like domain of brome mosaic virus RNA
-
?
ATP + L-histidine + RNA microhelix
?
show the reaction diagram
ATP + L-histidine + synthetic tRNAHis A-1
AMP + diphosphate + L-histidyl-tRNAHis
show the reaction diagram
-
-
-
?
ATP + L-histidine + synthetic tRNAHis G-1
AMP + diphosphate + L-histidyl-tRNAHis
show the reaction diagram
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidinyl-tRNAHis
show the reaction diagram
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
show the reaction diagram
ATP + L-histidine + tRNAHisCUA
AMP + diphosphate + L-histidyl-tRNAHisCUA
show the reaction diagram
-
-
-
-
?
ATP + L-histidine + tyrosine-accepting tRNA-like domain of brome mosaic virus RNA
AMP + diphosphate + L-histidyl-tyrosine-accepting tRNA-like domain of brome mosaic virus RNA
show the reaction diagram
-
specifically recognized substrate
-
?
ATP + L-histidine + U73tRNAHisGUG
AMP + diphosphate + L-histidyl-U73tRNAHisGUG
show the reaction diagram
-
-
-
-
?
ATP + L-histidine + wild type tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
show the reaction diagram
-
-
-
-
?
ATP + L-histidine + wild-type full length tRNAHis G-1
AMP + diphosphate + L-histidyl-tRNAHis
show the reaction diagram
-
activity is highly dependent upon the recognition of the unique G-1:C73 base pair and the 5'-monophosphate
-
?
dATP + L-histidine + tRNAHis
dAMP + diphosphate + L-histidyl-tRNAHis
show the reaction diagram
-
very poor substrate
-
-
?
additional information
?
-