6.1.1.21: histidine-tRNA ligase

This is an abbreviated version!
For detailed information about histidine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.21

Reaction

ATP
+
L-histidine
+
tRNAHis
=
AMP
+
diphosphate
+
L-histidyl-tRNAHis

Synonyms

Histidyl-tRNA synthetase, Synthetase, histidyl-transfer ribonucleate, Histidyl-transfer ribonucleate synthetase, Histidine translase, HisRS, Jo-1, Jo-1 antigen, Histidine--tRNA ligase, Histidine--tRNA ligase homolog, histidine-tRNA ligase homolog, histidine-tRNA ligase, HRS, histidyl-transfer RNA synthetase, antihistidyl-tRNA synthetase, histidyl tRNA synthetase, HTS1, class II histidyl-tRNA synthetase, HisRS-1, HisRS-2, mitochondrial histidyl tRNA synthetase, HARS1, HARS2, HARS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.21 histidine-tRNA ligase

Application

Application on EC 6.1.1.21 - histidine-tRNA ligase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
alternating catalysis requires a mechanism for coupling events between active sites, presumably through conformational changes propagated between these active sites, a version of HisRS is developed that features the site-specific incorporation of extrinsic environmentally sensitive fluorescent probes, allowing the adenylation reaction to be followed by stopped-flow fluorometry
medicine