6.1.1.20: phenylalanine-tRNA ligase

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For detailed information about phenylalanine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.20

6.1.1.20

aminoacylation

synthetases

aminoacyl-trna

phenylalanylation

thermophilus

thermus

anticodon

aarss

proofreading

phe-trnaphe

noncognate

tyrosyl-trna

misacylated

seryl-trna

threonyl-trna

misaminoacylated

mischarging

trna-phe

aminoacyladenylate

valyl-trna

alphabeta2

biotechnology

Reaction

Synonyms

CML33, ctPheRS, cytoplasmic phenylalanyl-tRNA synthetase, cytosolic phenylalanyl-tRNA synthetase, cytosolic PheRS, EcPheRS, FARS2, FRS, hcPheRS, HSPC173, L-Phenylalanyl-tRNA synthetase, mitochondrial phenylalanyl-tRNA synthetase, mitochondrial PheRS, mitPheRS, More, mtPheRS, p-azido-phenylalanyl-tRNA synthetase, pAzFRS, Phe-RS, Phenylalanine translase, phenylalanine tRNA synthetase, Phenylalanine--tRNA ligase, Phenylalanine-tRNA synthetase, Phenylalanyl transfer ribonucleic acid synthetase, Phenylalanyl-transfer ribonucleate synthetase, Phenylalanyl-transfer RNA ligase, Phenylalanyl-transfer RNA synthetase, Phenylalanyl-tRNA ligase, Phenylalanyl-tRNA synthetase, PheRS, PheRS-alpha, Synthetase, phenylalanyl-transfer ribonucleate

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.20 phenylalanine-tRNA ligase

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Results	in table
4	Activating Compound
102634	AA Sequence
3	Application
1	CAS Registry Number
34	Cloned(Commentary)
61	Cofactor
19	Crystallization (Commentary)
186	Disease/ Diagnostics
4	General Information
1	General Stability
112	IC50 Value
292	Inhibitors
32	kcat/KM [mM/s]
135	Ki Value [mM]
157	KM Value [mM]
33	Localization
33	Metals/Ions
74	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
583	Organism
4	Pathway
123	PDB ID
18	pH Optimum
1	pH Range
1	pH Stability
3	pI Value
1	Posttranslational Modification
71	Protein Variants
35	Purification (Commentary)
11	Reaction
65	Reaction Type
155	Reference
36	Source Tissue
20	Specific Activity [micromol/min/mg]
2	Storage Stability
248	Substrates and Products (Substrate)
69	Subunits
490	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
3	Temperature Range [°C]
10	Temperature Stability [°C]
76	Turnover Number [1/s]

General Information

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General Information on EC 6.1.1.20 - phenylalanine-tRNA ligase

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evolution

Escherichia coli

P08312

architecture of four helix-bundle interface, characteristic of class IIc heterotetrameric aaRSs, is changed, each of the two long helices belonging to CLM transformed into the coil-short helix structural fragments. The N-terminal domain of the alpha-subunit in EcPheRS forms compact triple helix domain

716861

malfunction

2 entries

physiological function

Homo sapiens

O95363

cytosolic phenylalanyl-tRNA synthetase exerts control over the translation accuracy, hydrolyzing misacylated products, while the monomeric mitochondrial enzyme lacks the editing activity

746395