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6.1.1.18: glutamine-tRNA ligase

This is an abbreviated version!
For detailed information about glutamine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.18

Reaction

ATP
+
L-glutamine
 +
tRNAGln
=
AMP
 +
diphosphate
 +
L-glutaminyl-tRNAGln

Synonyms

class I glutaminyl-tRNA synthetase, cytosolic glutaminyl-tRNA synthetase, Gln-RS, Gln4, GlnRS, Glutamine translase, Glutamine--tRNA ligase, Glutamine-tRNA synthetase, glutaminyl tRNA synthetase, Glutaminyl-transfer ribonucleate synthetase, Glutaminyl-transfer RNA synthetase, Glutaminyl-tRNA synthetase, glutaminyltRNA synthetase, glutamyl/glutaminyl-tRNA synthetase, QARS, QRS, Synthetase, glutaminyl-transfer ribonucleate, Vegetative specific protein H4

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.18 glutamine-tRNA ligase

Inhibitors

Inhibitors on EC 6.1.1.18 - glutamine-tRNA ligase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-Methyleneglutamine
-
-
5'-O-[N-(L-glutaminyl)sulfamoyl] adenosine
5,5'-dithiobis(2-nitrobenzoate)
-
-
Br-
-
0.1 M, 50% inhibition
Cl-
-
0.2 M, 50% inhibition
Glu-AMS
-
-
Glutamic acid 4-hydroxamate
-
-
glutaminol adenylate
-
competitive to glutamine
glutaminol adenylate methyl phosphate ester
-
competitive to glutamine
glutaminyl-beta-ketophosphonate-adenosine
-
i.e. Gln-KPA, selective, competitive inhibition of GlnRS, contrast, Gln-KPA inhibits GlnRS by binding competitively but weakly at two distinct sites on the enzyme, the glutamine and the AMP modules of Gln-KPA, connected by the beta-ketophosphonate linker, cannot bind GlnRS simultaneously, and that one Gln-KPA molecule binds the AMP-binding site of GlnRS through its AMP module, whereas another Gln-KPA molecule binds the glutamine-binding site through its glutamine module, mechanism, overview
glutamyl-beta-ketophosphonate-adenosine
-
i.e. Glu-KPA, competitive inhibition, non-cognate, binds weakly at one site on the monomeric enzyme
I-
-
0.06 M, 50% inhibition
L-Glutamic acid
-
competitive inhibition of the wild-type and mutant enzymes
p-hydroxymercuribenzoate
-
-
S-Carbamoylcysteine
-
-
S-Carbamoylserine
-
-
tRNA
-
above 0.6 mg/ml