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6.1.1.17: glutamate-tRNA ligase

This is an abbreviated version!
For detailed information about glutamate-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.17

Reaction

ATP
+
L-glutamate
 +
tRNAGlu
=
AMP
 +
diphosphate
 +
L-glutamyl-tRNAGlu

Synonyms

bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, D-GluRS, discriminating GluRS, EC 2.7.2.13, Ec-GluRS, EPRS, ERS, Ers2, GltX, GluRS, GluRS1, GluRS2, GluRSAt, Glutamate--tRNA ligase, Glutamate-tRNA synthetase, Glutamic acid translase, Glutamic acid tRNA ligase, Glutaminyl-tRNA synthetase, Glutamyl tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, glutamyl-Q tRNAASp synthetase, Glutamyl-transfer ribonucleate synthetase, Glutamyl-transfer ribonucleic acid synthetase, Glutamyl-transfer RNA synthetase, Glutamyl-tRNA synthetase, glutamyl-tRNAsynthetase, GtS, More, P85, surface-exposed glutamyl tRNA synthetase, TM1351, tRNA modifying enzyme, YadB

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.17 glutamate-tRNA ligase

KI Value

KI Value on EC 6.1.1.17 - glutamate-tRNA ligase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.12
(1R,2R)-1-(4-methylsulfonylphenyl)-2-(L-methionylsulfone-amido)-1,3-propanediol
-
pH 7.0, temperature not specified in the publication
0.027
(1R,2R)-1-(4-nitrophenyl)-2-(L-ethionyl-sulfoneamido)-1,3-propanediol
-
pH 7.0, temperature not specified in the publication
0.4
(1R,2R)-1-phenyl-2-(L-methionyl-sulfone-amido)-1,3-propanediol
-
pH 7.0, temperature not specified in the publication
0.37
(1R,2S)-1-(4-nitrophenyl)-2-(L-methionyl-sulfoneamido)-1,3-propanediol
-
pH 7.0, temperature not specified in the publication
2.8
(1S,2R)-1-(4-nitrophenyl)-2-(L-methionyl-sulfoneamido)-1,3-propanediol
-
pH 7.0, temperature not specified in the publication
0.16
(1S,2S)-1-(4-nitrophenyl)-2-(L-methionyl-sulfone-amido)-1,3-propanediol
-
pH 7.0, temperature not specified in the publication
0.015
5'-O-(N'-(L-pyroglutamyl)-sulfamoyl)adenosine
-
-
0.0000028 - 0.00007
5'-O-(N-(L-glutamyl)-sulfamoyl)adenosine
0.0000028
5'-O-[N-(L-glutamyl)sulfamoyl]adenosine
pH and temperature not specified in the publication
0.0007
5'-O-[N-(Lglutamyl)sulfamoyl]adenosine
-
in 100 mM HEPES-KOH, pH 7.2, 30 mM KOH, 12 mM MgCl2, 2 mM dithiothreitol, at 37°C
1.85
chloramphenicol
-
pH 7.0, temperature not specified in the publication
0.027 - 0.101
diphosphate
0.0000028
Glu-AMS
-
pH 7.2, 37°C, versus L-glutamate
2.9
glutaminyl-beta-ketophosphonate-adenosine
-
pH 7.2, 37°C, versus L-glutamate
0.0012 - 0.0039
glutamol-AMP
0.003
glutamyl adenylate
-
37°C
0.63
glutamyl cytidylate
-
37°C
16.7
glutamyl dihydrocytidylate
-
37°C
0.06
glutamyl N6-benzoyladenylate
-
37°C
2.75
glutamyl uridylate
-
37°C
0.018
glutamyl-beta-ketophosphonate-adenosine
-
pH 7.2, 37°C, versus L-glutamate
additional information
additional information
-