6.1.1.17: glutamate-tRNA ligase

This is an abbreviated version!
For detailed information about glutamate-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.17

6.1.1.17

synthetases

aminoacyl-trna

aminoacylation

glnrs

trnagln

ampa

ionotropic

excitatory

anticodon

metabotropic

kainate

glu-trnagln

amidotransferase

n-methyl-d-aspartate

misacylated

glutamatergic

mischarging

trna-dependent

glutaminylation

non-nmda

noncognate

nmdars

transamidation

aspartyl-trna

gatcab

aarss

metrs

trnatyr

isoacceptors

lysyl-trna

non-discriminating

misaminoacylation

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate

ampa-type

glutamate-1-semialdehyde

arginyl-trna

asparaginyl-trna

anticodon-binding

glur2/3

methionyl-trna

trna-binding

drug development

tryptophanyl-trna

Reaction

Synonyms

bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, D-GluRS, discriminating GluRS, EC 2.7.2.13, Ec-GluRS, EPRS, ERS, Ers2, GltX, GluRS, GluRS1, GluRS2, GluRSAt, Glutamate--tRNA ligase, Glutamate-tRNA synthetase, Glutamic acid translase, Glutamic acid tRNA ligase, Glutaminyl-tRNA synthetase, Glutamyl tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, glutamyl-Q tRNAASp synthetase, Glutamyl-transfer ribonucleate synthetase, Glutamyl-transfer ribonucleic acid synthetase, Glutamyl-transfer RNA synthetase, Glutamyl-tRNA synthetase, glutamyl-tRNAsynthetase, GtS, More, P85, surface-exposed glutamyl tRNA synthetase, TM1351, tRNA modifying enzyme, YadB

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.17 glutamate-tRNA ligase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
10	Activating Compound
54930	AA Sequence
2	Application
1	CAS Registry Number
38	Cloned(Commentary)
43	Cofactor
10	Crystallization (Commentary)
143	Disease/ Diagnostics
6	Expression
22	General Information
3	General Stability
2	IC50 Value
50	Inhibitors
14	kcat/KM [mM/s]
28	Ki Value [mM]
72	KM Value [mM]
20	Localization
43	Metals/Ions
33	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
589	Organism
9	Pathway
101	PDB ID
24	pH Optimum
2	pH Range
5	Posttranslational Modification
27	Protein Variants
32	Purification (Commentary)
11	Reaction
46	Reaction Type
121	Reference
20	Source Tissue
17	Specific Activity [micromol/min/mg]
3	Storage Stability
187	Substrates and Products (Substrate)
38	Subunits
140	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
32	Turnover Number [1/s]

General Stability

print visible entries

print all entries

General Stability on EC 6.1.1.17 - glutamate-tRNA ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to General Stability Search

Mycobacterium tuberculosis GluRS is significantly more sensitive than the Escherichia coli form to tryptic and chymotryptic limited proteolysis. Chymotrypsin-sensitive sites are found in the predicted tRNA stem contact domain next to the ATP binding site. Enzyme is fully protected from proteolysis by ATP and glutamol-AMP

Mycobacterium tuberculosis

P9WFV9

703636

no stabilization by various sulfydryl reagents, glycerol and glutamic acid

Vigna radiata var. radiata

214

tRNAGlu in presence of Mg2+ protects against heat inactivation, Mg2+ alone is much less effective

Escherichia coli

212