5.6.2.1: DNA topoisomerase

This is an abbreviated version!
For detailed information about DNA topoisomerase, go to the full flat file.

Reaction

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining =

Synonyms

ATP-independent type I topoisomerase, AtTop1, bcTopo I, bcTopo IIIbeta, bi-subunit topoisomerase I, Bi-subunit topoisomerase IB, Ca-Top1, CrTop1, Dam DNA topoisomerase III, Deoxiribonucleate topoisomerase, Deoxiribonucleic topoisomerase, DNA Top IB, DNA topo I, DNA topoisomerase, DNA topoisomerase 1, DNA topoisomerase I, DNA topoisomerase I alpha, DNA topoisomerase I-B, DNA topoisomerase IB, DNA topoisomerase III, DNA topoisomerase IIIalpha, DNA topoisomerase type I, EC 5.99.1.2, EcTOP, ETOP, HssTopoI, HsTop1, hTop1p, hTopI, hTopo, htopo I, hTopo IIIalpha, hTopoI, human DNA topoisomerase I, human Top1, human topo I, human topoisomerase I, Isomerase, deoxiribonucleate topo-, Late protein H6, LdTop1, LdTOP1L, LdTOP1LS, LdTOP1S, LdTopIIIbeta, MimiTopIB, MsTopA, MtbTopA, mTopoI, MtTOP1, MttopoI, Nicking-closing enzyme, OjTop1, OlTop1, omega-Protein, OpTop1, PfTopI, PfTopoI, Poxviridae topoisomerase IB, Relaxing enzyme, Reverse gyrase, SiRe_1176, SsTop3, Swivelase, top I, Top1, TOP1alpha, TOP1mt, Top1p, TopA, TopI, TopIB, topo 1, Topo I, topo IB, topo V, topoI, Topoisomerase, topoisomerase 1, topoisomerase 1alpha, Topoisomerase I, topoisomerase I homolog, topoisomerase IB, topoisomerase III, topoisomerase IIIalpha, topoisomerase IIIbeta, topoisomerase IV, topoisomerase V, topoisomerase-I, topoIV, TopR1, TpI, Type I DNA topoisomerase, type I topoisomerase, type IA DNA topoisomerase, type IA topoisomerase, type IB topoisomerase, type IB topoisomerase V, Untwisting enzyme, Vaccinia DNA topoisomerase I, variola topoisomerase IB, vTopo, yeast DNA topoisomerase I, yeastTop1, YpTOP, YrdD, YTOP

ECTree

     5 Isomerases

         5.6 Isomerases altering macromolecular conformation

             5.6.2 Enzymes altering nucleic acid conformation

                5.6.2.1 DNA topoisomerase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
28	Activating Compound
82460	AA Sequence
43	Application
1	CAS Registry Number
71	Cloned(Commentary)
4	Cofactor
14	Crystallization (Commentary)
10906	Disease/ Diagnostics
3	Expression
58	General Information
2	General Stability
208	IC50 Value
1185	Inhibitors
1	Ki Value [mM]
5	KM Value [mM]
79	Localization
131	Metals/Ions
82	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
475	Organism
56	pH Optimum
9	pH Range
1	pH Stability
3	pI Value
1	Posttranslational Modification
261	Protein Variants
93	Purification (Commentary)
16	Reaction
2	Reaction Type
360	Reference
355	Source Tissue
16	Specific Activity [micromol/min/mg]
7	Storage Stability
347	Substrates and Products (Substrate)
69	Subunits
427	Synonyms
1	Systematic Name
61	Temperature Optimum [°C]
8	Temperature Range [°C]
17	Temperature Stability [°C]
1	Turnover Number [1/s]

Synonyms

print visible entries

print all entries

Synonyms on EC 5.6.2.1 - DNA topoisomerase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Synonym Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

ATP-independent type I topoisomerase

2 entries

AtTop1

Arabidopsis thaliana

P30181

-

694898

bcTopo I

Bacillus cereus

-

-

662980

bcTopo IIIbeta

2 entries

bi-subunit topoisomerase I

Leishmania donovani

-

-

678081, 682159

Bi-subunit topoisomerase IB

Leishmania sp.

-

-

678080

Ca-Top1

Camptotheca acuminata

-

-

694898

CrTop1

Catharanthus roseus

-

-

694898

Dam DNA topoisomerase III

2 entries

Deoxiribonucleate topoisomerase

-

-

-

-

Deoxiribonucleic topoisomerase

-

-

-

-

DNA Top IB

Homo sapiens

-

-

727204

DNA topo I

Homo sapiens

-

-

714903

DNA topoisomerase

3 entries

DNA topoisomerase 1

2 entries

DNA topoisomerase I

26 entries

DNA topoisomerase I alpha

Arabidopsis thaliana

-

-

747226

DNA topoisomerase I-B

Saccharomyces cerevisiae

-

-

693633

DNA topoisomerase IB

4 entries

DNA topoisomerase III

Escherichia coli

P14294

belongs to the type IA family of DNA topoisomerases

681425

DNA topoisomerase IIIalpha

2 entries

DNA topoisomerase type I

Vaccinia virus

-

-

714188

EC 5.99.1.2

-

-

formerly

-

EcTOP

Escherichia coli

-

-

693679

ETOP

Escherichia coli

P06612

-

694442

HssTopoI

Homo sapiens

-

-

728639

HsTop1

Homo sapiens

P11387

-

694898

hTop1p

2 entries

hTopI

Homo sapiens

-

-

728804

hTopo

Homo sapiens

-

-

682013

htopo I

Homo sapiens

-

-

649801

hTopo IIIalpha

Homo sapiens

-

-

653375

hTopoI

2 entries

human DNA topoisomerase I

Homo sapiens

-

-

694447

human Top1

Homo sapiens

P11387

-

690816, 694898

human topo I

Homo sapiens

-

-

690972

human topoisomerase I

Homo sapiens

P11387

-

694448

Isomerase, deoxiribonucleate topo-

-

-

-

-

Late protein H6

-

-

-

-

LdTop1

Leishmania donovani

-

-

678493

LdTOP1L

Leishmania donovani

-

large subunit

661734

LdTOP1LS

Leishmania donovani

-

-

678081, 682159

LdTOP1S

Leishmania donovani

-

small subunit

661734

LdTopIIIbeta

2 entries

MimiTopIB

Acanthamoeba polyphaga Mimivirus

-

-

681673

MsTopA

Mycolicibacterium smegmatis

-

-

716378

MtbTopA

Mycobacterium tuberculosis

-

-

716378

mTopoI

Mus musculus

Q04750

-

690782

MtTOP1

Mycobacterium tuberculosis

-

-

714607

MttopoI

2 entries

Nicking-closing enzyme

-

-

-

-

OjTop1

Ophiorrhiza japonica

-

-

694898

OlTop1

Ophiorrhiza liukiuensis

-

-

694898

omega-Protein

-

-

-

-

OpTop1

Ophiorrhiza pumila

-

-

694898

PfTopI

Plasmodium falciparum

-

-

678377

PfTopoI

Plasmodium falciparum

-

-

728639

Poxviridae topoisomerase IB

Variola virus

-

-

681975

Relaxing enzyme

-

-

-

-

Reverse gyrase

4 entries

SiRe_1176

2 entries

SsTop3

Saccharolobus solfataricus

-

-

727922

Swivelase

-

-

-

-

top I

Homo sapiens

-

-

692246, 705047

Top1

17 entries

TOP1alpha

2 entries

TOP1mt

-

-

-

-

Top1p

3 entries

TopA

9 entries

TopI

Homo sapiens

-

-

678377, 705827

TopIB

3 entries

topo 1

Homo sapiens

P11387

-

702564, 748358, 748530

Topo I

8 entries

topo IB

Bos taurus

-

-

649613

topo V

Methanopyrus kandleri

-

-

652340, 653669

topoI

7 entries

Topoisomerase

-

-

-

-

topoisomerase 1

3 entries

topoisomerase 1alpha

Arabidopsis thaliana

P30181

-

748912

Topoisomerase I

31 entries

topoisomerase I homolog

Escherichia coli

-

-

727127

topoisomerase IB

5 entries

topoisomerase III

3 entries

topoisomerase IIIalpha

Homo sapiens

-

-

653375

topoisomerase IIIbeta

2 entries

topoisomerase IV

Escherichia coli

-

-

680664

topoisomerase V

Methanopyrus kandleri

-

-

652340, 730059

topoisomerase-I

Homo sapiens

-

-

747474

topoIV

Escherichia coli

-

-

680664

TopR1

2 entries

TpI

-

-

-

-

Type I DNA topoisomerase

4 entries

type I topoisomerase

Bos taurus

-

-

727268

type IA DNA topoisomerase

2 entries

type IA topoisomerase

4 entries

type IB topoisomerase

Vaccinia virus

-

-

661946

type IB topoisomerase V

Methanopyrus kandleri

-

-

653669

Untwisting enzyme

-

-

-

-

Vaccinia DNA topoisomerase I

Vaccinia virus

-

-

678254

variola topoisomerase IB

Variola virus

-

type IB

681975

vTopo

2 entries

yeast DNA topoisomerase I

Saccharomyces cerevisiae

-

-

679462

yeastTop1

Saccharomyces cerevisiae

-

-

679462

YpTOP

Yersinia pestis

Q7CIL8

-

693679

YrdD

Escherichia coli

-

-

727127

YTOP

Yersinia pestis

-

-

662426, 694442

ATP-independent type I topoisomerase

Desulfurococcus amylolyticus

-

-

727807

ATP-independent type I topoisomerase

Desulfurococcus amylolyticus DSM 3822

-

-

-

bcTopo IIIbeta

Bacillus cereus

Q81IH1

-

681990

bcTopo IIIbeta

Bacillus cereus ATCC 14579

Q81IH1

-

-

Dam DNA topoisomerase III

Desulfurococcus amylolyticus

-

-

727807

Dam DNA topoisomerase III

Desulfurococcus amylolyticus DSM 3822

-

-

-

DNA topoisomerase

Homo sapiens

-

-

682013

DNA topoisomerase

Leishmania donovani

-

-

678081

DNA topoisomerase

Vaccinia virus

-

-

682013

DNA topoisomerase 1

Homo sapiens

-

-

702176

DNA topoisomerase 1

Saccharomyces cerevisiae

-

-

680912

DNA topoisomerase I

Bacillus cereus

-

-

662980

DNA topoisomerase I

Bos taurus

P68698

-

693393

DNA topoisomerase I

Camptotheca acuminata

B2DDA7

-

748878

DNA topoisomerase I

Escherichia coli

-

-

682161, 702872, 716834, 748369

DNA topoisomerase I

Escherichia coli

P06612

-

747775

DNA topoisomerase I

Homo sapiens

-

-

677937, 678207, 678377, 679159, 682092, 691221, 691728, 691729, 692660, 692707, 693400, 693401, 702077, 702620, 714330, 728560, 728639, 747263, 747646, 747693, 747698, 748187, 748337, 748369, 749223, 750368, 750702

DNA topoisomerase I

Homo sapiens

P11387

-

747038, 747994, 748397, 748530

DNA topoisomerase I

Leishmania donovani

-

-

678377, 678493

DNA topoisomerase I

Leishmania major

-

-

678377

DNA topoisomerase I

Leishmania sp.

-

-

678080

DNA topoisomerase I

Mammalia

-

-

677299, 678377, 695289

DNA topoisomerase I

Mycobacterium tuberculosis

-

-

702872, 716378, 748396

DNA topoisomerase I

Mycobacterium tuberculosis

A5U8X0

-

726811

DNA topoisomerase I

Mycobacterium tuberculosis H37Ra / ATCC 25177

A5U8X0

-

-

DNA topoisomerase I

Mycolicibacterium smegmatis

-

-

716378

DNA topoisomerase I

Nothapodytes nimmoniana

A0A097ZNA3

-

748878

DNA topoisomerase I

Ophiorrhiza pumila

-

-

748878

DNA topoisomerase I

Plasmodium falciparum

-

-

678377, 728639

DNA topoisomerase I

Saccharomyces cerevisiae

-

-

678082, 679462, 693633, 748397

DNA topoisomerase I

Saccharomyces cerevisiae W303-1A

-

-

-

DNA topoisomerase I

Streptomyces coelicolor

-

-

663213

DNA topoisomerase I

Streptomyces coelicolor M145

-

-

-

DNA topoisomerase I

Trypanosoma brucei

Q581U8

-

678377

DNA topoisomerase I

Trypanosoma congolense

-

-

678377

DNA topoisomerase I

Trypanosoma cruzi

-

-

678377

DNA topoisomerase I

Zea mays

C6KE75

-

706352

DNA topoisomerase IB

Acanthamoeba polyphaga Mimivirus

-

-

681673

DNA topoisomerase IB

Homo sapiens

-

-

705975

DNA topoisomerase IB

Homo sapiens

P11387

-

748358

DNA topoisomerase IB

Vaccinia virus

-

-

661107, 663408

DNA topoisomerase IIIalpha

Caenorhabditis elegans

O61660

-

653381

DNA topoisomerase IIIalpha

Homo sapiens

-

-

651764

hTop1p

Homo sapiens

-

-

694447

hTop1p

Homo sapiens

P11387

-

694448

hTopoI

Homo sapiens

-

-

681403, 682212

hTopoI

Homo sapiens

-

htopoI readily and very efficiently forms double cleavage complexes after the relaxation of negatively supercoiled plasmid DNA both with recombinant enzyme and with purified htopoI. When topo I is isolated from HeLa S3 cells, a considerable fraction migrates to the same gel electrophoretic position as topo I bearing a covalently bound 13-mer oligonucleotide. This may suggest that double cleavage complexes also form under intracellular conditions

677937

LdTopIIIbeta

Leishmania donovani

D0EG00

-

714871

LdTopIIIbeta

Leishmania donovani AG 83

D0EG00

-

-

MttopoI

Mycobacterium tuberculosis

A5U8X0

-

726811

MttopoI

Mycobacterium tuberculosis H37Ra / ATCC 25177

A5U8X0

-

-

Reverse gyrase

-

-

-

-

Reverse gyrase

Saccharolobus solfataricus

-

-

728145

Reverse gyrase

Saccharolobus solfataricus

-

is a DNA topoisomerase, specific to microorganisms living at high temperatures, which comprises a type IA topoisomerase fused to an SF2 helicase-like module and catalyzes ATP hydrolysis-dependent DNA positive supercoiling

727870

Reverse gyrase

Saccharolobus solfataricus P2

-

is a DNA topoisomerase, specific to microorganisms living at high temperatures, which comprises a type IA topoisomerase fused to an SF2 helicase-like module and catalyzes ATP hydrolysis-dependent DNA positive supercoiling

-

SiRe_1176

Sulfolobus islandicus

F0NEW3

locus name

728065

SiRe_1176

Sulfolobus islandicus Rey15A

F0NEW3

locus name

-

Top1

Arabidopsis thaliana

P30181

-

694898

Top1

Camptotheca acuminata

-

-

694898

Top1

Camptotheca acuminata

B2DDA7

-

748878

Top1

Catharanthus roseus

-

-

694898

Top1

Homo sapiens

-

-

681292, 691221, 691619, 692707, 693113, 702176, 702620, 705842, 714760, 715867, 727204, 728098, 728293, 728558, 728560, 747263, 747474, 747693, 748187, 748337, 750702

Top1

Homo sapiens

P11387

-

681288, 693562, 694898, 702665, 747038, 748397

Top1

Homo sapiens

Q969P6

-

690902

Top1

Mus musculus

-

-

691619, 714760

Top1

Mus musculus BALB/c

-

-

-

Top1

Mycobacterium tuberculosis

-

-

748396

Top1

Nothapodytes nimmoniana

A0A097ZNA3

-

748878

Top1

Ophiorrhiza japonica

-

-

694898

Top1

Ophiorrhiza liukiuensis

-

-

694898

Top1

Ophiorrhiza pumila

-

-

694898, 748878

Top1

Saccharomyces cerevisiae

-

-

679462, 693633, 748397

Top1

Saccharomyces cerevisiae W303-1A

-

-

-

Top1

Zea mays

C6KE75

-

706352

TOP1alpha

Arabidopsis thaliana

-

-

747226

TOP1alpha

Arabidopsis thaliana

P30181

-

748912

Top1p

Homo sapiens

P11387

-

748397

Top1p

Saccharomyces cerevisiae

-

-

662311, 680912, 693633, 748397

Top1p

Saccharomyces cerevisiae W303-1A

-

-

-

TopA

Escherichia coli

-

-

727126

TopA

Mycobacterium tuberculosis

P9WG49

-

713968

TopA

Mycobacterium tuberculosis H37Rv

P9WG49

-

-

TopA

Mycolicibacterium smegmatis

-

-

713968

TopA

Saccharolobus solfataricus

-

-

727922

TopA

Streptomyces coelicolor

-

-

663213, 727774

TopA

Streptomyces coelicolor M145

-

-

-

TopA

Thermotoga maritima

P46799

-

728137

TopA

Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589

P46799

-

-

TopIB

Acanthamoeba polyphaga Mimivirus

-

-

681673

TopIB

Deinococcus radiodurans

-

-

716937

TopIB

Homo sapiens

-

-

682092

Topo I

-

-

-

-

Topo I

Escherichia coli

-

-

728393

Topo I

Homo sapiens

-

-

678603, 681674, 690972, 691137, 691264, 691321, 691568, 691608, 691729, 692660, 702885, 703153, 714474, 714643, 714900, 726976, 727417, 747698, 750368

Topo I

Homo sapiens

P11387

-

691006, 747994

Topo I

Leishmania donovani

-

-

681307

Topo I

Mammalia

-

-

677299

Topo I

Mus musculus

-

-

694248

Topo I

Vaccinia virus

-

-

714188

topoI

Escherichia coli

-

-

748369

topoI

Escherichia coli

P06612

-

747775

topoI

Homo sapiens

-

-

693067, 747646, 748369, 749223

topoI

Mus musculus

Q04750

-

690782

topoI

Mycolicibacterium smegmatis

-

-

728406

topoI

Staphylococcus aureus

Q06AK7

-

713959

topoI

Staphylococcus aureus C-66

Q06AK7

-

-

topoisomerase 1

Homo sapiens

-

-

691619

topoisomerase 1

Homo sapiens

P11387

-

702564

topoisomerase 1

Mus musculus

-

-

691619

Topoisomerase I

-

-

-

-

Topoisomerase I

Arabidopsis thaliana

P30181

-

694898

Topoisomerase I

Bos taurus

-

-

727268

Topoisomerase I

Camptotheca acuminata

-

-

694898

Topoisomerase I

Catharanthus roseus

-

-

694898

Topoisomerase I

Escherichia coli

-

-

682161, 693679, 715605, 716786, 726921, 727126, 727704, 728393, 728400

Topoisomerase I

Escherichia coli

P06612

-

694442

Topoisomerase I

Escherichia coli RFM475

-

-

-

Topoisomerase I

Homo sapiens

-

-

677937, 678603, 679159, 681292, 681403, 681408, 681674, 682092, 682169, 682212, 691137, 691221, 691264, 691321, 691568, 691582, 691608, 692246, 692660, 693067, 693113, 693543, 702579, 702598, 702602, 702689, 702885, 703153, 705047, 705827, 705842, 705973, 714448, 714463, 714474, 714643, 714760, 714814, 714900, 714903, 715867, 716007, 716380, 726976, 727170, 727204, 727417, 728098, 728293, 728558, 728579, 728639, 728804

Topoisomerase I

Homo sapiens

-

type IB topoisomerase

690972

Topoisomerase I

Homo sapiens

P11387

-

662238, 681288, 690816, 691006, 693562, 694898, 702665, 705061, 706656

Topoisomerase I

Homo sapiens

Q969P6

-

690902

Topoisomerase I

Leishmania donovani

-

-

678081, 679762, 681307, 682159, 705597

Topoisomerase I

Mus musculus

-

-

694248, 714760

Topoisomerase I

Mus musculus

Q04750

-

690782

Topoisomerase I

Mus musculus BALB/c

-

-

-

Topoisomerase I

Mycobacterium tuberculosis

-

-

714607

Topoisomerase I

Mycobacterium tuberculosis

P9WG49

-

713968

Topoisomerase I

Mycobacterium tuberculosis H37Rv

P9WG49

-

-

Topoisomerase I

Mycolicibacterium smegmatis

-

-

713968, 728406

Topoisomerase I

Ophiorrhiza japonica

-

-

694898

Topoisomerase I

Ophiorrhiza liukiuensis

-

-

694898

Topoisomerase I

Ophiorrhiza pumila

-

-

694898

Topoisomerase I

Plasmodium falciparum

-

-

728639

Topoisomerase I

Rattus norvegicus

-

-

702810

Topoisomerase I

Streptomyces coelicolor

-

-

727774

Topoisomerase I

Thermotoga maritima

P46799

-

728137, 748151

Topoisomerase I

Thermotoga maritima DSM 3109

P46799

-

-

Topoisomerase I

Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589

P46799

-

-

Topoisomerase I

Yersinia pestis

-

-

694442, 715605

Topoisomerase I

Yersinia pestis

Q7CIL8

-

693679

topoisomerase IB

Deinococcus radiodurans

-

-

716937

topoisomerase IB

Homo sapiens

P11387

-

678498

topoisomerase IB

Leishmania sp.

-

-

678080

topoisomerase IB

Trypanosoma brucei

-

-

662799

topoisomerase IB

Vaccinia virus

-

-

661166

topoisomerase III

Escherichia coli

-

-

653935

topoisomerase III

Sulfolobus islandicus

F0NEW3

-

728065

topoisomerase III

Sulfolobus islandicus Rey15A

F0NEW3

-

-

topoisomerase IIIbeta

Bacillus cereus

Q81IH1

subfamily of prokaryotic type IA topoisomerases that are different from the prototypical ecTopo I and ecTopo III-like enzymes

681990

topoisomerase IIIbeta

Bacillus cereus ATCC 14579

Q81IH1

subfamily of prokaryotic type IA topoisomerases that are different from the prototypical ecTopo I and ecTopo III-like enzymes

-

TopR1

Saccharolobus solfataricus

-

-

727870, 728145

TopR1

Saccharolobus solfataricus P2

-

-

-

Type I DNA topoisomerase

-

-

-

-

Type I DNA topoisomerase

Leishmania donovani

-

-

682159

Type I DNA topoisomerase

Mammalia

-

-

695289

Type I DNA topoisomerase

Vaccinia virus

-

-

714188

type IA DNA topoisomerase

Staphylococcus aureus

Q06AK7

-

713959

type IA DNA topoisomerase

Staphylococcus aureus C-66

Q06AK7

-

-

type IA topoisomerase

Escherichia coli

-

-

715605, 726921

type IA topoisomerase

Leishmania donovani

D0EG00

-

714871

type IA topoisomerase

Leishmania donovani AG 83

D0EG00

-

-

type IA topoisomerase

Yersinia pestis

-

-

715605

vTopo

Vaccinia virus

-

-

661107, 678254, 714188

vTopo

Vaccinia virus

-

closely related to the human type I topoisomerase (hTopo)

682013