5.6.2.1: DNA topoisomerase

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For detailed information about DNA topoisomerase, go to the full flat file.

Word Map on EC 5.6.2.1

5.6.2.1

camptothecins

supercoiled

strand

etoposide

poison

topotecan

irinotecan

leukemia

chromatin

cleavable

doxorubicin

single-stranded

fluoroquinolones

quinolone

ovarian

duplex

colorectal

ciprofloxacin

ii-mediated

fork

helicase

schedule

cisplatin

decatenation

antiproliferative

checkpoint

superhelical

novobiocin

intercalation

breakage

dna-damaging

unwind

neutropenia

dose-limiting

s-phase

anthracyclines

cross-resistance

myelosuppression

kinetoplast

taxanes

levofloxacin

nalidixic

mitoxantrone

scleroderma

rejoin

analysis

chk1

medicine

drug development

aphidicolin

etoposide-induced

pharmacology

holliday

diagnostics

norfloxacin

Reaction

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining =

Synonyms

ATP-independent type I topoisomerase, AtTop1, bcTopo I, bcTopo IIIbeta, bi-subunit topoisomerase I, Bi-subunit topoisomerase IB, Ca-Top1, CrTop1, Dam DNA topoisomerase III, Deoxiribonucleate topoisomerase, Deoxiribonucleic topoisomerase, DNA Top IB, DNA topo I, DNA topoisomerase, DNA topoisomerase 1, DNA topoisomerase I, DNA topoisomerase I alpha, DNA topoisomerase I-B, DNA topoisomerase IB, DNA topoisomerase III, DNA topoisomerase IIIalpha, DNA topoisomerase type I, EC 5.99.1.2, EcTOP, ETOP, HssTopoI, HsTop1, hTop1p, hTopI, hTopo, htopo I, hTopo IIIalpha, hTopoI, human DNA topoisomerase I, human Top1, human topo I, human topoisomerase I, Isomerase, deoxiribonucleate topo-, Late protein H6, LdTop1, LdTOP1L, LdTOP1LS, LdTOP1S, LdTopIIIbeta, MimiTopIB, MsTopA, MtbTopA, mTopoI, MtTOP1, MttopoI, Nicking-closing enzyme, OjTop1, OlTop1, omega-Protein, OpTop1, PfTopI, PfTopoI, Poxviridae topoisomerase IB, Relaxing enzyme, Reverse gyrase, SiRe_1176, SsTop3, Swivelase, top I, Top1, TOP1alpha, TOP1mt, Top1p, TopA, TopI, TopIB, topo 1, Topo I, topo IB, topo V, topoI, Topoisomerase, topoisomerase 1, topoisomerase 1alpha, Topoisomerase I, topoisomerase I homolog, topoisomerase IB, topoisomerase III, topoisomerase IIIalpha, topoisomerase IIIbeta, topoisomerase IV, topoisomerase V, topoisomerase-I, topoIV, TopR1, TpI, Type I DNA topoisomerase, type I topoisomerase, type IA DNA topoisomerase, type IA topoisomerase, type IB topoisomerase, type IB topoisomerase V, Untwisting enzyme, Vaccinia DNA topoisomerase I, variola topoisomerase IB, vTopo, yeast DNA topoisomerase I, yeastTop1, YpTOP, YrdD, YTOP

ECTree

5 Isomerases

5.6 Isomerases altering macromolecular conformation

5.6.2 Enzymes altering nucleic acid conformation

5.6.2.1 DNA topoisomerase

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Results	in table
28	Activating Compound
82460	AA Sequence
43	Application
1	CAS Registry Number
71	Cloned(Commentary)
4	Cofactor
14	Crystallization (Commentary)
10906	Disease/ Diagnostics
3	Expression
58	General Information
2	General Stability
208	IC50 Value
1185	Inhibitors
1	Ki Value [mM]
5	KM Value [mM]
79	Localization
131	Metals/Ions
82	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
475	Organism
56	pH Optimum
9	pH Range
1	pH Stability
3	pI Value
1	Posttranslational Modification
261	Protein Variants
93	Purification (Commentary)
16	Reaction
2	Reaction Type
360	Reference
355	Source Tissue
16	Specific Activity [micromol/min/mg]
7	Storage Stability
347	Substrates and Products (Substrate)
69	Subunits
427	Synonyms
1	Systematic Name
61	Temperature Optimum [°C]
8	Temperature Range [°C]
17	Temperature Stability [°C]
1	Turnover Number [1/s]

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