5.6.1.8: myosin ATPase
This is an abbreviated version!
For detailed information about myosin ATPase, go to the full flat file.
Word Map on EC 5.6.1.8
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5.6.1.8
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contractile
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cardiac
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fiber
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cytoskeleton
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tension
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troponin
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ventricular
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f-actin
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myocardial
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artery
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hypertrophy
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myofibrillar
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junction
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microtubule
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cardiomyopathy
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isometric
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cardiomyocytes
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myotubes
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myocytes
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calmodulin
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striated
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soleus
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cytokinesis
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myoblasts
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myogenic
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sarcomere
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myogenesis
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actin-binding
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sliding
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desmin
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dictyostelium
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muscle-specific
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sarcoplasmic
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slide
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stiff
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rhoa
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ventricle
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digitorum
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lateralis
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vastus
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extensor
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unload
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kinesins
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myocarditis
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rock
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twitch
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adhesions
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longus
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microfilaments
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myofibers
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medicine
- 5.6.1.8
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contractile
- cardiac
- fiber
- cytoskeleton
-
tension
- troponin
- ventricular
- f-actin
- myocardial
- artery
- hypertrophy
- myofibrillar
- junction
- microtubule
- cardiomyopathy
-
isometric
- cardiomyocytes
- myotubes
- myocytes
- calmodulin
-
striated
- soleus
-
cytokinesis
- myoblasts
-
myogenic
- sarcomere
-
myogenesis
-
actin-binding
-
sliding
- desmin
- dictyostelium
-
muscle-specific
- sarcoplasmic
-
slide
-
stiff
- rhoa
- ventricle
-
digitorum
- lateralis
-
vastus
- extensor
-
unload
- kinesins
- myocarditis
-
rock
-
twitch
- adhesions
- longus
-
microfilaments
-
myofibers
- medicine
Reaction
Synonyms
actin activated myosin ATPase, actin-stimulated myosin ATPase, actomyosin, actomyosin 1b ATPase, actomyosin ATPase, actomyosin-ATPase, EC 3.6.1.32, EC 3.6.4.1, heavy meromyosin, heavy meromyosin ATPase, HMM, HMM ATPase, matpase, myofibril ATPase, myosin, myosin 2, myosin 2 motor domain, myosin ATPase, myosin II ATPase, myosin II S1, myosin Mg-ATPase, myosin MgATPase, myosin S1 ATPase, myosin-2, myosin-2 ATPase, myosin-ATPase, natural actomyosin, NMIIB, S1-myosin ATPase
ECTree
5.6.1.8 myosin ATPaseAdvanced search results
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results (Activating Compound
Activating Compound on EC 5.6.1.8 - myosin ATPase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
arachidonic acid
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0.0503 mM half-maximal effective concentration, 0.0263 mM half-maximal effective concentration in the presence of actin
Caffeine
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increase in enzyme activity by 4% for non-failing, 11% for idiopathic and 10% ischemic cardiomyopathic hearts
calponin
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1.2fold increase in myosin ATPase activity in the absence of actin
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filamentous actinin
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the enzyme is inhibited by increasing amount of free Mg2+ concentration above 1mM in the presence of filamentous actin, while in the absence of filamentous actinin the inhibitory effect on the enzyme activity is not observed above 1 mM free Mg2+
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leiomodin2
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upon its interaction with the filaments leiomodin2 decreases the actin-activated Mg2+-ATPase activity of skeletal muscle myosin
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MCI-154
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increase in enzyme activity by 11% for non-failing, 19% for idiopathic and 24% ischemic cardiomyopathic hearts
phalloidin F-actin
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up to 6.8fold, fast muscle myosin, up to 2.27fold, slow muscle myosin
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polylysine
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activation may be related to transition from 10 S to 6 S form of myosin ATPase conformation
additional information
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myosin II seems to be activated by a rapid actin-linked mechanism rather than slow myosin light chain phosphorylation
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actin
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actin
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wild-type Dictyostelium actin and L236A mutant activates rabbit skeletal myosin in the presence of tropomyosin-troponin
dioxane
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at acidic pH weak stimulation of cardiac myosin ATPase and strong activation of skeletal myosin ATPase
dioxane
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at acidic pH weak stimulation of cardiac myosin ATPase and strong activation of skeletal myosin ATPase
F-actin
efficiently activates the steady-state ATPase activity of wild-type enzyme about 94fold from a basal value
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F-actin
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myosin Mg-ATPase of molluscan muscles is slightly activated by F-actin under catch state in vitro. At low Ca2+ concentration, Mg-ATPase is activated by F-actin only in the presence of dephosphorylated twitchin, a titin/connectinrelated giant protein, regulates interactions between actin and myosin filaments at low Ca2+ concentrations. When it is dephosphorylated, actin filaments tightly bind to myosin filaments, resulting in the catch state known as the state of high passive tension with very low energy consumption. In the absence of twitchin, F-actin does not bind to myosin filaments
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F-actin
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up to 7.5fold, fast muscle myosin, up to 3.75fold, slow muscle myosin
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myorod
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myorod is expressed exclusively in molluscan catch muscle and localizes on the surface of thick filaments together with twitchin and myosin. Myorod is an alternatively spliced product of themyosin heavy-chain gene that contains the C-terminal rod part of myosin and a unique N-terminal domain. Phosphorylation at the N-terminus of myorod potentiates the actin-activated Mg2+-ATPase activity of mussel myosin, no activation by unphosphorylated myorod. Actomyosin reconstitution from rabbit F-actin and mussel myosin in presence or absence of unphosphorylated or phosphorylated myorod is prepared in two modes, overview
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myorod
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myorod is expressed exclusively in molluscan catch muscle and localizes on the surface of thick filaments together with twitchin and myosin. Myorod is an alternatively spliced product of themyosin heavy-chain gene that contains the C-terminal rod part of myosin and a unique N-terminal domain. Phosphorylation at the N-terminus of myorod potentiates the actin-activated Mg2+-ATPase activity of rabbit myosin, no activation by unphosphorylated myorod. Actomyosin reconstitution from rabbit F-actin and rabbit myosin in presence or absence of unphosphorylated or phosphorylated myorod is prepared in two modes, overview
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