5.5.1.5: Carboxy-cis,cis-muconate cyclase

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For detailed information about Carboxy-cis,cis-muconate cyclase, go to the full flat file.

Word Map on EC 5.5.1.5

5.5.1.5

lactonizing

3-carboxy-cis,cis-muconate

brasiliensis

schenckii

sporotrichosis

sporothrix

niger

humoral

aspergillus

neurospora

bites

gamma-lactone

zoonotic

scratches

globosa

5.5.1.1

regiochemical

cycloisomerase

warm-blooded

stereochemical

eucaryotic

crassa

Reaction

3-carboxy-2,5-dihydro-5-oxofuran-2-acetate

=

3-carboxy-cis,cis-muconate

Synonyms

3-carboxy-5-oxo-2,5-dihydrofuran-2-acetate (decyclizing), 3-Carboxy-cis,cis-muconate lactonizing enzyme, 3-Carboxy-cis-cis-muconate cyclase, 3-Carboxymuconate cyclase, CMLE, Cyclase, carboxy-cis,cis-muconate-

ECTree

5.5 Intramolecular lyases

5.5.1 Intramolecular lyases (only sub-subclass identified to date)

5.5.1.5 Carboxy-cis,cis-muconate cyclase

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Results	in table
51	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
1	General Information
1	General Stability
36	Inhibitors
4	KM Value [mM]
1	Metals/Ions
6	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
26	Organism
2	Pathway
8	PDB ID
2	pH Optimum
2	Posttranslational Modification
2	Purification (Commentary)
2	Reaction
1	Reaction Type
26	Reference
1	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
30	Substrates and Products (Substrate)
3	Subunits
8	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 5.5.1.5 - Carboxy-cis,cis-muconate cyclase

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2-Chloro-4-methylmuconolactone

Aspergillus niger

-

non-competitive

3-carboxy-cis,cis-muconate

Aspergillus niger

-

substrate inhibition at concentration exceeding 0.070 mM

3-chloromuconate

Aspergillus niger

-

competitive

3-Chloromuconolactone

Aspergillus niger

-

non-competitive

3-methylmuconate

Aspergillus niger

-

competitive

adipate

Aspergillus niger

-

-

AsO2-

Aspergillus niger

-

-

AsO43-

Aspergillus niger

-

-

BO33-

Aspergillus niger

-

negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum

Br-

Aspergillus niger

-

-

cis-aconitate

Aspergillus niger

-

-

citraconate

Aspergillus niger

-

-

citrate

Aspergillus niger

-

-

ethoxyformic anhydride

Aspergillus niger

-

irreversible, presence of the competitive inhibitors cis-aconitate, trans-aconitate and cis,cis-muconate conferrs some protection

F-

Aspergillus niger

-

-

fumarate

Aspergillus niger

-

-

glutaconate

Aspergillus niger

-

-

Glutarate

Aspergillus niger

-

-

H2PO2-

Aspergillus niger

-

negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum

I-

Aspergillus niger

-

-

Itaconate

Aspergillus niger

-

-

malate

Aspergillus niger

-

-

Maleate

Aspergillus niger

-

-

malonate

Aspergillus niger

-

-

mesaconate

Aspergillus niger

-

-

NO2-

Aspergillus niger

-

-

NO3-

Aspergillus niger

-

-

oxalate

Aspergillus niger

-

-

phosphate

Aspergillus niger

-

negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum

pimelate

Aspergillus niger

-

-

S2O32-

Aspergillus niger

-

negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum

SO42-

Aspergillus niger

-

-

succinate

Aspergillus niger

-

-

Tartrate

Aspergillus niger

-

-

trans,trans-muconate

Aspergillus niger

-

-

trans-aconitate

Aspergillus niger

-

-

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Release 2023.1 (January 2023)