5.4.99.5: chorismate mutase

This is an abbreviated version!
For detailed information about chorismate mutase, go to the full flat file.

Word Map on EC 5.4.99.5

5.4.99.5

shikimate

sieve

monofunctional

phloem

l-phenylalanine

l-tyrosine

7-phosphate

mutases

t-proteins

3-deoxy-d-arabino-heptulosonate

phenylpyruvate

claisen

arogenate

pericyclic

nonketotic

hyperglycinemia

isochorismate

cyclohexadienyl

hydroxyphenylpyruvate

photorespiratory

preorganization

drug development

3-deoxy-d-arabino-heptulosonate-7-phosphate

meloidogyne

synthesis

agriculture

analysis

Reaction

chorismate

=

prephenate

Synonyms

105-MtCM, 90-MtCM, AmtCM1, AmtCM2, aro7, AroA, AroH, AroQ, AtCM1, AtCM2, AtCM3, Bacillus subtilis chorismate mutase, Bphy_7813, BsAroH, BsCM, BsCM_2, BTH_I1596, chorismate mutase, chorismate mutase 1, chorismate mutase-prephenate dehydrogenase, Chorismate mutase/prephenate dehydratase, CM, CM type 2, CM-1, CM-prephenate dehydratase, CM-TyrAp, CM/PDT, CM/PDT/PDHG, CM0819, CM1, CM2, EcCM, EcCM-R, MI-CM-1, MI-CM-2, MjCM, MTB chorismate mutase, MTB CM, MtbCM, MtCM, Mutase, chorismate, Mycobacterium tuberculosis chorismate mutase, Mycobacterium tuberculosis H37Rv chorismate mutase, NC30, P protein, P-protein, PheA, PpCM1, PpCM2, Rv0948c, Rv1885c, SmCM, Tparo7, TtCM, y2828, YCM

ECTree

5.4 Intramolecular transferases

5.4.99 Transferring other groups

5.4.99.5 chorismate mutase

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Results	in table
54	Activating Compound
34678	AA Sequence
15	Application
1	CAS Registry Number
58	Cloned(Commentary)
1	Cofactor
33	Crystallization (Commentary)
1	Expression
68	General Information
2	General Stability
54	IC50 Value
220	Inhibitors
13	kcat/KM [mM/s]
25	Ki Value [mM]
112	KM Value [mM]
35	Localization
2	Metals/Ions
77	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
400	Organism
12	Pathway
155	PDB ID
34	pH Optimum
4	pH Range
3	pI Value
93	Protein Variants
57	Purification (Commentary)
11	Reaction
20	Reaction Type
167	Reference
7	Renatured (Commentary)
22	Source Tissue
38	Specific Activity [micromol/min/mg]
11	Storage Stability
187	Substrates and Products (Substrate)
63	Subunits
151	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
2	Temperature Range [°C]
30	Temperature Stability [°C]
100	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 5.4.99.5 - chorismate mutase

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0.1

(Z)-3-((5-nitrothiazol-2-yl)imino)indolin-2-one

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.1

(Z)-3-((6-nitrobenzo[d]thiazol-2-yl)imino)indolin-2-one

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.09814

(Z)-3-(hydroxyimino)indolin-2-one

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0305

(Z)-N-(1-acetyl-2-oxoindolin-3-ylidene)hydrazinecarbothioamide

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.025

(Z)-N-(1-acetyl-2-oxoindolin-3-ylidene)hydrazinecarboxamide

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0669

(Z)-N-(2-oxoindolin-3-ylidene)hydrazinecarbothioamide

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0541

(Z)-N-(2-oxoindolin-3-ylidene)hydrazinecarboxamide

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.09656

1-(prop-1-en-2-yl)indoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.00099

1-acetylindoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0227

1-ethylindoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.02158

1-isopropyl-2-methoxy-4-methylbenzene

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.07512

1-isopropylindoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.00196

1-methylindoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0233

1-phenylindoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.041

1-pivaloylindoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0197 - 0.01974

2-chloro-3-(5,6-difluoro-1H-indol-3-yl)quinoxaline

show

0.0239

2-chloro-4-(ethoxycarbonyl)-1-hydroxy-6-methylquinolin-1-ium

Mycobacterium tuberculosis

pH 7.0, 37°C

0.00408

2-isopropyl-5-methylphenyl acetate

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.01363

2-methyl-5-(prop-1-en-2-yl)cyclohexanol

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.00093

3-((5-nitrothiophen-2-yl)methylene)indolin-2-one

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0198

3-(3-methoxyphenyl)-5,6,7,8-tetrahydrobenzo[b]thieno[2,3d]pyrimidin-4[3H]-one

show

0.00101

3-(4-nitrobenzylidene)indolin-2-one

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.01563

3-amino-1-(3-(4-hydroxybut-1-yn-1-yl)phenyl)-1H-benzol[f]chromene-2-carbonitril

show

0.01974

3-chloroquinoxaline

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0214

3-isopropylphenol

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.02677

3-methyl-5-(propan-2-yl)phenol

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0957

5-(2,3-dichlorophenyl)indoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0365

5-(2,5-dimethylphenyl)indoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0557

5-(4-(3-(tert-butyl)phenyl)piperazin-1-yl)indoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0256

5-(4-(furan-2-carbonyl)piperazin-1-yl)indoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0319

5-(4-methylpiperazin-1-yl)indoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0399

5-(piperazin-1-yl)indoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.0288

5-(piperidin-1-yl)indoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.01513

5-naphthyl-7-propyl-3H-pyrazolo-[4,3-d][1,2,3]triazin-4[5h]-one

show

0.01513

5-naphthyl-7-propyl-3H-pyrazolo[4,3-d][1,2,3]triazin-4(5H)-one

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0371

5-phenylindoline-2,3-dione

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.00106

carvacrol

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0148

ethyl 4-(2-(4-hydroxybut-1-yn-1-yl)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Mycobacterium tuberculosis

pH 7.0, 37°C

0.02858

eugenol

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.00101

indoline-2,3-dione

Mycobacterium tuberculosis

pH 7.0, 37°C

0.00108

isatin

Mycobacterium tuberculosis

-

pH and temperature not specified in the publication

0.02638

menthol

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.01563

N-[(3-(2-amino-3-cyano-2H-benzo[h]chromen-4-y))phenyl]methylidyne]-2-hydroxyethanaminium

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0231

o-Cresol

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0116

p-cymene

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.007 - 18

Saccharomyces cerevisiae chorismate mutase inhibitors

show

-

0.0284

Thymol

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0248

Vanillin

Mycobacterium tuberculosis

pH and temperature not specified in the publication

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Release 2023.1 (January 2023)