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5.4.99.2: methylmalonyl-CoA mutase

This is an abbreviated version!
For detailed information about methylmalonyl-CoA mutase, go to the full flat file.

Word Map on EC 5.4.99.2

Reaction

(R)-methylmalonyl-CoA
=
succinyl-CoA

Synonyms

(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase, (S)-Methylmalonyl-CoA mutase, cobalamin-dependent methylmalonyl-CoA mutase, hMCM, L-methylmalonyl-co-enzyme-A mutase, L-methylmalonyl-CoA mutase, MCB-beta, MCM, MCM-alpha, MCM-beta, mcmB, Methylmalonyl CoA mutase, Methylmalonyl coenzyme A carbonylmutase, Methylmalonyl coenzyme A mutase, methylmalonyl-CoA mutase, Methylmalonyl-CoA-carbonyl mutase, mitochondrial methylmalonyl-CoA mutase, mmcm-1, Msed_0638, Msed_2055, MuT, Mutase, methylmalonyl coenzyme A, Sbm, sleeping beauty mutase

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.2 methylmalonyl-CoA mutase

Specific Activity

Specific Activity on EC 5.4.99.2 - methylmalonyl-CoA mutase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000052
-
baby hamster kidney cells grown in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum, lacking hydroxycobalamin, 37°C, pH 7.4
0.0002
-
cell extracts preincubated with 5 microM adenosylcobalamin, 37°C, pH 7.4
0.0021
O74009; O58013
purified recombinant His-tagged enzyme, in presence of cofactor 5'-deoxyadenosylcobalamin, pH 7.5, 37°C
0.06
crude homogenate, at 40°C
1.33
-
-
10.85
-
after UNO Q-1 purification
2.2
A4YEG1; A4YIE3
75°C, pH not specified in the publication
21
after 350fold purification, at 40°C
67.4
-
-
additional information