5.4.3.8: glutamate-1-semialdehyde 2,1-aminomutase
This is an abbreviated version!
For detailed information about glutamate-1-semialdehyde 2,1-aminomutase, go to the full flat file.
Word Map on EC 5.4.3.8
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5.4.3.8
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chlorophyll
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5-aminolevulinic
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tetrapyrrole
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glutamyl-trna
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delta-aminolevulinic
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synechococcus
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gabaculine
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hema
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4,5-diaminovalerate
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trnaglu
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4,5-dioxovalerate
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aldimine
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glutr
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five-carbon
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glutamyl-trnaglu
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trna-dependent
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3-amino-2,3-dihydrobenzoic
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chelatase
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mg-chelatase
- 5.4.3.8
- chlorophyll
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5-aminolevulinic
- tetrapyrrole
- glutamyl-trna
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delta-aminolevulinic
- synechococcus
- gabaculine
- hema
- 4,5-diaminovalerate
- trnaglu
- 4,5-dioxovalerate
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aldimine
- glutr
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five-carbon
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glutamyl-trnaglu
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trna-dependent
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3-amino-2,3-dihydrobenzoic
- chelatase
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mg-chelatase
Reaction
Synonyms
Aminotransferase, glutamate semialdehyde, AtGSA1, EC 2.7.2.13, Glutamate 1-semialdehyde aminotransferase, glutamate-1-semialdehyde amino-transferase, glutamate-1-semialdehyde aminomutase, Glutamate-1-semialdehyde aminotransferase, glutamate-1-semialdehyde-2,1-aminomutase, glutamate-1-semialdehyde-aminomutase, GSA, GSA aminotransferase, GSA-AT, GSA1, GSAM, GSAT, HemL, PA4088, protein PA4088
ECTree
5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 5.4.3.8 - glutamate-1-semialdehyde 2,1-aminomutase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-4-Amino-5-oxopentanoate
5-Amino-4-oxopentanoate
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-
-
?
(S)-4-Amino-5-oxopentanoate
5-Amino-4-oxopentanoate
-
-
?
(S)-4-Amino-5-oxopentanoate
5-Amino-4-oxopentanoate
-
-
?
(S)-4-Amino-5-oxopentanoate
5-Amino-4-oxopentanoate
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anomalous enantiomeric reaction with the (R)enantiomer
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?
(S)-4-amino-5-oxopentanoate
5-aminolevulinate
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involved in chlorophyll biosynthesis
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r
(S)-4-amino-5-oxopentanoate
5-aminolevulinate
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involved in conversion of glutamate to 5-aminolevulinate
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r
(S)-4-Amino-5-oxopentanoate
?
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formation of 5-aminolevulinic acid, which is the first committed precursor of chlorophyll biosynthesis in the chloroplast
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-
?
(S)-4-Amino-5-oxopentanoate
?
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4,5-dioxovalerate and 4,5-diaminovalerate are reaction intermediates
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-
?
(S)-4-Amino-5-oxopentanoate
?
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key enzyme in plant tetrapyrrole synthesis
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-
?
(S)-4-Amino-5-oxopentanoate
?
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4,5-diaminovalerate may be an intermediate in the synthesis of 5-amino-4-oxopentanoate
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-
?
(S)-4-Amino-5-oxopentanoate
?
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enzyme catalyzes the last step in the conversion of Glu to 5-amino-4-oxopentanoate
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-
?
(S)-4-Amino-5-oxopentanoate
?
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the enzyme may catalyze a part reaction in the conversion of L-Glu to 5-amino-4-oxopentanoate in greening plastids
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-
?
(S)-4-Amino-5-oxopentanoate
?
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key enzyme in the synthetic pathway leading to chlorophyll
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-
?
(S)-4-Amino-5-oxopentanoate
?
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enzyme catalyzes the last step in the conversion of Glu to 5-amino-4-oxopentanoate
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-
?
(S)-4-Amino-5-oxopentanoate
?
enzyme catalyzes the last step in the conversion of Glu to 5-amino-4-oxopentanoate
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-
?
(S)-4-Amino-5-oxopentanoate
?
enzyme catalyzes the last step in the conversion of Glu to 5-amino-4-oxopentanoate
-
-
?
(S)-4-Amino-5-oxopentanoate
?
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one of three enzymes in formation of 5-aminolevulinic acid from Glu via the five-carbon pathway
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-
?
4,5-Diaminovalerate
?
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is a substrate for the pyridoxal 5'-phosphate form of the enzyme
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-
?
4,5-Diaminovalerate
?
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is a substrate for the pyridoxal 5'-phosphate form of the enzyme
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-
?
4,5-Diaminovalerate
?
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is a substrate for the pyridoxal 5'-phosphate form of the enzyme
-
-
?
4,5-Dioxovalerate
5-Amino-4-oxopentanoate
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is a substrate for the pyridoxamine form of the enzyme
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?
4,5-Dioxovalerate
5-Amino-4-oxopentanoate
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is a substrate for the pyridoxamine form of the enzyme
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?
4,5-Dioxovalerate
5-Amino-4-oxopentanoate
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is a substrate for the pyridoxamine form of the enzyme
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?
glutamate-1-semialdehyde
5-amino-levulinate
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the enzyme is involved in biosynthesis of the tetrapyrrole precursor, delta-aminolevulinic acid, from glutamate by the tRNA-dependent five-carbon pathway
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-
?
glutamate-1-semialdehyde
5-amino-levulinate
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the enzyme is involved in biosynthesis of the tetrapyrrole precursor, delta-aminolevulinic acid, from glutamate by the tRNA-dependent five-carbon pathway
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-
?
L-glutamate 1-semialdehyde
5-aminolevulinate
Corynebacterium glutamicum ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025
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-
-
?
L-glutamate 1-semialdehyde
5-aminolevulinate
Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1
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-
-
?
additional information
?
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enzyme GSAM catalyzes the transamination of GSA substrate to form 5-aminolevulinate by an unusual intramolecular exchange of amino and oxo groups via the intermediate 4,5-diaminovalerate (DAVA). The reaction starts with imine formation between pyridoxamine 5'-phosphate and the aldehyde of GSA. During the first half of the reaction pyridoxamine 5'-phosphate is converted to pyridoxal 5'-phosphate, while pyridoxamine 5'-phosphate is regenerated in the second half of the reaction upon 5-aminolevulinate formation
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-
?
additional information
?
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enzyme GSAM catalyzes the transamination of GSA substrate to form 5-aminolevulinate by an unusual intramolecular exchange of amino and oxo groups via the intermediate 4,5-diaminovalerate (DAVA). The reaction starts with imine formation between pyridoxamine 5'-phosphate and the aldehyde of GSA. During the first half of the reaction pyridoxamine 5'-phosphate is converted to pyridoxal 5'-phosphate, while pyridoxamine 5'-phosphate is regenerated in the second half of the reaction upon 5-aminolevulinate formation
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-
?
additional information
?
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complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis suggests direct metabolic channeling between both enzymes to protect the reactive aldehyde species glutamate-1-semialdehyde
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-
?
