5.4.3.8: glutamate-1-semialdehyde 2,1-aminomutase

This is an abbreviated version!
For detailed information about glutamate-1-semialdehyde 2,1-aminomutase, go to the full flat file.

Reaction

Synonyms

Aminotransferase, glutamate semialdehyde, AtGSA1, EC 2.7.2.13, Glutamate 1-semialdehyde aminotransferase, glutamate-1-semialdehyde amino-transferase, glutamate-1-semialdehyde aminomutase, Glutamate-1-semialdehyde aminotransferase, glutamate-1-semialdehyde-2,1-aminomutase, glutamate-1-semialdehyde-aminomutase, GSA, GSA aminotransferase, GSA-AT, GSA1, GSAM, GSAT, HemL, PA4088, protein PA4088

ECTree

     5 Isomerases

         5.4 Intramolecular transferases

             5.4.3 Transferring amino groups

                5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase

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Results	in table
3	Activating Compound
32180	AA Sequence
1	CAS Registry Number
17	Cloned(Commentary)
25	Cofactor
8	Crystallization (Commentary)
2	Expression
8	General Information
2	IC50 Value
23	Inhibitors
8	KM Value [mM]
5	Localization
2	Metals/Ions
17	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
74	Organism
7	Pathway
50	PDB ID
3	pH Optimum
2	pH Range
8	Protein Variants
16	Purification (Commentary)
8	Reaction
2	Reaction Type
47	Reference
7	Source Tissue
8	Specific Activity [micromol/min/mg]
68	Substrates and Products (Substrate)
19	Subunits
39	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 5.4.3.8 - glutamate-1-semialdehyde 2,1-aminomutase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

4,5-Dioxovalerate

Synechococcus sp.

-

competitive inhibition of pyridoxamine-phosphate form of the enzyme and mixed-type inhibition of the pyridoxal-phosphate form of the enzyme

3441

4-Amino-5-fluoro-pentanoic acid

Synechococcus sp.

-

-

3429

4-Amino-5-hexenoic acid

Pisum sativum

-

-

3431

4-Amino-5-hexynoic acid

Pisum sativum

-

-

3431

Aminooxyacetate

2 entries

cycloserine

Hordeum vulgare

-

20 mM, 43% inhibition

3419

D-penicillamine

Hordeum vulgare

-

20 mM, 9% inhibition

3419

gabaculine

8 entries

glyoxylate

Hordeum vulgare

-

20 mM, 27% inhibition

3419

p-chloromercuribenzoate

Hordeum vulgare

-

0.1 mM, 45% inhibition

3419

pyridoxal 5'-phosphate

2 entries

additional information

3 entries

-

Aminooxyacetate

Chlamydomonas reinhardtii

-

-

3436

Aminooxyacetate

Hordeum vulgare

-

20 mM, 57% inhibition

3419

gabaculine

Chlamydomonas reinhardtii

-

-

3436

gabaculine

Hordeum vulgare

-

0.005 mM, 83% inhibition. Irreversible inhibition which requires the presence of either glutamate-1-semialdehyde or 5-amino-4-oxopentanoate

3423

gabaculine

Hordeum vulgare

-

complete inactivation by gabaculine when the enzyme is exposed to 5-amino-4-oxopentanoate, levulinate or 4,5-dioxovalerate in absence of glutamate 1-semialdehyde

3425

gabaculine

Saccharolobus solfataricus

-

-

721440

gabaculine

Synechococcus sp.

-

0.0005 mM, 50% inhibition. The inhibition is reversible up to 1 h after its addition, if the gabaculine is removed by gel filtration, before the enzyme is incubated by gel filtration, before the enzyme is incubated with substrate. Irreversible inhibition is obtained by preincubation of the enzyme at 30°C either for several hours with gabaculine alone or for a few min with both gabaculine and glutamate-1-semialdehyde

3426

gabaculine

Synechococcus sp.

-

-

3429

gabaculine

Synechococcus sp.

-

wild-type enzyme is inhibited, gabaculine-resistant mutant enzyme is not inhibited

3430

gabaculine

Synechococcus sp.

P24630

potent inhibitor

703619

pyridoxal 5'-phosphate

Hordeum vulgare

-

5 mM, 47% inhibition

3419

pyridoxal 5'-phosphate

Synechococcus sp.

-

-

3429

additional information

Chlorella vulgaris

-

5 mM EDTA has no effect on activity

3434

-

additional information

Hordeum vulgare

-

no inhibition by 3-hydroxyglutamate

3419

-

additional information

Synechococcus sp.

-

5 mM EDTA has no effect on activity

3434

-