5.4.3.5: D-ornithine 4,5-aminomutase
This is an abbreviated version!
For detailed information about D-ornithine 4,5-aminomutase, go to the full flat file.
Word Map on EC 5.4.3.5
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5.4.3.5
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pyridoxal
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sticklandii
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adocbl
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homolysis
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5'-phosphate
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plp-dependent
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5,6-aminomutase
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aldimine
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rossmann
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radical-based
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stopped-flow
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5\'-deoxyadenosyl
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paramagnetic
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1,2-amino
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deprotonated
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d-lysine
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cobalamin-binding
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rupture
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ribose
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imine
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interconverting
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5\'-deoxyadenosylcobalamin
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multistep
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adocbl-dependent
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isomerization
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pyridoxal-5'-phosphate
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pyridine
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uv-visible
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refolding
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synergy
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b12-dependent
- 5.4.3.5
- pyridoxal
- sticklandii
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adocbl
-
homolysis
- 5'-phosphate
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plp-dependent
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5,6-aminomutase
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aldimine
-
rossmann
-
radical-based
-
stopped-flow
-
5\'-deoxyadenosyl
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paramagnetic
-
1,2-amino
-
deprotonated
- d-lysine
-
cobalamin-binding
-
rupture
- ribose
- imine
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interconverting
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5\'-deoxyadenosylcobalamin
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multistep
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adocbl-dependent
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isomerization
- pyridoxal-5'-phosphate
- pyridine
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uv-visible
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refolding
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synergy
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b12-dependent
Reaction
Synonyms
4,5-OAM, adenosylcobalamin-dependent ornithine 4,5-aminomutase, Aminomutase, D-ornithine 4,5-, D-ornithine aminomutase, OAM, oraE, oraS, ornithine 4,5-aminomutase, ornithine aminomutase
ECTree
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Subunits
Subunits on EC 5.4.3.5 - D-ornithine 4,5-aminomutase
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heterotetramer
tetramer
additional information
heterotetramer
alpha2beta2, OraS, OraE, 2 * 12800 + 2 * 82900
heterotetramer
alpha2beta2, 2 * 12800, alpha-subunit, + 2 * 82900, beta-subunit, SDS-PAGE
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alpha2beta2, 2 * 12800 + 2 * 82900, deduced from nucleotide sequence
tetramer
2 * 12800, subunit OraS + 2 * 82900, subunit OraE, alpha2beta2
tetramer
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2 * 12800, subunit OraS + 2 * 90000, subunit OraE, alpha2beta2
tetramer
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2 * 12800, subunit OraS + 2 * 82900, subunit OraE, alpha2beta2
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protein KamDE comprised of the 30000 and 51000 Da subunits of the E1 component of D-alpha-lysine aminomutase is catalytically active in absence of the third 12800 kDa subunit, but ATP no longer has a regulatory effect on it. The S subunit of D-ornithine aminomutase, OraS, is capable of forming a complex with KamDE and restores the enzymes ATP-dependent allosteric regulation
additional information
enzyme OAM is an alpha2beta2 heterodimer comprised of two strongly associating subunits, OraE (82.9 kDa) and OraS (12.8 kDa).7 Each OraE subunit comprises a triosephosphate isomerase (TIM) barrel domain and a Rossmann-like domain. A domain swap occurs in the heterodimer, whereby the Rossmann-like domain of one OraE subunit associates with the TIM barrel domain of a second OraE subunit and vice versa, such that two identical active sites are formed
additional information
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enzyme OAM is an alpha2beta2 heterodimer comprised of two strongly associating subunits, OraE (82.9 kDa) and OraS (12.8 kDa).7 Each OraE subunit comprises a triosephosphate isomerase (TIM) barrel domain and a Rossmann-like domain. A domain swap occurs in the heterodimer, whereby the Rossmann-like domain of one OraE subunit associates with the TIM barrel domain of a second OraE subunit and vice versa, such that two identical active sites are formed