5.4.3.5: D-ornithine 4,5-aminomutase
This is an abbreviated version!
For detailed information about D-ornithine 4,5-aminomutase, go to the full flat file.
Word Map on EC 5.4.3.5
-
5.4.3.5
-
pyridoxal
-
sticklandii
-
adocbl
-
homolysis
-
5'-phosphate
-
plp-dependent
-
5,6-aminomutase
-
aldimine
-
rossmann
-
radical-based
-
stopped-flow
-
5\'-deoxyadenosyl
-
paramagnetic
-
1,2-amino
-
deprotonated
-
d-lysine
-
cobalamin-binding
-
rupture
-
ribose
-
imine
-
interconverting
-
5\'-deoxyadenosylcobalamin
-
multistep
-
adocbl-dependent
-
isomerization
-
pyridoxal-5'-phosphate
-
pyridine
-
uv-visible
-
refolding
-
synergy
-
b12-dependent
- 5.4.3.5
- pyridoxal
- sticklandii
-
adocbl
-
homolysis
- 5'-phosphate
-
plp-dependent
-
5,6-aminomutase
-
aldimine
-
rossmann
-
radical-based
-
stopped-flow
-
5\'-deoxyadenosyl
-
paramagnetic
-
1,2-amino
-
deprotonated
- d-lysine
-
cobalamin-binding
-
rupture
- ribose
- imine
-
interconverting
-
5\'-deoxyadenosylcobalamin
-
multistep
-
adocbl-dependent
-
isomerization
- pyridoxal-5'-phosphate
- pyridine
-
uv-visible
-
refolding
-
synergy
-
b12-dependent
Reaction
Synonyms
4,5-OAM, adenosylcobalamin-dependent ornithine 4,5-aminomutase, Aminomutase, D-ornithine 4,5-, D-ornithine aminomutase, OAM, oraE, oraS, ornithine 4,5-aminomutase, ornithine aminomutase
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Reference
Reference on EC 5.4.3.5 - D-ornithine 4,5-aminomutase
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Somack, R.; Costilow, R.N.
Purification and properties of a pyridoxal phosphate and coenzyme B12 dependent D-alpha-ornithine 5,4-aminomutase
Biochemistry
12
2597-2604
1973
Acetoanaerobium sticklandii
Chen, H.P.; Wu, S.H.; Lin, Y.L.; Chen, C.M.; Tsay, S.S.
Cloning, sequencing, heterologous expression, purification, and characterization of adenosylcobalamin-dependent D-ornithine aminomutase from Clostridium sticklandii
J. Biol. Chem.
276
44744-44750
2001
Acetoanaerobium sticklandii
Chen, H.P.; Hsui, F.C.; Lin, L.Y.; Ren, C.T.; Wu, S.H.
Coexpression, purification and characterization of the E and S subunits of coenzyme B(12) and B(6) dependent Clostridium sticklandii D-ornithine aminomutase in Escherichia coli
Eur. J. Biochem.
271
4293-4297
2004
Acetoanaerobium sticklandii
Tseng, C.H.; Yang, C.H.; Lin, H.J.; Wu, C.; Chen, H.P.
The S subunit of D-ornithine aminomutase from Clostridium sticklandii is responsible for the allosteric regulation in D-alpha-lysine aminomutase
FEMS Microbiol. Lett.
274
148-153
2007
Acetoanaerobium sticklandii
Wolthers, K.R.; Rigby, S.E.; Scrutton, N.S.
Mechanism of radical-based catalysis in the reaction catalyzed by adenosylcobalamin-dependent ornithine 4,5-aminomutase
J. Biol. Chem.
283
34615-34625
2008
Acetoanaerobium sticklandii
Fonknechten, N.; Perret, A.; Perchat, N.; Tricot, S.; Lechaplais, C.; Vallenet, D.; Vergne, C.; Zaparucha, A.; Le Paslier, D.; Weissenbach, J.; Salanoubat, M.
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine
J. Bacteriol.
191
3162-3167
2009
Clostridioides difficile, Acetoanaerobium sticklandii, Cutibacterium acnes, Alkaliphilus metalliredigens, Fervidobacterium nodosum Rt17-B1, Alkaliphilus oremlandii, Petrotoga mobilis, Thermoanaerobacter pseudethanolicus, Natranaerobius thermophilus, Thermosipho melanesiensis, Natranaerobius thermophilus JW/NM-WN-LF, Clostridioides difficile 630, Thermosipho melanesiensis BI429, Petrotoga mobilis SJ95, Thermoanaerobacter pseudethanolicus MB4, Cutibacterium acnes KPA171202, Alkaliphilus oremlandii OhlLAs
Wolthers, K.R.; Levy, C.; Scrutton, N.S.; Leys, D.
Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase
J. Biol. Chem.
285
13942-13950
2010
Acetoanaerobium sticklandii (E3PY95), Acetoanaerobium sticklandii (E3PY96), Acetoanaerobium sticklandii
Makins, C.; Pickering, A.V.; Mariani, C.; Wolthers, K.R.
Mutagenesis of a conserved glutamate reveals the contribution of electrostatic energy to adenosylcobalamin co-C bond homolysis in ornithine 4,5-aminomutase and methylmalonyl-CoA mutase
Biochemistry
52
878-888
2013
Acetoanaerobium sticklandii (E3PY95), Acetoanaerobium sticklandii (E3PY96), Acetoanaerobium sticklandii, Acetoanaerobium sticklandii DSM 519 (E3PY95), Acetoanaerobium sticklandii DSM 519 (E3PY96)
Makins, C.; Miros, F.N.; Scrutton, N.S.; Wolthers, K.R.
Role of histidine 225 in adenosylcobalamin-dependent ornithine 4,5-aminomutase
Bioorg. Chem.
40
39-47
2012
Acetoanaerobium sticklandii (E3PY95), Acetoanaerobium sticklandii (E3PY96), Acetoanaerobium sticklandii DSM 519 (E3PY95), Acetoanaerobium sticklandii DSM 519 (E3PY96)
Maity, A.N.; Chen, Y.H.; Ke, S.C.
Large-scale domain motions and pyridoxal-5-phosphate assisted radical catalysis in coenzyme B12-dependent aminomutases
Int. J. Mol. Sci.
15
3064-3087
2014
Acetoanaerobium sticklandii
Pang, J.; Li, X.; Morokuma, K.; Scrutton, N.S.; Sutcliffe, M.J.
Large-scale domain conformational change is coupled to the activation of the Co-C bond in the B12-dependent enzyme ornithine 4,5-aminomutase: a computational study
J. Am. Chem. Soc.
134
2367-2377
2012
Acetoanaerobium sticklandii
Makins, C.; Whitelaw, D.A.; Mu, C.; Walsby, C.J.; Wolthers, K.R.
Isotope effects for deuterium transfer and mutagenesis of Tyr187 provide insight into controlled radical chemistry in adenosylcobalamin-dependent ornithine 4,5-aminomutase
Biochemistry
53
5432-5443
2014
Acetoanaerobium sticklandii (E3PY95 AND E3PY96), Acetoanaerobium sticklandii
Makins, C.; Whitelaw, D.A.; McGregor, M.; Petit, A.; Mothersole, R.G.; Prosser, K.E.; Wolthers, K.R.
Optimal electrostatic interactions between substrate and protein are essential for radical chemistry in ornithine 4,5-aminomutase
Biochim. Biophys. Acta
1865
1077-1084
2017
Acetoanaerobium sticklandii (E3PY95 AND E3PY96), Acetoanaerobium sticklandii, Acetoanaerobium sticklandii DSM 519 (E3PY95 AND E3PY96)
Pang, J.; Scrutton, N.S.; Sutcliffe, M.J.
Quantum mechanics/molecular mechanics studies on the mechanism of action of cofactor pyridoxal 5-phosphate in ornithine 4,5-aminomutase
Chemistry
20
11390-11401
2014
Acetoanaerobium sticklandii (E3PY95 AND E3PY96)
Menon, B.R.; Menon, N.; Fisher, K.; Rigby, S.E.; Leys, D.; Scrutton, N.S.
Glutamate 338 is an electrostatic facilitator of C-Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase
FEBS J.
282
1242-1255
2015
Acetoanaerobium sticklandii (E3PY95 AND E3PY96)
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